Structure of monkeypox virus poxin: implications for drug
design

J 2023

Structure of monkeypox virus poxin: implications for drug design

DUCHOSLAV, Vojtech a Evzen BOURA

Základní údaje

Originální název

Structure of monkeypox virus poxin: implications for drug design

Autoři

DUCHOSLAV, Vojtech a Evzen BOURA

Vydání

Archives of Virology, Wien, SPRINGER WIEN, 2023, 0304-8608

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:90242/23:00139191

Organizační jednotka

CIISB III

Klíčová slova anglicky

LENACAPAVIR; crystal structure; mpox poxin; binding site; inhibitors

Štítky

ne MU, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 3. 2025 09:57, Mgr. Eva Dubská

Anotace

V originále

Monkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine (JYNNEOS) and an effective drug (tecovirimat), concerns remain over the possible recurrence of a viral pandemic. Like any other virus, mpox virus must overcome the immune system to replicate. Viruses have evolved various strategies to overcome both innate and adaptive immunity. Poxviruses possess an unusual nuclease, poxin, which cleaves 2'-3'-cGAMP, a cyclic dinucleotide, which is an important second messenger in the cGAS-STING signaling pathway. Here, we present the crystal structure of mpox poxin. The structure reveals a conserved, predominantly ss- sheet fold and highlights the high conservation of the cGAMP binding site and of the catalytic residues His17, Tyr138, and Lys142. This research suggests that poxin inhibitors could be effective against multiple poxviruses.

Návaznosti

90242, velká výzkumná infrastruktura

Název: CIISB III

Citovat

DUCHOSLAV, Vojtech a Evzen BOURA. Structure of monkeypox virus poxin: implications for drug design. Archives of Virology. Wien: SPRINGER WIEN, 2023, roč. 168, č. 7, s. 1-5. ISSN 0304-8608. Dostupné z: https://doi.org/10.1007/s00705-023-05824-4.

@article{2487202,
   author = {Duchoslav, Vojtech and Boura, Evzen},
   article_location = {Wien},
   article_number = {7},
   doi = {https://doi.org/10.1007/s00705-023-05824-4},
   keywords = {LENACAPAVIR; crystal structure; mpox poxin; binding site; inhibitors},
   language = {eng},
   issn = {0304-8608},
   journal = {Archives of Virology},
   title = {Structure of monkeypox virus poxin: implications for drug design},
   url = {https://link.springer.com/article/10.1007/s00705-023-05824-4},
   volume = {168},
   year = {2023}
}

TY  - JOUR
ID  - 2487202
AU  - Duchoslav, Vojtech - Boura, Evzen
PY  - 2023
TI  - Structure of monkeypox virus poxin: implications for drug design
JF  - Archives of Virology
VL  - 168
IS  - 7
SP  - 1-5
EP  - 1-5
PB  - SPRINGER WIEN
SN  - 03048608
KW  - LENACAPAVIR
KW  - crystal structure
KW  - mpox poxin
KW  - binding site
KW  - inhibitors
UR  - https://link.springer.com/article/10.1007/s00705-023-05824-4
N2  - Monkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine (JYNNEOS) and an effective drug (tecovirimat), concerns remain over the possible recurrence of a viral pandemic. Like any other virus, mpox virus must overcome the immune system to replicate. Viruses have evolved various strategies to overcome both innate and adaptive immunity. Poxviruses possess an unusual nuclease, poxin, which cleaves 2'-3'-cGAMP, a cyclic dinucleotide, which is an important second messenger in the cGAS-STING signaling pathway. Here, we present the crystal structure of mpox poxin. The structure reveals a conserved, predominantly ss- sheet fold and highlights the high conservation of the cGAMP binding site and of the catalytic residues His17, Tyr138, and Lys142. This research suggests that poxin inhibitors could be effective against multiple poxviruses.
ER  -

DUCHOSLAV, Vojtech a Evzen BOURA. Structure of monkeypox virus poxin: implications for drug design. \textit{Archives of Virology}. Wien: SPRINGER WIEN, 2023, roč.~168, č.~7, s.~1-5. ISSN~0304-8608. Dostupné z: https://doi.org/10.1007/s00705-023-05824-4.

Přehled o publikaci