Atrial fibrillation’s role in MitraClip patient outcomes: a
retrospective analysis of mortality and heart failure
hospitalization in a single-centre cohort

J 2026

Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort

CESNAKOVA KONECNA, Alica; Otakar JIRAVSKÝ; Jan Alexander MOHR; Miroslav HUDEC; Jaroslav JANUSKA et al.

Základní údaje

Originální název

Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort

Autoři

Vydání

HELLENIC JOURNAL OF CARDIOLOGY, AMSTERDAM, ELSEVIER, 2026, 1109-9666

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Mitral regurgitation; MitraClip; Transcatheter mitral valve repair; Atrial fibrillation; Heart failure; Mortality

Štítky

14110515

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 2. 2026 09:13, Mgr. Tereza Miškechová

Anotace

V originále

Objective Atrial fibrillation (AF) is common in patients with mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) with MitraClip; however, its impact on procedural hemodynamics and clinical outcomes remains inadequately characterized. Methods This retrospective single-center study analyzed 226 high-risk patients who underwent MitraClip implantation between 2010 and 2022. The primary endpoint was time to first heart failure hospitalization. Secondary endpoints included procedural hemodynamics and long-term mortality. Results AF was observed in 46.9% of the patients and was associated with distinct hemodynamic features, including significantly elevated right (11 vs. 9 mmHg, P = 0.008) and left atrial pressures (17 vs. 15 mmHg, P = 0.023). Despite similar procedural success rates, patients with AF experienced markedly accelerated time to first HF hospitalization (median 48 vs. 106 weeks, P = 0.005). Tricuspid regurgitation at discharge emerged as the strongest predictor of early heart failure hospitalization (HR 1.393, 95% CI: 1.009–1.924, P = 0.044). One-year mortality (16.0% vs. 16.7%, P = 0.899) and long-term survival remained comparable between groups. Conclusion AF in TEER patients is characterized by elevated atrial filling pressures and substantially accelerated time to heart failure hospitalization, with tricuspid regurgitation at discharge predicting early events. Although these findings indicate the need for more intensive monitoring of patients with AF during the first post-procedural year, comparable survival rates suggest that AF alone should not preclude TEER in otherwise suitable candidates.

Citovat

CESNAKOVA KONECNA, Alica; Otakar JIRAVSKÝ; Jan Alexander MOHR; Miroslav HUDEC; Jaroslav JANUSKA; Ivan RANIC; Radim SPACEK; Piotr BRANNY; David VICIAN; Bogna JIRAVSKA GODULA; Libor SKNOURIL; Leos PLEVA a Matej PEKAŘ. Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort. HELLENIC JOURNAL OF CARDIOLOGY. AMSTERDAM: ELSEVIER, 2026. ISSN 1109-9666. Dostupné z: https://doi.org/10.1016/j.hjc.2025.03.004.

@article{2492298,
   author = {Cesnakova Konecna, Alica and Jiravský, Otakar and Mohr, Jan Alexander and Hudec, Miroslav and Januska, Jaroslav and Ranic, Ivan and Spacek, Radim and Branny, Piotr and Vician, David and Jiravska Godula, Bogna and Sknouril, Libor and Pleva, Leos and Pekař, Matej},
   article_location = {AMSTERDAM},
   doi = {https://doi.org/10.1016/j.hjc.2025.03.004},
   keywords = {Mitral regurgitation; MitraClip; Transcatheter mitral valve repair; Atrial fibrillation; Heart failure; Mortality},
   language = {eng},
   issn = {1109-9666},
   journal = {HELLENIC JOURNAL OF CARDIOLOGY},
   title = {Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort},
   url = {https://www.sciencedirect.com/science/article/pii/S1109966625000764},
   year = {2026}
}

TY  - JOUR
ID  - 2492298
AU  - Cesnakova Konecna, Alica - Jiravský, Otakar - Mohr, Jan Alexander - Hudec, Miroslav - Januska, Jaroslav - Ranic, Ivan - Spacek, Radim - Branny, Piotr - Vician, David - Jiravska Godula, Bogna - Sknouril, Libor - Pleva, Leos - Pekař, Matej
PY  - 2026
TI  - Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort
JF  - HELLENIC JOURNAL OF CARDIOLOGY
PB  - ELSEVIER
SN  - 11099666
KW  - Mitral regurgitation
KW  - MitraClip
KW  - Transcatheter mitral valve repair
KW  - Atrial fibrillation
KW  - Heart failure
KW  - Mortality
UR  - https://www.sciencedirect.com/science/article/pii/S1109966625000764
N2  - Objective Atrial fibrillation (AF) is common in patients with mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) with MitraClip; however, its impact on procedural hemodynamics and clinical outcomes remains inadequately characterized. Methods This retrospective single-center study analyzed 226 high-risk patients who underwent MitraClip implantation between 2010 and 2022. The primary endpoint was time to first heart failure hospitalization. Secondary endpoints included procedural hemodynamics and long-term mortality. Results AF was observed in 46.9% of the patients and was associated with distinct hemodynamic features, including significantly elevated right (11 vs. 9 mmHg, P = 0.008) and left atrial pressures (17 vs. 15 mmHg, P = 0.023). Despite similar procedural success rates, patients with AF experienced markedly accelerated time to first HF hospitalization (median 48 vs. 106 weeks, P = 0.005). Tricuspid regurgitation at discharge emerged as the strongest predictor of early heart failure hospitalization (HR 1.393, 95% CI: 1.009–1.924, P = 0.044). One-year mortality (16.0% vs. 16.7%, P = 0.899) and long-term survival remained comparable between groups. Conclusion AF in TEER patients is characterized by elevated atrial filling pressures and substantially accelerated time to heart failure hospitalization, with tricuspid regurgitation at discharge predicting early events. Although these findings indicate the need for more intensive monitoring of patients with AF during the first post-procedural year, comparable survival rates suggest that AF alone should not preclude TEER in otherwise suitable candidates.
ER  -

CESNAKOVA KONECNA, Alica; Otakar JIRAVSKÝ; Jan Alexander MOHR; Miroslav HUDEC; Jaroslav JANUSKA; Ivan RANIC; Radim SPACEK; Piotr BRANNY; David VICIAN; Bogna JIRAVSKA GODULA; Libor SKNOURIL; Leos PLEVA a Matej PEKAŘ. Atrial fibrillation’s role in MitraClip patient outcomes: a retrospective analysis of mortality and heart failure hospitalization in a single-centre cohort. \textit{HELLENIC JOURNAL OF CARDIOLOGY}. AMSTERDAM: ELSEVIER, 2026. ISSN~1109-9666. Dostupné z: https://doi.org/10.1016/j.hjc.2025.03.004.

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