The e-STROKE Study: The Design of a Prospective Observational
Multicentral Study

J 2025

The e-STROKE Study: The Design of a Prospective Observational Multicentral Study

DVORNIKOVA, Katerina; Veronika KUNEŠOVÁ; Svatopluk OSTRY; Robert MIKULÍK; Michal BAR et. al.

Základní údaje

Originální název

The e-STROKE Study: The Design of a Prospective Observational Multicentral Study

Autoři

DVORNIKOVA, Katerina; Veronika KUNEŠOVÁ (203 Česká republika); Svatopluk OSTRY; Robert MIKULÍK (203 Česká republika); Michal BAR a STROCZECH Research CENTERS

Vydání

Journal of Cardiovascular Development and Disease, Basel, MDPI, 2025, 2308-3425

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

STROKE

Impakt faktor

Impact factor: 2.400 v roce 2023

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/jcdd12010017

UT WoS

001405872900001

Klíčová slova česky

stroke; CT imaging; multimodal CT; predictive value; CT perfusion; stroke mimics

Klíčová slova anglicky

stroke; CT imaging; multimodal CT; predictive value; CT perfusion; stroke mimics

Štítky

Excelence Science, FNUSA, LF MU Brno, RIV, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 3. 2025 09:27, Bc. Hana Vladíková, BBA

Anotace

V originále

Introduction: The e-STROKE study is a prospective, multicenter observational study designed to assess the impact of various CT parameters (including e-ASPECT, CT perfusion (CTP), collateral flow status, and the size and location of the ischemic lesion) on the clinical outcomes of patients with ischemic stroke, as evaluated by the modified Rankins Scale (mRS) three months post-stroke. This study also aims to investigate whether the use of multimodal CT imaging increases the number of patients eligible for recanalization therapy. The analysis will integrate data from the RES-Q registry and radiological data from the e-STROKE system provided by Brainomix Ltd. Aims: The primary aim is to determine the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, and ischemic lesion volume and location) on three-month functional outcomes, as defined by the mRS, in patients with non-lacunar stroke following recanalization treatment (IVT and/or MT). The secondary aim is to evaluate whether multimodal CT examination leads to an increase in the number of patients eligible for recanalization therapy. Additionally, this study seeks to assess the specificity and sensitivity of multimodal CT in distinguishing stroke mimics from actual strokes. Methods: This multicenter observational study involves patients with suspected acute ischemic stroke and a premorbid mRS <= 4, who are treated with endovascular thrombectomy (EVT), intravenous thrombolysis (IVT), or managed conservatively in stroke centers within the Czech Stroke Research Network (STROCZECH), which is part of the Czech Clinical Research Infrastructure Network (CZECRIN). Data collection includes demographic, clinical, and imaging data variables such as age, sex, ethnicity, risk factors, treatment times (OTT, DNT, and OGT), TICI scores, post-treatment hemorrhage (ECAS II), mRS outcome, stroke etiology, e-ASPECTS, acute ischemic volume (AIV), thrombus length on NCCT, CTA collateral score and collateral vessel density, location of large vessel occlusion, ischemic core, hypoperfusion volume, mismatch ratio and volume, final infarct volume, hemorrhage volume, and MRI in case of negative follow-up NCCT. Conclusions: We anticipate collecting robust clinical and radiological data from approximately 2000 patients across 22 centers over a 12-month period. The results are expected to enhance the precision of diagnostic and prognostic radiological markers in managing acute stroke.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

DVORNIKOVA, Katerina; Veronika KUNEŠOVÁ; Svatopluk OSTRY; Robert MIKULÍK; Michal BAR a STROCZECH Research CENTERS. The e-STROKE Study: The Design of a Prospective Observational Multicentral Study. Journal of Cardiovascular Development and Disease. Basel: MDPI, 2025, roč. 12, č. 1, s. 1-9. ISSN 2308-3425. Dostupné z: https://dx.doi.org/10.3390/jcdd12010017.

@article{2485137,
   author = {Dvornikova, Katerina and Kunešová, Veronika and Ostry, Svatopluk and Mikulík, Robert and Bar, Michal and Centers, STROCZECH Research},
   article_location = {Basel},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/jcdd12010017},
   keywords = {stroke; CT imaging; multimodal CT; predictive value; CT perfusion; stroke mimics},
   language = {eng},
   issn = {2308-3425},
   journal = {Journal of Cardiovascular Development and Disease},
   title = {The e-STROKE Study: The Design of a Prospective Observational Multicentral Study},
   url = {https://www.mdpi.com/2308-3425/12/1/17},
   volume = {12},
   year = {2025}
}

TY  - JOUR
ID  - 2485137
AU  - Dvornikova, Katerina - Kunešová, Veronika - Ostry, Svatopluk - Mikulík, Robert - Bar, Michal - Centers, STROCZECH Research
PY  - 2025
TI  - The e-STROKE Study: The Design of a Prospective Observational Multicentral Study
JF  - Journal of Cardiovascular Development and Disease
VL  - 12
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 23083425
KW  - stroke
KW  - CT imaging
KW  - multimodal CT
KW  - predictive value
KW  - CT perfusion
KW  - stroke mimics
UR  - https://www.mdpi.com/2308-3425/12/1/17
N2  - Introduction: The e-STROKE study is a prospective, multicenter observational study designed to assess the impact of various CT parameters (including e-ASPECT, CT perfusion (CTP), collateral flow status, and the size and location of the ischemic lesion) on the clinical outcomes of patients with ischemic stroke, as evaluated by the modified Rankins Scale (mRS) three months post-stroke. This study also aims to investigate whether the use of multimodal CT imaging increases the number of patients eligible for recanalization therapy. The analysis will integrate data from the RES-Q registry and radiological data from the e-STROKE system provided by Brainomix Ltd. Aims: The primary aim is to determine the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, and ischemic lesion volume and location) on three-month functional outcomes, as defined by the mRS, in patients with non-lacunar stroke following recanalization treatment (IVT and/or MT). The secondary aim is to evaluate whether multimodal CT examination leads to an increase in the number of patients eligible for recanalization therapy. Additionally, this study seeks to assess the specificity and sensitivity of multimodal CT in distinguishing stroke mimics from actual strokes. Methods: This multicenter observational study involves patients with suspected acute ischemic stroke and a premorbid mRS <= 4, who are treated with endovascular thrombectomy (EVT), intravenous thrombolysis (IVT), or managed conservatively in stroke centers within the Czech Stroke Research Network (STROCZECH), which is part of the Czech Clinical Research Infrastructure Network (CZECRIN). Data collection includes demographic, clinical, and imaging data variables such as age, sex, ethnicity, risk factors, treatment times (OTT, DNT, and OGT), TICI scores, post-treatment hemorrhage (ECAS II), mRS outcome, stroke etiology, e-ASPECTS, acute ischemic volume (AIV), thrombus length on NCCT, CTA collateral score and collateral vessel density, location of large vessel occlusion, ischemic core, hypoperfusion volume, mismatch ratio and volume, final infarct volume, hemorrhage volume, and MRI in case of negative follow-up NCCT. Conclusions: We anticipate collecting robust clinical and radiological data from approximately 2000 patients across 22 centers over a 12-month period. The results are expected to enhance the precision of diagnostic and prognostic radiological markers in managing acute stroke.
ER  -

DVORNIKOVA, Katerina; Veronika KUNEŠOVÁ; Svatopluk OSTRY; Robert MIKULÍK; Michal BAR a STROCZECH Research CENTERS. The e-STROKE Study: The Design of a Prospective Observational Multicentral Study. \textit{Journal of Cardiovascular Development and Disease}. Basel: MDPI, 2025, roč.~12, č.~1, s.~1-9. ISSN~2308-3425. Dostupné z: https://dx.doi.org/10.3390/jcdd12010017.

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