Anti-Cancer Potential of a new Derivative of Caffeic Acid
Phenethyl Ester targeting the Centrosome

J 2025

Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

GIORDANO, Catello; Jonatan KENDLER; Maximilian SEXL; Sebastian KOLLMAN; Maxim VARENICJA et al.

Základní údaje

Originální název

Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

Autoři

Vydání

Redox Biology, Amsterdam, Elsevier, 2025, 2213-2317

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 11.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140919

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Centrosome; Caffeic Acid Phenethyl Ester

Štítky

14110323, CF BIOIT, CF GEN, CF PROT, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 3. 2026 13:31, Mgr. Tereza Miškechová

Anotace

V originále

Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal gamma-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies.

Návaznosti

EH23_015/0008175, projekt VaV

Název: Inovace České infrastruktury pro integrativní strukturní biologii

90242, velká výzkumná infrastruktura

Název: CIISB III

90254, velká výzkumná infrastruktura

Název: e-INFRA CZ II

90267, velká výzkumná infrastruktura

Název: NCMG III

Citovat

GIORDANO, Catello; Jonatan KENDLER; Maximilian SEXL; Sebastian KOLLMAN; Maxim VARENICJA; Boglarka SZABO; Gerald TIMELTHALER; Dominik KIRCHHOFER; Oldamur HOLLOCZKI; Suzanne Dawn TURNER; Richard MORIGGL; Lukas KENNER; Mohamed TOUAIBIA a Olaf MERKEL. Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome. Redox Biology. Amsterdam: Elsevier, 2025, roč. 81, April 2025, s. 1-11. ISSN 2213-2317. Dostupné z: https://doi.org/10.1016/j.redox.2025.103582.

@article{2488480,
   author = {Giordano, Catello and Kendler, Jonatan and Sexl, Maximilian and Kollman, Sebastian and Varenicja, Maxim and Szabo, Boglarka and Timelthaler, Gerald and Kirchhofer, Dominik and Holloczki, Oldamur and Turner, Suzanne Dawn and Moriggl, Richard and Kenner, Lukas and Touaibia, Mohamed and Merkel, Olaf},
   article_location = {Amsterdam},
   article_number = {April 2025},
   doi = {https://doi.org/10.1016/j.redox.2025.103582},
   keywords = {Centrosome; Caffeic Acid Phenethyl Ester},
   language = {eng},
   issn = {2213-2317},
   journal = {Redox Biology},
   title = {Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome},
   url = {https://www.sciencedirect.com/science/article/pii/S2213231725000953?via%3Dihub},
   volume = {81},
   year = {2025}
}

TY  - JOUR
ID  - 2488480
AU  - Giordano, Catello - Kendler, Jonatan - Sexl, Maximilian - Kollman, Sebastian - Varenicja, Maxim - Szabo, Boglarka - Timelthaler, Gerald - Kirchhofer, Dominik - Holloczki, Oldamur - Turner, Suzanne Dawn - Moriggl, Richard - Kenner, Lukas - Touaibia, Mohamed - Merkel, Olaf
PY  - 2025
TI  - Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome
JF  - Redox Biology
VL  - 81
IS  - April 2025
SP  - 1-11
EP  - 1-11
PB  - Elsevier
SN  - 22132317
KW  - Centrosome
KW  - Caffeic Acid Phenethyl Ester
UR  - https://www.sciencedirect.com/science/article/pii/S2213231725000953?via%3Dihub
N2  - Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal gamma-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies.
ER  -

GIORDANO, Catello; Jonatan KENDLER; Maximilian SEXL; Sebastian KOLLMAN; Maxim VARENICJA; Boglarka SZABO; Gerald TIMELTHALER; Dominik KIRCHHOFER; Oldamur HOLLOCZKI; Suzanne Dawn TURNER; Richard MORIGGL; Lukas KENNER; Mohamed TOUAIBIA a Olaf MERKEL. Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome. \textit{Redox Biology}. Amsterdam: Elsevier, 2025, roč.~81, April 2025, s.~1-11. ISSN~2213-2317. Dostupné z: https://doi.org/10.1016/j.redox.2025.103582.

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