Dietary exposure to 17α-ethinylestradiol negatively affects
reproduction and health parameters of zebrafish (Danio rerio)

J 2025

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK et al.

Základní údaje

Originální název

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Autoři

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK; František TICHÝ; Aleš FRANC; Zdeňka SVOBODOVÁ a Jana BLÁHOVÁ

Vydání

Journal of Fish Biology, HOBOKEN, Academic Press, 2025, 0022-1112

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

40103 Fishery

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.000 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00140764

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

17 alpha-ethinylestradiol; fish; gene expression; histopathology; oestrogens; oxidative stress

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 3. 2026 15:17, Mgr. Irena Doubková

Anotace

V originále

Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.

Citovat

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK; František TICHÝ; Aleš FRANC; Zdeňka SVOBODOVÁ a Jana BLÁHOVÁ. Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio). Journal of Fish Biology. HOBOKEN: Academic Press, 2025, roč. 106, č. 6, s. 1831-1844. ISSN 0022-1112. Dostupné z: https://doi.org/10.1111/jfb.16065.

@article{2482003,
   author = {Hollerová, Aneta and Pešková, Nikola and Weiserová, Zuzana and Hodkovicová, Nikola and Maršálek, Petr and Tichý, František and Franc, Aleš and Svobodová, Zdeňka and Bláhová, Jana},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {https://doi.org/10.1111/jfb.16065},
   keywords = {17 alpha-ethinylestradiol; fish; gene expression; histopathology; oestrogens; oxidative stress},
   language = {eng},
   issn = {0022-1112},
   journal = {Journal of Fish Biology},
   title = {Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065},
   volume = {106},
   year = {2025}
}

TY  - JOUR
ID  - 2482003
AU  - Hollerová, Aneta - Pešková, Nikola - Weiserová, Zuzana - Hodkovicová, Nikola - Maršálek, Petr - Tichý, František - Franc, Aleš - Svobodová, Zdeňka - Bláhová, Jana
PY  - 2025
TI  - Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)
JF  - Journal of Fish Biology
VL  - 106
IS  - 6
SP  - 1831-1844
EP  - 1831-1844
PB  - Academic Press
SN  - 00221112
KW  - 17 alpha-ethinylestradiol
KW  - fish
KW  - gene expression
KW  - histopathology
KW  - oestrogens
KW  - oxidative stress
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065
N2  - Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.
ER  -

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK; František TICHÝ; Aleš FRANC; Zdeňka SVOBODOVÁ a Jana BLÁHOVÁ. Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio). \textit{Journal of Fish Biology}. HOBOKEN: Academic Press, 2025, roč.~106, č.~6, s.~1831-1844. ISSN~0022-1112. Dostupné z: https://doi.org/10.1111/jfb.16065.

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