Bioprostheses and Mechanical Prostheses for Aortic Valve
Replacement in Patients Aged 50 to 65 Years Offer Similar
Long-Term Survival Rates

J 2025

Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates

TOPORCER, Tomas; Stefan LUKACIN; Andrea KRAUS; Marian HOMOLA; Anton BERES et al.

Základní údaje

Originální název

Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates

Autoři

TOPORCER, Tomas; Stefan LUKACIN; Andrea KRAUS; Marian HOMOLA; Anton BERES; Michal TREBISOVSKY; Denis RADOTZY; Vilem ROHN a Adrian KOLESAR

Vydání

Journal of Cardiovascular Development and Disease, Basel, MDPI, 2025, 2308-3425

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.300 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00140825

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

aortic valve replacement; aortic valve stenosis; mechanical prosthesis; bioprosthesis

Štítky

14311010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2025 16:16, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Background: Aortic valve replacement (AVR) is the definitive therapy for patients with severe aortic valve stenosis (AoS). The aim of this work is to compare the effect of a mechanical prosthesis (MP) and a bioprosthesis (BP) on the survival of patients aged 50–65 years after AVR. Methods: The retrospective analysis included 276 patients aged 50 to 65 years who had undergone isolated AVR for AoS; 161 patients were implanted with an MP and 115 with a BP. Patient survival, adjusted for age, gender and risk parameters affecting survival, was assessed. A subgroup analysis was performed on the 208 patients with a modern valve (prosthesis models that are no longer used in clinical practice were removed from the sample). Results: After adjusting for risk factors for overall survival as well as for age and sex, the implantation of an MP did not have a significant effect on overall survival in comparison to a BP, at a median follow-up of 10.3 years (p = 0.477). The size of the MP had no significant effect on overall survival either (HR: 1.29; 95%CI: 0.16–10.21; p = 0.812). However, the indexed effective orifice area of the BP had a positive effect on overall survival (HR: 0.09; 95%CI: 0.01–0.78; p = 0.029). Conclusions: The estimated survival of patients aged between 50 and 65 years after implantation of a BP with a sufficiently large indexed effective orifice area may exceed that of patients with an MP.

Citovat

TOPORCER, Tomas; Stefan LUKACIN; Andrea KRAUS; Marian HOMOLA; Anton BERES; Michal TREBISOVSKY; Denis RADOTZY; Vilem ROHN a Adrian KOLESAR. Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates. Journal of Cardiovascular Development and Disease. Basel: MDPI, 2025, roč. 12, č. 2, s. 1-14. ISSN 2308-3425. Dostupné z: https://doi.org/10.3390/jcdd12020044.

@article{2483477,
   author = {Toporcer, Tomas and Lukacin, Stefan and Kraus, Andrea and Homola, Marian and Beres, Anton and Trebisovsky, Michal and Radotzy, Denis and Rohn, Vilem and Kolesar, Adrian},
   article_location = {Basel},
   article_number = {2},
   doi = {https://doi.org/10.3390/jcdd12020044},
   keywords = {aortic valve replacement; aortic valve stenosis; mechanical prosthesis; bioprosthesis},
   language = {eng},
   issn = {2308-3425},
   journal = {Journal of Cardiovascular Development and Disease},
   title = {Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates},
   url = {https://doi.org/10.3390/jcdd12020044},
   volume = {12},
   year = {2025}
}

TY  - JOUR
ID  - 2483477
AU  - Toporcer, Tomas - Lukacin, Stefan - Kraus, Andrea - Homola, Marian - Beres, Anton - Trebisovsky, Michal - Radotzy, Denis - Rohn, Vilem - Kolesar, Adrian
PY  - 2025
TI  - Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates
JF  - Journal of Cardiovascular Development and Disease
VL  - 12
IS  - 2
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 23083425
KW  - aortic valve replacement
KW  - aortic valve stenosis
KW  - mechanical prosthesis
KW  - bioprosthesis
UR  - https://doi.org/10.3390/jcdd12020044
N2  - Background: Aortic valve replacement (AVR) is the definitive therapy for patients with severe aortic valve stenosis (AoS). The aim of this work is to compare the effect of a mechanical prosthesis (MP) and a bioprosthesis (BP) on the survival of patients aged 50–65 years after AVR. Methods: The retrospective analysis included 276 patients aged 50 to 65 years who had undergone isolated AVR for AoS; 161 patients were implanted with an MP and 115 with a BP. Patient survival, adjusted for age, gender and risk parameters affecting survival, was assessed. A subgroup analysis was performed on the 208 patients with a modern valve (prosthesis models that are no longer used in clinical practice were removed from the sample). Results: After adjusting for risk factors for overall survival as well as for age and sex, the implantation of an MP did not have a significant effect on overall survival in comparison to a BP, at a median follow-up of 10.3 years (p = 0.477). The size of the MP had no significant effect on overall survival either (HR: 1.29; 95%CI: 0.16–10.21; p = 0.812). However, the indexed effective orifice area of the BP had a positive effect on overall survival (HR: 0.09; 95%CI: 0.01–0.78; p = 0.029). Conclusions: The estimated survival of patients aged between 50 and 65 years after implantation of a BP with a sufficiently large indexed effective orifice area may exceed that of patients with an MP.
ER  -

TOPORCER, Tomas; Stefan LUKACIN; Andrea KRAUS; Marian HOMOLA; Anton BERES; Michal TREBISOVSKY; Denis RADOTZY; Vilem ROHN a Adrian KOLESAR. Bioprostheses and Mechanical Prostheses for Aortic Valve Replacement in Patients Aged 50 to 65 Years Offer Similar Long-Term Survival Rates. \textit{Journal of Cardiovascular Development and Disease}. Basel: MDPI, 2025, roč.~12, č.~2, s.~1-14. ISSN~2308-3425. Dostupné z: https://doi.org/10.3390/jcdd12020044.

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