Human antibodies in Mexico and Brazil neutralizing tick-borne
flaviviruses

J 2024

Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses

RINCON, Tomas Cervantes; Tania KAPOOR; Jennifer R KEEFFE; Luca SIMONELLI; Hans -Heinrich HOFFMANN et al.

Základní údaje

Originální název

Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses

Autoři

Vydání

Cell Reports, CAMBRIDGE, Cell Press, 2024, 2211-1247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.900

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00138780

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

antibodies; flaviviruses; tick diseases

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 2. 2025 13:05, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito -borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.

Citovat

RINCON, Tomas Cervantes; Tania KAPOOR; Jennifer R KEEFFE; Luca SIMONELLI; Hans -Heinrich HOFFMANN; Marianna AGUDELO; Andrea JURADO; Avery PEACE; Yu E LEE; Anna GAZUMYAN; Francesca GUIDETTI; Jasmine CANTERGIANI; Benedetta CENA; Filippo BIANCHINI; Elia TAMAGNINI; Simone G MORO; Pavel SVOBODA; Federico COSTA; Mitermayer G REIS; Albert I KO; Brian A FALLON; Santiago AVILA-RIOS; Gustavo REYES-TERAN; Charles M RICE; Michel C NUSSENZWEIG; Pamela J BJORKMAN; Daniel RŮŽEK; Luca VARANI; Margaret R MACDONALD a Davide F ROBBIANI. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cell Reports. CAMBRIDGE: Cell Press, 2024, roč. 43, č. 6, s. 1-18. ISSN 2211-1247. Dostupné z: https://doi.org/10.1016/j.celrep.2024.114298.

@article{2474891,
   author = {Rincon, Tomas Cervantes and Kapoor, Tania and Keeffe, Jennifer R and Simonelli, Luca and Hoffmann, Hans andHeinrich and Agudelo, Marianna and Jurado, Andrea and Peace, Avery and Lee, Yu E and Gazumyan, Anna and Guidetti, Francesca and Cantergiani, Jasmine and Cena, Benedetta and Bianchini, Filippo and Tamagnini, Elia and Moro, Simone G and Svoboda, Pavel and Costa, Federico and Reis, Mitermayer G and Ko, Albert I and Fallon, Brian A and AvilaandRios, Santiago and ReyesandTeran, Gustavo and Rice, Charles M and Nussenzweig, Michel C and Bjorkman, Pamela J and Růžek, Daniel and Varani, Luca and Macdonald, Margaret R and Robbiani, Davide F},
   article_location = {CAMBRIDGE},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.celrep.2024.114298},
   keywords = {antibodies; flaviviruses; tick diseases},
   language = {eng},
   issn = {2211-1247},
   journal = {Cell Reports},
   title = {Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses},
   url = {https://www.sciencedirect.com/science/article/pii/S2211124724006260},
   volume = {43},
   year = {2024}
}

TY  - JOUR
ID  - 2474891
AU  - Rincon, Tomas Cervantes - Kapoor, Tania - Keeffe, Jennifer R - Simonelli, Luca - Hoffmann, Hans -Heinrich - Agudelo, Marianna - Jurado, Andrea - Peace, Avery - Lee, Yu E - Gazumyan, Anna - Guidetti, Francesca - Cantergiani, Jasmine - Cena, Benedetta - Bianchini, Filippo - Tamagnini, Elia - Moro, Simone G - Svoboda, Pavel - Costa, Federico - Reis, Mitermayer G - Ko, Albert I - Fallon, Brian A - Avila-Rios, Santiago - Reyes-Teran, Gustavo - Rice, Charles M - Nussenzweig, Michel C - Bjorkman, Pamela J - Růžek, Daniel - Varani, Luca - Macdonald, Margaret R - Robbiani, Davide F
PY  - 2024
TI  - Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
JF  - Cell Reports
VL  - 43
IS  - 6
SP  - 1-18
EP  - 1-18
PB  - Cell Press
SN  - 22111247
KW  - antibodies
KW  - flaviviruses
KW  - tick diseases
UR  - https://www.sciencedirect.com/science/article/pii/S2211124724006260
N2  - Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito -borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
ER  -

RINCON, Tomas Cervantes; Tania KAPOOR; Jennifer R KEEFFE; Luca SIMONELLI; Hans -Heinrich HOFFMANN; Marianna AGUDELO; Andrea JURADO; Avery PEACE; Yu E LEE; Anna GAZUMYAN; Francesca GUIDETTI; Jasmine CANTERGIANI; Benedetta CENA; Filippo BIANCHINI; Elia TAMAGNINI; Simone G MORO; Pavel SVOBODA; Federico COSTA; Mitermayer G REIS; Albert I KO; Brian A FALLON; Santiago AVILA-RIOS; Gustavo REYES-TERAN; Charles M RICE; Michel C NUSSENZWEIG; Pamela J BJORKMAN; Daniel RŮŽEK; Luca VARANI; Margaret R MACDONALD a Davide F ROBBIANI. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2024, roč.~43, č.~6, s.~1-18. ISSN~2211-1247. Dostupné z: https://doi.org/10.1016/j.celrep.2024.114298.

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