CT-derived adipose tissue characteristics and TAVI all-cause
mortality and complications: a systematic review

J 2025

CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review

PEKAŘ, Matej; Piotr BRANNY; Otakar JIRAVSKÝ; Radim SPACEK; Jan Alexander MOHR et al.

Základní údaje

Originální název

CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review

Autoři

Vydání

European Journal of Medical Research, London, BMC, 2025, 0949-2321

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.400 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

TAVI outcomes; Adipose tissue parameters; CT-derived body composition; Visceral fat; Subcutaneous fat; Risk stratification

Štítky

14110211, 14110515

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2026 12:58, Mgr. Tereza Miškechová

Anotace

V originále

Transcatheter Aortic Valve Implantation (TAVI) has revolutionized severe aortic stenosis treatment, but risk stratification remains challenging. This systematic review examined the association between computed tomography (CT)-derived adipose tissue parameters and TAVI outcomes. We searched major databases for studies on visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissue parameters and post-TAVI outcomes. Fourteen studies (9692 patients) were included. Higher SAT area/volume was consistently associated with better survival (5 studies, HR range: 0.83-2.77, p < 0.05). Lower SAT and VAT density also correlated with better survival (5 and 4 studies, respectively, HR range: 1.31-1.46, p < 0.05). VAT area showed mixed results. A VAT:SAT ratio < 1 was associated with better cardiovascular outcomes in one study. Lower IMAT index correlated with shorter hospital stays in a single study. This review reveals complex relationships between adipose tissue parameters and TAVI outcomes. Lower adipose tissue density and higher subcutaneous adiposity were most consistently associated with better outcomes. These findings suggest that detailed analysis of adipose tissue characteristics may enhance risk stratification in TAVI candidates.

Citovat

PEKAŘ, Matej; Piotr BRANNY; Otakar JIRAVSKÝ; Radim SPACEK; Jan Alexander MOHR; Ivan RANIC; Bogna JIRAVSKA GODULA; Alica CESNAKOVA KONECNA; Marek KANTOR; Jan HECKO; Radek NEUWIRTH; Libor SKNOURIL a Jan NOVÁK. CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review. European Journal of Medical Research. London: BMC, 2025, roč. 30, č. 1, s. 1-13. ISSN 0949-2321. Dostupné z: https://doi.org/10.1186/s40001-025-02587-3.

@article{2493217,
   author = {Pekař, Matej and Branny, Piotr and Jiravský, Otakar and Spacek, Radim and Mohr, Jan Alexander and Ranic, Ivan and Jiravska Godula, Bogna and Cesnakova Konecna, Alica and Kantor, Marek and Hecko, Jan and Neuwirth, Radek and Sknouril, Libor and Novák, Jan},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1186/s40001-025-02587-3},
   keywords = {TAVI outcomes; Adipose tissue parameters; CT-derived body composition; Visceral fat; Subcutaneous fat; Risk stratification},
   language = {eng},
   issn = {0949-2321},
   journal = {European Journal of Medical Research},
   title = {CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review},
   url = {https://link.springer.com/article/10.1186/s40001-025-02587-3},
   volume = {30},
   year = {2025}
}

TY  - JOUR
ID  - 2493217
AU  - Pekař, Matej - Branny, Piotr - Jiravský, Otakar - Spacek, Radim - Mohr, Jan Alexander - Ranic, Ivan - Jiravska Godula, Bogna - Cesnakova Konecna, Alica - Kantor, Marek - Hecko, Jan - Neuwirth, Radek - Sknouril, Libor - Novák, Jan
PY  - 2025
TI  - CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review
JF  - European Journal of Medical Research
VL  - 30
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - BMC
SN  - 09492321
KW  - TAVI outcomes
KW  - Adipose tissue parameters
KW  - CT-derived body composition
KW  - Visceral fat
KW  - Subcutaneous fat
KW  - Risk stratification
UR  - https://link.springer.com/article/10.1186/s40001-025-02587-3
N2  - Transcatheter Aortic Valve Implantation (TAVI) has revolutionized severe aortic stenosis treatment, but risk stratification remains challenging. This systematic review examined the association between computed tomography (CT)-derived adipose tissue parameters and TAVI outcomes. We searched major databases for studies on visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissue parameters and post-TAVI outcomes. Fourteen studies (9692 patients) were included. Higher SAT area/volume was consistently associated with better survival (5 studies, HR range: 0.83-2.77, p < 0.05). Lower SAT and VAT density also correlated with better survival (5 and 4 studies, respectively, HR range: 1.31-1.46, p < 0.05). VAT area showed mixed results. A VAT:SAT ratio < 1 was associated with better cardiovascular outcomes in one study. Lower IMAT index correlated with shorter hospital stays in a single study. This review reveals complex relationships between adipose tissue parameters and TAVI outcomes. Lower adipose tissue density and higher subcutaneous adiposity were most consistently associated with better outcomes. These findings suggest that detailed analysis of adipose tissue characteristics may enhance risk stratification in TAVI candidates.
ER  -

PEKAŘ, Matej; Piotr BRANNY; Otakar JIRAVSKÝ; Radim SPACEK; Jan Alexander MOHR; Ivan RANIC; Bogna JIRAVSKA GODULA; Alica CESNAKOVA KONECNA; Marek KANTOR; Jan HECKO; Radek NEUWIRTH; Libor SKNOURIL a Jan NOVÁK. CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review. \textit{European Journal of Medical Research}. London: BMC, 2025, roč.~30, č.~1, s.~1-13. ISSN~0949-2321. Dostupné z: https://doi.org/10.1186/s40001-025-02587-3.

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