Mitochondrial remodeling underlying age-induced skeletal muscle
wasting: let's talk about sex

J 2024

Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex

MOREIRA-PAIS, Alexandra; Rui VITORINO; Claudia SOUSA-MENDES; Maria Joao NEUPARTH; Alessandro NUCCIO et al.

Základní údaje

Originální název

Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex

Autoři

Vydání

Free Radical Biology and Medicine, NEW YORK, ELSEVIER SCIENCE INC, 2024, 0891-5849

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:90127/24:00139171

Organizační jednotka

CIISB II

Klíčová slova anglicky

Fatty acid oxidation; Mitophagy; Oxidative phosphorylation; Sarcopenia; Sexual dimorphism

Štítky

ne MU, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2025 18:05, Mgr. Eva Dubská

Anotace

V originále

Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the proteome profiling of mitochondria-enriched fractions. To the best of our knowledge, this is the first study analyzing sex differences in skeletal muscle mitochondrial proteome remodeling. Data demonstrated that age induced skeletal muscle atrophy and fibrosis in both sexes. In females, however, this adverse skeletal muscle remodeling was more accentuated than in males and might be attributed to an age-related reduction of 17beta-estradiol signaling through its estrogen receptor alpha located in mitochondria. The females-specific mitochondrial remodeling encompassed increased abundance of proteins involved in fatty acid oxidation, decreased abundance of the complexes subunits, and enhanced proneness to oxidative posttranslational modifications. This conceivable accretion of damaged mitochondria in old females might be ascribed to low levels of Parkin, a key mediator of mitophagy. Despite skeletal muscle atrophy and fibrosis, males maintained their testosterone levels throughout aging, as well as their androgen receptor content, and the age-induced mitochondrial remodeling was limited to increased abundance of pyruvate dehydrogenase E1 component subunit beta and electron transfer flavoprotein subunit beta. Herein, for the first time, it was demonstrated that age affects more severely the skeletal muscle mitochondrial proteome of females, reinforcing the necessity of sex-personalized approaches towards sarcopenia management, and the inevitability of the assessment of mitochondrion-related therapeutics.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

MOREIRA-PAIS, Alexandra; Rui VITORINO; Claudia SOUSA-MENDES; Maria Joao NEUPARTH; Alessandro NUCCIO; Claudio LUPARELLO; Alessandro ATTANZIO; Petr NOVAK; Dmitry LOGINOV; Rita NOGUEIRA-FERREIRA; Adelino LEITE-MOREIRA; Paula A OLIVEIRA; Rita FERREIRA a Rose A DUARTE. Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex. Free Radical Biology and Medicine. NEW YORK: ELSEVIER SCIENCE INC, 2024, roč. 218, jun, s. 68-81. ISSN 0891-5849. Dostupné z: https://doi.org/10.1016/j.freeradbiomed.2024.04.005.

@article{2486879,
   author = {MoreiraandPais, Alexandra and Vitorino, Rui and SousaandMendes, Claudia and Neuparth, Maria Joao and Nuccio, Alessandro and Luparello, Claudio and Attanzio, Alessandro and Novak, Petr and Loginov, Dmitry and NogueiraandFerreira, Rita and LeiteandMoreira, Adelino and Oliveira, Paula A and Ferreira, Rita and Duarte, Rose A},
   article_location = {NEW YORK},
   article_number = {jun},
   doi = {https://doi.org/10.1016/j.freeradbiomed.2024.04.005},
   keywords = {Fatty acid oxidation; Mitophagy; Oxidative phosphorylation; Sarcopenia; Sexual dimorphism},
   language = {eng},
   issn = {0891-5849},
   journal = {Free Radical Biology and Medicine},
   title = {Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex},
   url = {https://www.sciencedirect.com/science/article/pii/S0891584924001709?via%3Dihub},
   volume = {218},
   year = {2024}
}

TY  - JOUR
ID  - 2486879
AU  - Moreira-Pais, Alexandra - Vitorino, Rui - Sousa-Mendes, Claudia - Neuparth, Maria Joao - Nuccio, Alessandro - Luparello, Claudio - Attanzio, Alessandro - Novak, Petr - Loginov, Dmitry - Nogueira-Ferreira, Rita - Leite-Moreira, Adelino - Oliveira, Paula A - Ferreira, Rita - Duarte, Rose A
PY  - 2024
TI  - Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex
JF  - Free Radical Biology and Medicine
VL  - 218
IS  - jun
SP  - 68-81
EP  - 68-81
PB  - ELSEVIER SCIENCE INC
SN  - 08915849
KW  - Fatty acid oxidation
KW  - Mitophagy
KW  - Oxidative phosphorylation
KW  - Sarcopenia
KW  - Sexual dimorphism
UR  - https://www.sciencedirect.com/science/article/pii/S0891584924001709?via%3Dihub
N2  - Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the proteome profiling of mitochondria-enriched fractions. To the best of our knowledge, this is the first study analyzing sex differences in skeletal muscle mitochondrial proteome remodeling. Data demonstrated that age induced skeletal muscle atrophy and fibrosis in both sexes. In females, however, this adverse skeletal muscle remodeling was more accentuated than in males and might be attributed to an age-related reduction of 17beta-estradiol signaling through its estrogen receptor alpha located in mitochondria. The females-specific mitochondrial remodeling encompassed increased abundance of proteins involved in fatty acid oxidation, decreased abundance of the complexes subunits, and enhanced proneness to oxidative posttranslational modifications. This conceivable accretion of damaged mitochondria in old females might be ascribed to low levels of Parkin, a key mediator of mitophagy. Despite skeletal muscle atrophy and fibrosis, males maintained their testosterone levels throughout aging, as well as their androgen receptor content, and the age-induced mitochondrial remodeling was limited to increased abundance of pyruvate dehydrogenase E1 component subunit beta and electron transfer flavoprotein subunit beta. Herein, for the first time, it was demonstrated that age affects more severely the skeletal muscle mitochondrial proteome of females, reinforcing the necessity of sex-personalized approaches towards sarcopenia management, and the inevitability of the assessment of mitochondrion-related therapeutics.
ER  -

MOREIRA-PAIS, Alexandra; Rui VITORINO; Claudia SOUSA-MENDES; Maria Joao NEUPARTH; Alessandro NUCCIO; Claudio LUPARELLO; Alessandro ATTANZIO; Petr NOVAK; Dmitry LOGINOV; Rita NOGUEIRA-FERREIRA; Adelino LEITE-MOREIRA; Paula A OLIVEIRA; Rita FERREIRA a Rose A DUARTE. Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex. \textit{Free Radical Biology and Medicine}. NEW YORK: ELSEVIER SCIENCE INC, 2024, roč.~218, jun, s.~68-81. ISSN~0891-5849. Dostupné z: https://doi.org/10.1016/j.freeradbiomed.2024.04.005.

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