Controlling the transmembrane transport of chloride by dynamic
covalent chemistry with azines

J 2025

Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA; Hennie VALKENIER et. al.

Základní údaje

Originální název

Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines

Autoři

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA (703 Slovensko, garant, domácí) a Hennie VALKENIER

Vydání

Chemical Science, Cambridge, Royal Society of Chemistry, 2025, 2041-6520

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.600 v roce 2023

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1039/d4sc08580a

UT WoS

001406102200001

EID Scopus

2-s2.0-85216393604

Klíčová slova anglicky

ANION TRANSPORTERS; PROSPECTS; POLYMERS; VESICLES

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2025 11:06, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes. An active chloride transporter was obtained in situ within the lipid bilayer by dynamic azine metathesis. The transport activity was further tuned by changing the structure of the added azines, while the dynamic covalent chemistry could be activated by lowering the pH. This dynamic covalent chemistry opens a new approach towards controlling transmembrane transport.

Citovat

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA a Hennie VALKENIER. Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines. Chemical Science. Cambridge: Royal Society of Chemistry, 2025, roč. 16, č. 8, s. 3509-3515. ISSN 2041-6520. Dostupné z: https://dx.doi.org/10.1039/d4sc08580a.

@article{2483633,
   author = {Konopka, Marcin and Halgreen, Lau and Dascalu, AncaandElena and Chvojka, Matúš and Valkenier, Hennie},
   article_location = {Cambridge},
   article_number = {8},
   doi = {http://dx.doi.org/10.1039/d4sc08580a},
   keywords = {ANION TRANSPORTERS; PROSPECTS; POLYMERS; VESICLES},
   language = {eng},
   issn = {2041-6520},
   journal = {Chemical Science},
   title = {Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines},
   url = {https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08580a},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2483633
AU  - Konopka, Marcin - Halgreen, Lau - Dascalu, Anca-Elena - Chvojka, Matúš - Valkenier, Hennie
PY  - 2025
TI  - Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines
JF  - Chemical Science
VL  - 16
IS  - 8
SP  - 3509-3515
EP  - 3509-3515
PB  - Royal Society of Chemistry
SN  - 20416520
KW  - ANION TRANSPORTERS
KW  - PROSPECTS
KW  - POLYMERS
KW  - VESICLES
UR  - https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08580a
N2  - Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes. An active chloride transporter was obtained in situ within the lipid bilayer by dynamic azine metathesis. The transport activity was further tuned by changing the structure of the added azines, while the dynamic covalent chemistry could be activated by lowering the pH. This dynamic covalent chemistry opens a new approach towards controlling transmembrane transport.
ER  -

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA a Hennie VALKENIER. Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines. \textit{Chemical Science}. Cambridge: Royal Society of Chemistry, 2025, roč.~16, č.~8, s.~3509-3515. ISSN~2041-6520. Dostupné z: https://dx.doi.org/10.1039/d4sc08580a.

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