Causes of ventilatory inefficiency in lung resection
candidates.

J 2025

Causes of ventilatory inefficiency in lung resection candidates.

BARTOŠ, Štěpán; Michal SVOBODA; Kristián BRAT; Marek LUKEŠ; Adam PREDÁČ et al.

Základní údaje

Originální název

Causes of ventilatory inefficiency in lung resection candidates.

Autoři

BARTOŠ, Štěpán; Michal SVOBODA; Kristián BRAT; Marek LUKEŠ; Adam PREDÁČ; Pavel HOMOLKA; Olson LYLE a Ivan ČUNDRLE

Vydání

ERJ Open Research, SHEFFIELD, EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2025, 2312-0541

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.000 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140639

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

ventilatory inefficiency; lung resection candidates

Štítky

14110118, 14110122, 14110215, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 1. 2026 13:58, Mgr. Tereza Miškechová

Anotace

V originále

Introduction Ventilatory efficiency (V′E/V′CO2) has been shown to predict postoperative pulmonary complications (PPCs) in lung resection candidates. V′E/V′CO2 is determined by arterial partial pressure of carbon dioxide (PaCO2) and by dead space to tidal volume ratio (VD/VT). We hypothesised PaCO2 and VD/VT contribute equally to the increase in V′E/V′CO2 in lung resection patients. Methods Consecutive lung resection candidates from two prior prospective studies were included in this post hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercise testing and arterial blood gas analysis at rest and peak exercise. PPCs were prospectively assessed during the first 30 postoperative days, or hospital stay. A t-test, Mann–Whitney U-test and two-tailed Fisher's exact test were used to compare patients with and without PPCs. p-values <0.05 were considered statistically significant. Results Of 398 patients, PPC developed in 64 (16%). Patients with PPCs more frequently underwent lobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30- and 90-day mortality. Moreover, patients with PPCs exhibited a higher V′E/V′CO2 ratio both at rest and peak exercise. Both ratios were independently associated with PPCs. At rest, the contribution of PaCO2 and VD/VT to the increase in V′E/V′CO2 ratio in patients with PPCs was 45% and 55%, respectively. At peak exercise, the contribution of PaCO2 and VD/VT to the increase in V′E/V′CO2 ratio was 16% and 84%, respectively. Conclusions VD/VT (V′/Q′ mismatch and/or rapid shallow breathing pattern) is the dominant contributor to the increase in V′E/V′CO2 in lung resection candidates who develop PPCs.

Návaznosti

MUNI/A/1447/2024, interní kód MU

Název: Využití parametrů dýchání v klidu, během zátěže a během spánku pro predikci perioperačnícho outcome a optimalizaci.

Investor: Masarykova univerzita, Využití parametrů dýchání v klidu, během zátěže a během spánku pro predikci perioperačnícho outcome a optimalizaci.

Citovat

BARTOŠ, Štěpán; Michal SVOBODA; Kristián BRAT; Marek LUKEŠ; Adam PREDÁČ; Pavel HOMOLKA; Olson LYLE a Ivan ČUNDRLE. Causes of ventilatory inefficiency in lung resection candidates. ERJ Open Research. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2025, roč. 11, č. 2, s. 1-9. ISSN 2312-0541. Dostupné z: https://doi.org/10.1183/23120541.00792-2024.

@article{2476457,
   author = {Bartoš, Štěpán and Svoboda, Michal and Brat, Kristián and Lukeš, Marek and Predáč, Adam and Homolka, Pavel and Lyle, Olson and Čundrle, Ivan},
   article_location = {SHEFFIELD},
   article_number = {2},
   doi = {https://doi.org/10.1183/23120541.00792-2024},
   keywords = {ventilatory inefficiency; lung resection candidates},
   language = {eng},
   issn = {2312-0541},
   journal = {ERJ Open Research},
   title = {Causes of ventilatory inefficiency in lung resection candidates.},
   url = {https://publications.ersnet.org/content/erjor/11/2/00792-2024?implicit-login=true%26198},
   volume = {11},
   year = {2025}
}

TY  - JOUR
ID  - 2476457
AU  - Bartoš, Štěpán - Svoboda, Michal - Brat, Kristián - Lukeš, Marek - Predáč, Adam - Homolka, Pavel - Lyle, Olson - Čundrle, Ivan
PY  - 2025
TI  - Causes of ventilatory inefficiency in lung resection candidates.
JF  - ERJ Open Research
VL  - 11
IS  - 2
SP  - 1-9
EP  - 1-9
PB  - EUROPEAN RESPIRATORY SOC JOURNALS LTD
SN  - 23120541
KW  - ventilatory inefficiency
KW  - lung resection candidates
UR  - https://publications.ersnet.org/content/erjor/11/2/00792-2024?implicit-login=true%26198
N2  - Introduction Ventilatory efficiency (V′E/V′CO2) has been shown to predict postoperative pulmonary complications (PPCs) in lung resection candidates. V′E/V′CO2 is determined by arterial partial pressure of carbon dioxide (PaCO2) and by dead space to tidal volume ratio (VD/VT). We hypothesised PaCO2 and VD/VT contribute equally to the increase in V′E/V′CO2 in lung resection patients. Methods Consecutive lung resection candidates from two prior prospective studies were included in this post hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercise testing and arterial blood gas analysis at rest and peak exercise. PPCs were prospectively assessed during the first 30 postoperative days, or hospital stay. A t-test, Mann–Whitney U-test and two-tailed Fisher's exact test were used to compare patients with and without PPCs. p-values <0.05 were considered statistically significant. Results Of 398 patients, PPC developed in 64 (16%). Patients with PPCs more frequently underwent lobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30- and 90-day mortality. Moreover, patients with PPCs exhibited a higher V′E/V′CO2 ratio both at rest and peak exercise. Both ratios were independently associated with PPCs. At rest, the contribution of PaCO2 and VD/VT to the increase in V′E/V′CO2 ratio in patients with PPCs was 45% and 55%, respectively. At peak exercise, the contribution of PaCO2 and VD/VT to the increase in V′E/V′CO2 ratio was 16% and 84%, respectively. Conclusions VD/VT (V′/Q′ mismatch and/or rapid shallow breathing pattern) is the dominant contributor to the increase in V′E/V′CO2 in lung resection candidates who develop PPCs.
ER  -

BARTOŠ, Štěpán; Michal SVOBODA; Kristián BRAT; Marek LUKEŠ; Adam PREDÁČ; Pavel HOMOLKA; Olson LYLE a Ivan ČUNDRLE. Causes of ventilatory inefficiency in lung resection candidates. \textit{ERJ Open Research}. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2025, roč.~11, č.~2, s.~1-9. ISSN~2312-0541. Dostupné z: https://doi.org/10.1183/23120541.00792-2024.

Přehled o publikaci