Computational modeling of bone allograft reconstruction
following femoral shaft tumor resection: Investigating the
impact of supplementary plate fixation

J 2025

Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

BOHAC, Petr; Vasileios APOSTOLOPOULOS; Petr MARCIAN; Tomáš TOMÁŠ; Michal MAHDAL et al.

Základní údaje

Originální název

Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Autoři

BOHAC, Petr; Vasileios APOSTOLOPOULOS; Petr MARCIAN; Tomáš TOMÁŠ; Michal MAHDAL a Tomas NAVRAT

Vydání

Plos one, San Francisco, Public Library of Science, 2025, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30211 Orthopaedics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

bone allograft reconstruction; femoral shaft tumor resection; computational modeling

Štítky

14110123, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 4. 2025 10:39, Mgr. Tereza Miškechová

Anotace

V originále

Background and objective The use of bone allograft reconstructions after tumor resection can introduce significant complications. Stable fixation is required to decrease the incidence of mechanical complications of segmental bone allografts. The purpose of the present study is to compare plating fixation methods of diaphyseal allografts after intercalary resection of the femur. Methods We created four defined fixation models using plates and/or intramedullary polymethylmethacrylate (PMMA) to simulate typical bone tumor resection with intercalary allograft reconstruction. One angularly stable plate (DFP) with 13 locking screws and fresh frozen allografts (labeled “I”) were used for bone reconstruction. Three modified reconstructions were created: “II” included a supplementary plate (SP) with four locking screws, “III” was augmented with intramedullary PMMA in the allograft, and “IV” combined intramedullary PMMA and both plates. We applied a load model that simulates partial weight bearing on the lower limb to simulate the load during postoperative rehabilitation. Results The highest stress in the DFP occurred at the allograft-bone transition, with variant IV reaching 297 MPa. PMMA augmentation reduced median interfragmentary motion (IFM) and sliding distances, with variant III achieving the lowest distal sliding distance (0.9 μm) in the distal area. Supplementary plate fixation reduced maximal and median proximal IFM distances (86.9 μm in variant II vs. 116.0 μm in variant I) but increased sliding distances (23.7 μm in variant II vs. 0.6 μm in variant I). Conclusions PMMA augmentation reduces IFM and sliding distances, enhancing rigidity, particularly in the distal area. Supplementary plate fixation decreases IFM distances in the proximal area but increases sliding distances in the same region. Variants III and IV demonstrate lower IFM and sliding distances in the distal area overall. Variant III shows very low sliding distances in both distal and proximal areas. Variant IV combines improved firmness with slightly higher stress levels.

Citovat

BOHAC, Petr; Vasileios APOSTOLOPOULOS; Petr MARCIAN; Tomáš TOMÁŠ; Michal MAHDAL a Tomas NAVRAT. Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation. Plos one. San Francisco: Public Library of Science, 2025, roč. 20, č. 2, s. 1-20. ISSN 1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0316719.

@article{2488677,
   author = {Bohac, Petr and Apostolopoulos, Vasileios and Marcian, Petr and Tomáš, Tomáš and Mahdal, Michal and Navrat, Tomas},
   article_location = {San Francisco},
   article_number = {2},
   doi = {https://doi.org/10.1371/journal.pone.0316719},
   keywords = {bone allograft reconstruction; femoral shaft tumor resection; computational modeling},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719},
   volume = {20},
   year = {2025}
}

TY  - JOUR
ID  - 2488677
AU  - Bohac, Petr - Apostolopoulos, Vasileios - Marcian, Petr - Tomáš, Tomáš - Mahdal, Michal - Navrat, Tomas
PY  - 2025
TI  - Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation
JF  - Plos one
VL  - 20
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - Public Library of Science
SN  - 19326203
KW  - bone allograft reconstruction
KW  - femoral shaft tumor resection
KW  - computational modeling
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719
N2  - Background and objective The use of bone allograft reconstructions after tumor resection can introduce significant complications. Stable fixation is required to decrease the incidence of mechanical complications of segmental bone allografts. The purpose of the present study is to compare plating fixation methods of diaphyseal allografts after intercalary resection of the femur. Methods We created four defined fixation models using plates and/or intramedullary polymethylmethacrylate (PMMA) to simulate typical bone tumor resection with intercalary allograft reconstruction. One angularly stable plate (DFP) with 13 locking screws and fresh frozen allografts (labeled “I”) were used for bone reconstruction. Three modified reconstructions were created: “II” included a supplementary plate (SP) with four locking screws, “III” was augmented with intramedullary PMMA in the allograft, and “IV” combined intramedullary PMMA and both plates. We applied a load model that simulates partial weight bearing on the lower limb to simulate the load during postoperative rehabilitation. Results The highest stress in the DFP occurred at the allograft-bone transition, with variant IV reaching 297 MPa. PMMA augmentation reduced median interfragmentary motion (IFM) and sliding distances, with variant III achieving the lowest distal sliding distance (0.9 μm) in the distal area. Supplementary plate fixation reduced maximal and median proximal IFM distances (86.9 μm in variant II vs. 116.0 μm in variant I) but increased sliding distances (23.7 μm in variant II vs. 0.6 μm in variant I). Conclusions PMMA augmentation reduces IFM and sliding distances, enhancing rigidity, particularly in the distal area. Supplementary plate fixation decreases IFM distances in the proximal area but increases sliding distances in the same region. Variants III and IV demonstrate lower IFM and sliding distances in the distal area overall. Variant III shows very low sliding distances in both distal and proximal areas. Variant IV combines improved firmness with slightly higher stress levels.
ER  -

BOHAC, Petr; Vasileios APOSTOLOPOULOS; Petr MARCIAN; Tomáš TOMÁŠ; Michal MAHDAL a Tomas NAVRAT. Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation. \textit{Plos one}. San Francisco: Public Library of Science, 2025, roč.~20, č.~2, s.~1-20. ISSN~1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0316719.

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