Experimental characterization of de novo proteins and their
unevolved random-sequence counterparts

J 2023

Experimental characterization of de novo proteins and their unevolved random-sequence counterparts

HEAMES, Brennen; Filip BUCHEL; Margaux AUBEL; Vyacheslav TRETYACHENKO; Dmitry LOGINOV et al.

Základní údaje

Originální název

Experimental characterization of de novo proteins and their unevolved random-sequence counterparts

Autoři

HEAMES, Brennen; Filip BUCHEL; Margaux AUBEL; Vyacheslav TRETYACHENKO; Dmitry LOGINOV; Petr NOVAK; Andreas LANGE; Erich BORNBERG-BAUER a Klara HLOUCHOVA

Vydání

NATURE ECOLOGY & EVOLUTION, BERLIN, NATURE PORTFOLIO, 2023, 2397-334X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 14.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:90127/23:00139187

Organizační jednotka

CIISB II

Klíčová slova anglicky

GENETIC SELECTION; AGGREGATION; PREDICTION; EVOLUTION; SIGNAL

Štítky

ne MU, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 3. 2025 09:11, Mgr. Eva Dubská

Anotace

V originále

While a bioinformatic comparison of de novo genes and synthetic random sequence does not identify a difference in biophysical properties, in vitro expression shows higher solubility for the de novo proteins, suggesting better integration into the cellular system than random sequences.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

HEAMES, Brennen; Filip BUCHEL; Margaux AUBEL; Vyacheslav TRETYACHENKO; Dmitry LOGINOV; Petr NOVAK; Andreas LANGE; Erich BORNBERG-BAUER a Klara HLOUCHOVA. Experimental characterization of de novo proteins and their unevolved random-sequence counterparts. NATURE ECOLOGY & EVOLUTION. BERLIN: NATURE PORTFOLIO, 2023, roč. 7, č. 4, s. 570-583. ISSN 2397-334X. Dostupné z: https://doi.org/10.1038/s41559-023-02010-2.

@article{2487181,
   author = {Heames, Brennen and Buchel, Filip and Aubel, Margaux and Tretyachenko, Vyacheslav and Loginov, Dmitry and Novak, Petr and Lange, Andreas and BornbergandBauer, Erich and Hlouchova, Klara},
   article_location = {BERLIN},
   article_number = {4},
   doi = {https://doi.org/10.1038/s41559-023-02010-2},
   keywords = {GENETIC SELECTION; AGGREGATION; PREDICTION; EVOLUTION; SIGNAL},
   language = {eng},
   issn = {2397-334X},
   journal = {NATURE ECOLOGY & EVOLUTION},
   title = {Experimental characterization of de novo proteins and their unevolved random-sequence counterparts},
   url = {https://www.nature.com/articles/s41559-023-02010-2},
   volume = {7},
   year = {2023}
}

TY  - JOUR
ID  - 2487181
AU  - Heames, Brennen - Buchel, Filip - Aubel, Margaux - Tretyachenko, Vyacheslav - Loginov, Dmitry - Novak, Petr - Lange, Andreas - Bornberg-Bauer, Erich - Hlouchova, Klara
PY  - 2023
TI  - Experimental characterization of de novo proteins and their unevolved random-sequence counterparts
JF  - NATURE ECOLOGY & EVOLUTION
VL  - 7
IS  - 4
SP  - 570-583
EP  - 570-583
PB  - NATURE PORTFOLIO
SN  - 2397334X
KW  - GENETIC SELECTION
KW  - AGGREGATION
KW  - PREDICTION
KW  - EVOLUTION
KW  - SIGNAL
UR  - https://www.nature.com/articles/s41559-023-02010-2
N2  - While a bioinformatic comparison of de novo genes and synthetic random sequence does not identify a difference in biophysical properties, in vitro expression shows higher solubility for the de novo proteins, suggesting better integration into the cellular system than random sequences.
ER  -

HEAMES, Brennen; Filip BUCHEL; Margaux AUBEL; Vyacheslav TRETYACHENKO; Dmitry LOGINOV; Petr NOVAK; Andreas LANGE; Erich BORNBERG-BAUER a Klara HLOUCHOVA. Experimental characterization of de novo proteins and their unevolved random-sequence counterparts. \textit{NATURE ECOLOGY \&{}amp; EVOLUTION}. BERLIN: NATURE PORTFOLIO, 2023, roč.~7, č.~4, s.~570-583. ISSN~2397-334X. Dostupné z: https://doi.org/10.1038/s41559-023-02010-2.

Přehled o publikaci