Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
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HUGGINS, Ashley A; C Lexi BAIRD; Melvin BRIGGS; Sarah LASKOWITZ; Ahmed HUSSAIN; Samar FOUDA; Courtney HASWELL; Delin SUN; Lauren E SALMINEN; Neda JAHANSHAD; Sophia I THOMOPOULOS; Dick J VELTMAN; Jessie L FRIJLING; Miranda OLFF; van Zuiden MIRJAM; Saskia B J KOCH; Laura NAWJIN; Li WANG; Ye ZHU; Gen LI; Dan J STEIN; Jonathan IPSER; Soraya SEEDAT; Stefan DU PLESSIS; Leigh L. VAN DEN HEUVEL; Benjamin SUAREZ-JIMENEZ; Xi ZHU; Yoojean KIM; Xiaofu HE; Sigal ZILCHA-MANO; Amit LAZAROV; Yuval NERIA; Jennifer S. STEVENS; Kerry J. RESSLER; Tanja JOVANOVIC; Sanne J.H. VAN ROOIJ SANNE; Negar FANI; Anna R HUDSON; Sven C MUELLER; Anika SIERK; Antje MANTHEY; Henrik WALTER; Judith K DANIELS; Christian SCHMAHL; Julia I HERZOG; Pavel ŘÍHA; Ivan REKTOR; Lauren A M LEBOIS; Milissa L KAUFMAN; Elizabeth A OLSON; Justin T BAKER; Isabelle M ROSSO; Anthony P KING; Isreal LIBERZON; Mike ANGSTADT; Nicholas D DAVENPORT; Scott R SPONHEIM; Seth G DISNER; Thomas STRAUBE; David HOFMANN; Rongfeng QI; Guang Ming LU; Lee A BAUGH; Gina L FORSTER; Raluca M SIMONS; Jeffrey S SIMONS; Vincent A MAGNOTTA; Kelene A FERCHO; Adi MARON-KATZ; Amit ETKIN; Andrew S COTTON; Erin N O'LEARY; Hong XIE; Xin WANG; Yann QUIDE; Wissam EL-HAGE; Shmuel LISSEK; Hannah BERG; Steven BRUCE; Josh CISLER; Marisa ROSS; Ryan J HERRINGA; Daniel W GRUPE; Jack B NITSCHKE; Richard J DAVIDSON; Christine L LARSON; Terri A DEROON-CASSINI; Carissa W TOMAS; Jacklynn M FITZGERALD; Jennifer Urbano BLACKFORD; Bunmi O OLATUNJI; William S KREMEN; Michael J LYONS; Carol E FRANZ; Evan M GORDON; Geoffrey MAY; Steven M NELSON; Chadi G ABDALLAH; Ifat LEVY; Ilan HARPAZ-ROTEM; John H KRYSTAL; Emily L DENNIS; David F TATE; David X CIFU; William C WALKER; Elizabeth A WILDE; Ian H HARDING; Rebecca KERESTES; Paul M THOMPSON a Rajendra MOREY
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p(-FDR) < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.
Návaznosti
NV18-04-00559, projekt VaV
Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků
Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků
HUGGINS, Ashley A; C Lexi BAIRD; Melvin BRIGGS; Sarah LASKOWITZ; Ahmed HUSSAIN; Samar FOUDA; Courtney HASWELL; Delin SUN; Lauren E SALMINEN; Neda JAHANSHAD; Sophia I THOMOPOULOS; Dick J VELTMAN; Jessie L FRIJLING; Miranda OLFF; van Zuiden MIRJAM; Saskia B J KOCH; Laura NAWJIN; Li WANG; Ye ZHU; Gen LI; Dan J STEIN; Jonathan IPSER; Soraya SEEDAT; Stefan DU PLESSIS; Leigh L. VAN DEN HEUVEL; Benjamin SUAREZ-JIMENEZ; Xi ZHU; Yoojean KIM; Xiaofu HE; Sigal ZILCHA-MANO; Amit LAZAROV; Yuval NERIA; Jennifer S. STEVENS; Kerry J. RESSLER; Tanja JOVANOVIC; Sanne J.H. VAN ROOIJ SANNE; Negar FANI; Anna R HUDSON; Sven C MUELLER; Anika SIERK; Antje MANTHEY; Henrik WALTER; Judith K DANIELS; Christian SCHMAHL; Julia I HERZOG; Pavel ŘÍHA; Ivan REKTOR; Lauren A M LEBOIS; Milissa L KAUFMAN; Elizabeth A OLSON; Justin T BAKER; Isabelle M ROSSO; Anthony P KING; Isreal LIBERZON; Mike ANGSTADT; Nicholas D DAVENPORT; Scott R SPONHEIM; Seth G DISNER; Thomas STRAUBE; David HOFMANN; Rongfeng QI; Guang Ming LU; Lee A BAUGH; Gina L FORSTER; Raluca M SIMONS; Jeffrey S SIMONS; Vincent A MAGNOTTA; Kelene A FERCHO; Adi MARON-KATZ; Amit ETKIN; Andrew S COTTON; Erin N O'LEARY; Hong XIE; Xin WANG; Yann QUIDE; Wissam EL-HAGE; Shmuel LISSEK; Hannah BERG; Steven BRUCE; Josh CISLER; Marisa ROSS; Ryan J HERRINGA; Daniel W GRUPE; Jack B NITSCHKE; Richard J DAVIDSON; Christine L LARSON; Terri A DEROON-CASSINI; Carissa W TOMAS; Jacklynn M FITZGERALD; Jennifer Urbano BLACKFORD; Bunmi O OLATUNJI; William S KREMEN; Michael J LYONS; Carol E FRANZ; Evan M GORDON; Geoffrey MAY; Steven M NELSON; Chadi G ABDALLAH; Ifat LEVY; Ilan HARPAZ-ROTEM; John H KRYSTAL; Emily L DENNIS; David F TATE; David X CIFU; William C WALKER; Elizabeth A WILDE; Ian H HARDING; Rebecca KERESTES; Paul M THOMPSON a Rajendra MOREY. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry. London: Nature Publishing Group, 2024, roč. 29, č. 3, s. 611-623. ISSN 1359-4184. Dostupné z: https://doi.org/10.1038/s41380-023-02352-0.
@article{2476939, author = {Huggins, Ashley A and Baird, C Lexi and Briggs, Melvin and Laskowitz, Sarah and Hussain, Ahmed and Fouda, Samar and Haswell, Courtney and Sun, Delin and Salminen, Lauren E and Jahanshad, Neda and Thomopoulos, Sophia I and Veltman, Dick J and Frijling, Jessie L and Olff, Miranda and Mirjam, van Zuiden and Koch, Saskia B J and Nawjin, Laura and Wang, Li and Zhu, Ye and Li, Gen and Stein, Dan J and Ipser, Jonathan and Seedat, Soraya and du Plessis, Stefan and van den Heuvel, Leigh L. and SuarezandJimenez, Benjamin and Zhu, Xi and Kim, Yoojean and He, Xiaofu and ZilchaandMano, Sigal and Lazarov, Amit and Neria, Yuval and Stevens, Jennifer S. and Ressler, Kerry J. and Jovanovic, Tanja and van Rooij Sanne, Sanne J.H. and Fani, Negar and Hudson, Anna R and Mueller, Sven C and Sierk, Anika and Manthey, Antje and Walter, Henrik and Daniels, Judith K and Schmahl, Christian and Herzog, Julia I and Říha, Pavel and Rektor, Ivan and Lebois, Lauren A M and Kaufman, Milissa L and Olson, Elizabeth A and Baker, Justin T and Rosso, Isabelle M and King, Anthony P and Liberzon, Isreal and Angstadt, Mike and Davenport, Nicholas D and Sponheim, Scott R and Disner, Seth G and Straube, Thomas and Hofmann, David and Qi, Rongfeng and Lu, Guang Ming and Baugh, Lee A and Forster, Gina L and Simons, Raluca M and Simons, Jeffrey S and Magnotta, Vincent A and Fercho, Kelene A and MaronandKatz, Adi and Etkin, Amit and Cotton, Andrew S and O'Leary, Erin N and Xie, Hong and Wang, Xin and Quide, Yann and ElandHage, Wissam and Lissek, Shmuel and Berg, Hannah and Bruce, Steven and Cisler, Josh and Ross, Marisa and Herringa, Ryan J and Grupe, Daniel W and Nitschke, Jack B and Davidson, Richard J and Larson, Christine L and deRoonandCassini, Terri A and Tomas, Carissa W and Fitzgerald, Jacklynn M and Blackford, Jennifer Urbano and Olatunji, Bunmi O and Kremen, William S and Lyons, Michael J and Franz, Carol E and Gordon, Evan M and May, Geoffrey and Nelson, Steven M and Abdallah, Chadi G and Levy, Ifat and HarpazandRotem, Ilan and Krystal, John H and Dennis, Emily L and Tate, David F and Cifu, David X and Walker, William C and Wilde, Elizabeth A and Harding, Ian H and Kerestes, Rebecca and Thompson, Paul M and Morey, Rajendra}, article_location = {London}, article_number = {3}, doi = {https://doi.org/10.1038/s41380-023-02352-0}, keywords = {HIPPOCAMPAL VOLUME; FUNCTIONAL TOPOGRAPHY; DISSOCIATIVE SUBTYPE; FEAR; BRAIN; CONNECTIVITY; METAANALYSIS; AMYGDALA; EXTINCTION; CINGULATE}, language = {eng}, issn = {1359-4184}, journal = {Molecular Psychiatry}, title = {Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup}, url = {https://www.nature.com/articles/s41380-023-02352-0}, volume = {29}, year = {2024} }
TY - JOUR ID - 2476939 AU - Huggins, Ashley A - Baird, C Lexi - Briggs, Melvin - Laskowitz, Sarah - Hussain, Ahmed - Fouda, Samar - Haswell, Courtney - Sun, Delin - Salminen, Lauren E - Jahanshad, Neda - Thomopoulos, Sophia I - Veltman, Dick J - Frijling, Jessie L - Olff, Miranda - Mirjam, van Zuiden - Koch, Saskia B J - Nawjin, Laura - Wang, Li - Zhu, Ye - Li, Gen - Stein, Dan J - Ipser, Jonathan - Seedat, Soraya - du Plessis, Stefan - van den Heuvel, Leigh L. - Suarez-Jimenez, Benjamin - Zhu, Xi - Kim, Yoojean - He, Xiaofu - Zilcha-Mano, Sigal - Lazarov, Amit - Neria, Yuval - Stevens, Jennifer S. - Ressler, Kerry J. - Jovanovic, Tanja - van Rooij Sanne, Sanne J.H. - Fani, Negar - Hudson, Anna R - Mueller, Sven C - Sierk, Anika - Manthey, Antje - Walter, Henrik - Daniels, Judith K - Schmahl, Christian - Herzog, Julia I - Říha, Pavel - Rektor, Ivan - Lebois, Lauren A M - Kaufman, Milissa L - Olson, Elizabeth A - Baker, Justin T - Rosso, Isabelle M - King, Anthony P - Liberzon, Isreal - Angstadt, Mike - Davenport, Nicholas D - Sponheim, Scott R - Disner, Seth G - Straube, Thomas - Hofmann, David - Qi, Rongfeng - Lu, Guang Ming - Baugh, Lee A - Forster, Gina L - Simons, Raluca M - Simons, Jeffrey S - Magnotta, Vincent A - Fercho, Kelene A - Maron-Katz, Adi - Etkin, Amit - Cotton, Andrew S - O'Leary, Erin N - Xie, Hong - Wang, Xin - Quide, Yann - El-Hage, Wissam - Lissek, Shmuel - Berg, Hannah - Bruce, Steven - Cisler, Josh - Ross, Marisa - Herringa, Ryan J - Grupe, Daniel W - Nitschke, Jack B - Davidson, Richard J - Larson, Christine L - deRoon-Cassini, Terri A - Tomas, Carissa W - Fitzgerald, Jacklynn M - Blackford, Jennifer Urbano - Olatunji, Bunmi O - Kremen, William S - Lyons, Michael J - Franz, Carol E - Gordon, Evan M - May, Geoffrey - Nelson, Steven M - Abdallah, Chadi G - Levy, Ifat - Harpaz-Rotem, Ilan - Krystal, John H - Dennis, Emily L - Tate, David F - Cifu, David X - Walker, William C - Wilde, Elizabeth A - Harding, Ian H - Kerestes, Rebecca - Thompson, Paul M - Morey, Rajendra PY - 2024 TI - Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup JF - Molecular Psychiatry VL - 29 IS - 3 SP - 611-623 EP - 611-623 PB - Nature Publishing Group SN - 13594184 KW - HIPPOCAMPAL VOLUME KW - FUNCTIONAL TOPOGRAPHY KW - DISSOCIATIVE SUBTYPE KW - FEAR KW - BRAIN KW - CONNECTIVITY KW - METAANALYSIS KW - AMYGDALA KW - EXTINCTION KW - CINGULATE UR - https://www.nature.com/articles/s41380-023-02352-0 N2 - Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p(-FDR) < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD. ER -
HUGGINS, Ashley A; C Lexi BAIRD; Melvin BRIGGS; Sarah LASKOWITZ; Ahmed HUSSAIN; Samar FOUDA; Courtney HASWELL; Delin SUN; Lauren E SALMINEN; Neda JAHANSHAD; Sophia I THOMOPOULOS; Dick J VELTMAN; Jessie L FRIJLING; Miranda OLFF; van Zuiden MIRJAM; Saskia B J KOCH; Laura NAWJIN; Li WANG; Ye ZHU; Gen LI; Dan J STEIN; Jonathan IPSER; Soraya SEEDAT; Stefan DU PLESSIS; Leigh L. VAN DEN HEUVEL; Benjamin SUAREZ-JIMENEZ; Xi ZHU; Yoojean KIM; Xiaofu HE; Sigal ZILCHA-MANO; Amit LAZAROV; Yuval NERIA; Jennifer S. STEVENS; Kerry J. RESSLER; Tanja JOVANOVIC; Sanne J.H. VAN ROOIJ SANNE; Negar FANI; Anna R HUDSON; Sven C MUELLER; Anika SIERK; Antje MANTHEY; Henrik WALTER; Judith K DANIELS; Christian SCHMAHL; Julia I HERZOG; Pavel ŘÍHA; Ivan REKTOR; Lauren A M LEBOIS; Milissa L KAUFMAN; Elizabeth A OLSON; Justin T BAKER; Isabelle M ROSSO; Anthony P KING; Isreal LIBERZON; Mike ANGSTADT; Nicholas D DAVENPORT; Scott R SPONHEIM; Seth G DISNER; Thomas STRAUBE; David HOFMANN; Rongfeng QI; Guang Ming LU; Lee A BAUGH; Gina L FORSTER; Raluca M SIMONS; Jeffrey S SIMONS; Vincent A MAGNOTTA; Kelene A FERCHO; Adi MARON-KATZ; Amit ETKIN; Andrew S COTTON; Erin N O'LEARY; Hong XIE; Xin WANG; Yann QUIDE; Wissam EL-HAGE; Shmuel LISSEK; Hannah BERG; Steven BRUCE; Josh CISLER; Marisa ROSS; Ryan J HERRINGA; Daniel W GRUPE; Jack B NITSCHKE; Richard J DAVIDSON; Christine L LARSON; Terri A DEROON-CASSINI; Carissa W TOMAS; Jacklynn M FITZGERALD; Jennifer Urbano BLACKFORD; Bunmi O OLATUNJI; William S KREMEN; Michael J LYONS; Carol E FRANZ; Evan M GORDON; Geoffrey MAY; Steven M NELSON; Chadi G ABDALLAH; Ifat LEVY; Ilan HARPAZ-ROTEM; John H KRYSTAL; Emily L DENNIS; David F TATE; David X CIFU; William C WALKER; Elizabeth A WILDE; Ian H HARDING; Rebecca KERESTES; Paul M THOMPSON a Rajendra MOREY. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. \textit{Molecular Psychiatry}. London: Nature Publishing Group, 2024, roč.~29, č.~3, s.~611-623. ISSN~1359-4184. Dostupné z: https://doi.org/10.1038/s41380-023-02352-0.