Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration
in Open‑Heart Surgery Patients Receiving Negative Pressure
Wound Therapy for Deep Sternal Wound Infection: A Single‑Center
Prospective Observational Study

J 2025

Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study

ĎURICOVÁ, Jana; Hana BROZMANOVÁ; Jan JUŘICA; Ivana KACÍŘOVÁ; Pavel ŠIŠTÍK et al.

Základní údaje

Originální název

Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study

Autoři

ĎURICOVÁ, Jana; Hana BROZMANOVÁ; Jan JUŘICA; Ivana KACÍŘOVÁ; Pavel ŠIŠTÍK; Klára KAŇKOVÁ; Hana TOMÁŠKOVÁ a Martin KOLEK

Vydání

Bratislava Medical Journal, LONDON, SPRINGERNATURE, 2025, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.100 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00141263

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Ciprofloxacin; Clindamycin; Co-trimoxazole; Deep sternal wound infection; Negative pressure wound therapy; Wound penetration

Štítky

14110516, rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 3. 2026 14:28, Mgr. Tereza Miškechová

Anotace

V originále

Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 ± 1.43) than for total clindamycin concentrations (0.83 ± 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 ± 0.35 vs. 0.81 ± 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 ± 20 days) than in those without infection (14 ± 12 days; p < 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.

Citovat

ĎURICOVÁ, Jana; Hana BROZMANOVÁ; Jan JUŘICA; Ivana KACÍŘOVÁ; Pavel ŠIŠTÍK; Klára KAŇKOVÁ; Hana TOMÁŠKOVÁ a Martin KOLEK. Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study. Bratislava Medical Journal. LONDON: SPRINGERNATURE, 2025, roč. 126, č. 8, s. 1891-1903. ISSN 0006-9248. Dostupné z: https://doi.org/10.1007/s44411-025-00194-6.

@article{2499759,
   author = {Ďuricová, Jana and Brozmanová, Hana and Juřica, Jan and Kacířová, Ivana and Šištík, Pavel and Kaňková, Klára and Tomášková, Hana and Kolek, Martin},
   article_location = {LONDON},
   article_number = {8},
   doi = {https://doi.org/10.1007/s44411-025-00194-6},
   keywords = {Ciprofloxacin; Clindamycin; Co-trimoxazole; Deep sternal wound infection; Negative pressure wound therapy; Wound penetration},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal},
   title = {Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study},
   url = {https://link.springer.com/article/10.1007/s44411-025-00194-6},
   volume = {126},
   year = {2025}
}

TY  - JOUR
ID  - 2499759
AU  - Ďuricová, Jana - Brozmanová, Hana - Juřica, Jan - Kacířová, Ivana - Šištík, Pavel - Kaňková, Klára - Tomášková, Hana - Kolek, Martin
PY  - 2025
TI  - Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study
JF  - Bratislava Medical Journal
VL  - 126
IS  - 8
SP  - 1891-1903
EP  - 1891-1903
PB  - SPRINGERNATURE
SN  - 00069248
KW  - Ciprofloxacin
KW  - Clindamycin
KW  - Co-trimoxazole
KW  - Deep sternal wound infection
KW  - Negative pressure wound therapy
KW  - Wound penetration
UR  - https://link.springer.com/article/10.1007/s44411-025-00194-6
N2  - Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 ± 1.43) than for total clindamycin concentrations (0.83 ± 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 ± 0.35 vs. 0.81 ± 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 ± 20 days) than in those without infection (14 ± 12 days; p < 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.
ER  -

ĎURICOVÁ, Jana; Hana BROZMANOVÁ; Jan JUŘICA; Ivana KACÍŘOVÁ; Pavel ŠIŠTÍK; Klára KAŇKOVÁ; Hana TOMÁŠKOVÁ a Martin KOLEK. Clindamycin, Ciprofoxacin, and Co‑trimoxazole Wound Penetration in Open‑Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single‑Center Prospective Observational Study. \textit{Bratislava Medical Journal}. LONDON: SPRINGERNATURE, 2025, roč.~126, č.~8, s.~1891-1903. ISSN~0006-9248. Dostupné z: https://doi.org/10.1007/s44411-025-00194-6.

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