Perinatal Hypoxia and Immune System Activation in Schizophrenia
Pathogenesis: Critical Considerations During COVID-19 Pandemic

J 2024

Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic

KAWIKOVA, Ivana; Kristina HAKENOVA; Maria LEBEDEVA; Lenka KLETECKOVA; Lea JAKOB et. al.

Základní údaje

Originální název

Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic

Autoři

KAWIKOVA, Ivana; Kristina HAKENOVA; Maria LEBEDEVA; Lenka KLETECKOVA; Lea JAKOB; Vaclav SPICKA; Li WEN; Filip SPANIEL a Karel VALES

Vydání

Physiological research, Praha, Institute of Physiology of the Czechoslovak Academy of Sciences, 2024, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.900 v roce 2023

Kód RIV

RIV/00216224:90034/24:00139132

Organizační jednotka

CZECRIN

DOI

http://dx.doi.org/10.33549/physiolres.935501

UT WoS

001414553400011

Klíčová slova česky

Schizophrenia; Perinatal hypoxia; Perinatal infection; Microbiota; SARS-CoV-2

Klíčová slova anglicky

Schizophrenia; Perinatal hypoxia; Perinatal infection; Microbiota; SARS-CoV-2

Štítky

CZECRIN, Excelence Science, FN HK, NÚDZ, RIV, user

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 3. 2025 14:15, Bc. Hana Vladíková, BBA

Anotace

V originále

Schizophrenia, a severe psychiatric, neurodevelopmental disorder affecting about 0.29-1 % of the global population, is characterized by hallucinations, delusions, cognitive impairments, disorganized thoughts and speech, leading to significant social withdrawal and emotional blunting. During the 1980s, considerations about diseases that result from complex interactions of genetic background and environmental factors started to appear. One of the critical times of vulnerability is the perinatal period. Concerning schizophrenia, obstetric complications that are associated with hypoxia of the fetus or neonate were identified as a risk. Also, maternal infections during pregnancy were linked to schizophrenia by epidemiological, serologic and genetic studies. Research efforts then led to the development of experimental models testing the impact of perinatal hypoxia or maternal immune activation on neurodevelopmental disorders. These perinatal factors are usually studied separately, but given that the models are now validated, it is feasible to investigate both factors together. Inclusion of additional factors, such as metabolic disturbances or chronic stress, may need to be considered also. Understanding the interplay of perinatal factors in schizophrenia's etiology is crucial for developing targeted prevention and therapeutic strategies.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

KAWIKOVA, Ivana; Kristina HAKENOVA; Maria LEBEDEVA; Lenka KLETECKOVA; Lea JAKOB; Vaclav SPICKA; Li WEN; Filip SPANIEL a Karel VALES. Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic. Physiological research. Praha: Institute of Physiology of the Czechoslovak Academy of Sciences, 2024, roč. 73, č. 2, s. 615-639. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.935501.

@article{2485301,
   author = {Kawikova, Ivana and Hakenova, Kristina and Lebedeva, Maria and Kleteckova, Lenka and Jakob, Lea and Spicka, Vaclav and Wen, Li and Spaniel, Filip and Vales, Karel},
   article_location = {Praha},
   article_number = {2},
   doi = {http://dx.doi.org/10.33549/physiolres.935501},
   keywords = {Schizophrenia; Perinatal hypoxia; Perinatal infection; Microbiota; SARS-CoV-2},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological research},
   title = {Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic},
   url = {https://www.webofscience.com/wos/woscc/full-record/WOS:001414553400011},
   volume = {73},
   year = {2024}
}

TY  - JOUR
ID  - 2485301
AU  - Kawikova, Ivana - Hakenova, Kristina - Lebedeva, Maria - Kleteckova, Lenka - Jakob, Lea - Spicka, Vaclav - Wen, Li - Spaniel, Filip - Vales, Karel
PY  - 2024
TI  - Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic
JF  - Physiological research
VL  - 73
IS  - 2
SP  - 615-639
EP  - 615-639
PB  - Institute of Physiology of the Czechoslovak Academy of Sciences
SN  - 08628408
KW  - Schizophrenia
KW  - Perinatal hypoxia
KW  - Perinatal infection
KW  - Microbiota
KW  - SARS-CoV-2
UR  - https://www.webofscience.com/wos/woscc/full-record/WOS:001414553400011
N2  - Schizophrenia, a severe psychiatric, neurodevelopmental disorder affecting about 0.29-1 % of the global population, is characterized by hallucinations, delusions, cognitive impairments, disorganized thoughts and speech, leading to significant social withdrawal and emotional blunting. During the 1980s, considerations about diseases that result from complex interactions of genetic background and environmental factors started to appear. One of the critical times of vulnerability is the perinatal period. Concerning schizophrenia, obstetric complications that are associated with hypoxia of the fetus or neonate were identified as a risk. Also, maternal infections during pregnancy were linked to schizophrenia by epidemiological, serologic and genetic studies. Research efforts then led to the development of experimental models testing the impact of perinatal hypoxia or maternal immune activation on neurodevelopmental disorders. These perinatal factors are usually studied separately, but given that the models are now validated, it is feasible to investigate both factors together. Inclusion of additional factors, such as metabolic disturbances or chronic stress, may need to be considered also. Understanding the interplay of perinatal factors in schizophrenia's etiology is crucial for developing targeted prevention and therapeutic strategies.
ER  -

KAWIKOVA, Ivana; Kristina HAKENOVA; Maria LEBEDEVA; Lenka KLETECKOVA; Lea JAKOB; Vaclav SPICKA; Li WEN; Filip SPANIEL a Karel VALES. Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic. \textit{Physiological research}. Praha: Institute of Physiology of the Czechoslovak Academy of Sciences, 2024, roč.~73, č.~2, s.~615-639. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.935501.

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