Development of 3D-Printed Chewable Gummy Tablets with
Adjustable Ondansetron Content for the Treatment of Pediatric
Patients

J 2025

Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients

VESELÝ, Martin; David ZÁRUBA a Jan ELBL

Základní údaje

Originální název

Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients

Autoři

VESELÝ, Martin (203 Česká republika, garant, domácí); David ZÁRUBA (203 Česká republika, domácí) a Jan ELBL (203 Česká republika, domácí)

Vydání

PHARMACEUTICS, SWITZERLAND, MDPI, 2025, 1999-4923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.900 v roce 2023

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/pharmaceutics17040458

UT WoS

001474517500001

EID Scopus

2-s2.0-105003545117

Klíčová slova anglicky

3D print; SSE; individualized therapy; gummy formulation; ondansetron

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 5. 2025 14:36, Ing. Richard Heger, Ph.D.

Anotace

V originále

Background/Objectives: Semi-solid extrusion (SSE) 3D printing is an innovative method utilized for preparation of various drug dosage forms, allowing for individualization by means of incorporation of one or multiple drugs in adjustable doses. SSE provides repeatable results and can be conveniently utilized in small batch production. This study aimed to develop a chewable formulation for pediatric patients which could be easily printed using SSE. Methods: Pectin and gelatin were utilized as gel-forming agents, polyvinylpyrrolidone as a thickener, glycerol as a plasticizer, citric acid as a pH modifier, and potassium sorbate as a conserving agent. Obtained tablets were evaluated for mass and content homogeneity and their mechanical properties compared to the long-time market standard for gummies. Results: Gummy formulation with texture properties comparable to the selected standard and mass homogeneity were prepared. The linear correlation between the model size and ondansetron content was proven. Conclusions: SSE 3D printing thus presents a suitable method of gummy formulation production with possible adjustment of dose by defining the object size.

Návaznosti

MUNI/A/1157/2022, interní kód MU

Název: Optimalizace formulace a přípravy 3D tištěné personalizované lékové formy pro pediatrické pacienty

Investor: Masarykova univerzita, Optimalizace formulace a přípravy 3D tištěné personalizované lékové formy pro pediatrické pacienty

Citovat

VESELÝ, Martin; David ZÁRUBA a Jan ELBL. Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients. PHARMACEUTICS. SWITZERLAND: MDPI, 2025, roč. 17, č. 4, s. 1-20. ISSN 1999-4923. Dostupné z: https://dx.doi.org/10.3390/pharmaceutics17040458.

@article{2489621,
   author = {Veselý, Martin and Záruba, David and Elbl, Jan},
   article_location = {SWITZERLAND},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/pharmaceutics17040458},
   keywords = {3D print; SSE; individualized therapy; gummy formulation; ondansetron},
   language = {eng},
   issn = {1999-4923},
   journal = {PHARMACEUTICS},
   title = {Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients},
   url = {https://www.mdpi.com/1999-4923/17/4/458},
   volume = {17},
   year = {2025}
}

TY  - JOUR
ID  - 2489621
AU  - Veselý, Martin - Záruba, David - Elbl, Jan
PY  - 2025
TI  - Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients
JF  - PHARMACEUTICS
VL  - 17
IS  - 4
SP  - 1-20
EP  - 1-20
PB  - MDPI
SN  - 19994923
KW  - 3D print
KW  - SSE
KW  - individualized therapy
KW  - gummy formulation
KW  - ondansetron
UR  - https://www.mdpi.com/1999-4923/17/4/458
N2  - Background/Objectives: Semi-solid extrusion (SSE) 3D printing is an innovative method utilized for preparation of various drug dosage forms, allowing for individualization by means of incorporation of one or multiple drugs in adjustable doses. SSE provides repeatable results and can be conveniently utilized in small batch production. This study aimed to develop a chewable formulation for pediatric patients which could be easily printed using SSE. Methods: Pectin and gelatin were utilized as gel-forming agents, polyvinylpyrrolidone as a thickener, glycerol as a plasticizer, citric acid as a pH modifier, and potassium sorbate as a conserving agent. Obtained tablets were evaluated for mass and content homogeneity and their mechanical properties compared to the long-time market standard for gummies. Results: Gummy formulation with texture properties comparable to the selected standard and mass homogeneity were prepared. The linear correlation between the model size and ondansetron content was proven. Conclusions: SSE 3D printing thus presents a suitable method of gummy formulation production with possible adjustment of dose by defining the object size.
ER  -

VESELÝ, Martin; David ZÁRUBA a Jan ELBL. Development of 3D-Printed Chewable Gummy Tablets with Adjustable Ondansetron Content for the Treatment of Pediatric Patients. \textit{PHARMACEUTICS}. SWITZERLAND: MDPI, 2025, roč.~17, č.~4, s.~1-20. ISSN~1999-4923. Dostupné z: https://dx.doi.org/10.3390/pharmaceutics17040458.

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