A Systematic Review of Current Terminology for Conditions
Preceding Degenerative Cervical Myelopathy: Evidence Synthesis
to Inform an AO Spine Expert Opinion Statement

J 2025

A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement

AGRAWAL, Vinisha; Mohammed Farhan ALI; Froher YASIN; Daniyal ASHRAF; Jamie F M BRANNIGAN et al.

Základní údaje

Originální název

A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement

Autoři

Vydání

GLOBAL SPINE JOURNAL, LONDON, SAGE PUBLICATIONS LTD, 2025, 2192-5682

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00144728

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

cervical myelopathy; spinal cord compression; ossification of the posterior longitudinal ligament; spondylosis; disc herniation; cervical stenosis; spinal stenosis

Štítky

14110221, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 11. 2025 13:11, Mgr. Tereza Miškechová

Anotace

V originále

Study Design: Systematic review. Objectives: The pre-symptomatic state of Degenerative Cervical Myelopathy (DCM), wherein degenerative changes and spinal cord compression are seen without clinical findings, is poorly understood and inconsistently categorised. Clear identification may elucidate the temporality of DCM development. Therefore, a systematic assessment was undertaken of current terminology for pre-DCM states, with the objective of standardising definitions and informing an AO Spine expert position statement. Methods: Medline and Embase were searched for all studies on asymptomatic spinal compression or clinical findings preceding DCM, returning 3585 studies. After screening, 96 studies were included in the final analysis. The terminology used for pre-DCM states and their definitions were extracted, along with their frequencies or speciality/country of author in the literature. Results Multiple terms were used to represent pre-DCM stages, including "asymptomatic" (86 studies), "non-myelopathic" (26 studies), "without myelopathy" (15 studies), "pre-symptomatic" (9 studies) and "sub-clinical" (7 studies). "asymptomatic" was associated with the greatest inconsistency. Some defined this as patients with radiological signs of spinal degeneration with/without spinal cord compression but no clinical signs of myelopathy, whereas others used the term synonymously with healthy controls. This inconsistency is particularly challenging in clinical studies in which DCM patients are compared to those with pre-DCM states and/or healthy volunteers. Conclusion: There is substantial inconsistency in the terms used to describe pre-DCM states. There is no clear relationship between the terms used and the country or speciality of the main author. Standardised definitions for these disease states should be agreed and used in future studies.

Návaznosti

NU22-04-00024, projekt VaV

Název: Kvantitativní zobrazovací MR parametry jako prediktory průběhu nemyelopatické degenerativní komprese krční míchy: longitudinální studie

Investor: Ministerstvo zdravotnictví ČR, Kvantitativní zobrazovací MR parametry jako prediktory průběhu nemyelopatické degenerativní komprese krční míchy: longitudinální studie, Podprogram 1 - standardní

Citovat

AGRAWAL, Vinisha; Mohammed Farhan ALI; Froher YASIN; Daniyal ASHRAF; Jamie F M BRANNIGAN; Ratko YURAC; Vishal KUMAR; Rory MURPHY; Enrico TESSITORE; Granit MOLLIQAJ; Joost DEJAEGHER; Juan Jose ZAMORANO; Guy WYNNE-JONES; Manjul TRIPATHI; David B ANDERSON; Jose Joefrey F ARBATIN; So KATO; Ronie Romelean JAYAPALAN; Nicolas DEA; James S HARROP; Jefferson WILSON; Brian K KWON; Allan R MARTIN; Josef BEDNAŘÍK; Mark R KOTTER; Benjamin M DAVIES; Oliver D MOWFORTH a Aria NOURI. A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement. GLOBAL SPINE JOURNAL. LONDON: SAGE PUBLICATIONS LTD, 2025, roč. 15, č. 7, s. 3506-3516. ISSN 2192-5682. Dostupné z: https://doi.org/10.1177/21925682251339480.

@article{2500986,
   author = {Agrawal, Vinisha and Ali, Mohammed Farhan and Yasin, Froher and Ashraf, Daniyal and Brannigan, Jamie F M and Yurac, Ratko and Kumar, Vishal and Murphy, Rory and Tessitore, Enrico and Molliqaj, Granit and Dejaegher, Joost and Zamorano, Juan Jose and WynneandJones, Guy and Tripathi, Manjul and Anderson, David B and Arbatin, Jose Joefrey F and Kato, So and Jayapalan, Ronie Romelean and Dea, Nicolas and Harrop, James S and Wilson, Jefferson and Kwon, Brian K and Martin, Allan R and Bednařík, Josef and Kotter, Mark R and Davies, Benjamin M and Mowforth, Oliver D and Nouri, Aria},
   article_location = {LONDON},
   article_number = {7},
   doi = {https://doi.org/10.1177/21925682251339480},
   keywords = {cervical myelopathy; spinal cord compression; ossification of the posterior longitudinal ligament; spondylosis; disc herniation; cervical stenosis; spinal stenosis},
   language = {eng},
   issn = {2192-5682},
   journal = {GLOBAL SPINE JOURNAL},
   title = {A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement},
   url = {https://journals.sagepub.com/doi/10.1177/21925682251339480},
   volume = {15},
   year = {2025}
}

TY  - JOUR
ID  - 2500986
AU  - Agrawal, Vinisha - Ali, Mohammed Farhan - Yasin, Froher - Ashraf, Daniyal - Brannigan, Jamie F M - Yurac, Ratko - Kumar, Vishal - Murphy, Rory - Tessitore, Enrico - Molliqaj, Granit - Dejaegher, Joost - Zamorano, Juan Jose - Wynne-Jones, Guy - Tripathi, Manjul - Anderson, David B - Arbatin, Jose Joefrey F - Kato, So - Jayapalan, Ronie Romelean - Dea, Nicolas - Harrop, James S - Wilson, Jefferson - Kwon, Brian K - Martin, Allan R - Bednařík, Josef - Kotter, Mark R - Davies, Benjamin M - Mowforth, Oliver D - Nouri, Aria
PY  - 2025
TI  - A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement
JF  - GLOBAL SPINE JOURNAL
VL  - 15
IS  - 7
SP  - 3506-3516
EP  - 3506-3516
PB  - SAGE PUBLICATIONS LTD
SN  - 21925682
KW  - cervical myelopathy
KW  - spinal cord compression
KW  - ossification of the posterior longitudinal ligament
KW  - spondylosis
KW  - disc herniation
KW  - cervical stenosis
KW  - spinal stenosis
UR  - https://journals.sagepub.com/doi/10.1177/21925682251339480
N2  - Study Design: Systematic review. Objectives: The pre-symptomatic state of Degenerative Cervical Myelopathy (DCM), wherein degenerative changes and spinal cord compression are seen without clinical findings, is poorly understood and inconsistently categorised. Clear identification may elucidate the temporality of DCM development. Therefore, a systematic assessment was undertaken of current terminology for pre-DCM states, with the objective of standardising definitions and informing an AO Spine expert position statement. Methods: Medline and Embase were searched for all studies on asymptomatic spinal compression or clinical findings preceding DCM, returning 3585 studies. After screening, 96 studies were included in the final analysis. The terminology used for pre-DCM states and their definitions were extracted, along with their frequencies or speciality/country of author in the literature. Results Multiple terms were used to represent pre-DCM stages, including "asymptomatic" (86 studies), "non-myelopathic" (26 studies), "without myelopathy" (15 studies), "pre-symptomatic" (9 studies) and "sub-clinical" (7 studies). "asymptomatic" was associated with the greatest inconsistency. Some defined this as patients with radiological signs of spinal degeneration with/without spinal cord compression but no clinical signs of myelopathy, whereas others used the term synonymously with healthy controls. This inconsistency is particularly challenging in clinical studies in which DCM patients are compared to those with pre-DCM states and/or healthy volunteers. Conclusion: There is substantial inconsistency in the terms used to describe pre-DCM states. There is no clear relationship between the terms used and the country or speciality of the main author. Standardised definitions for these disease states should be agreed and used in future studies.
ER  -

AGRAWAL, Vinisha; Mohammed Farhan ALI; Froher YASIN; Daniyal ASHRAF; Jamie F M BRANNIGAN; Ratko YURAC; Vishal KUMAR; Rory MURPHY; Enrico TESSITORE; Granit MOLLIQAJ; Joost DEJAEGHER; Juan Jose ZAMORANO; Guy WYNNE-JONES; Manjul TRIPATHI; David B ANDERSON; Jose Joefrey F ARBATIN; So KATO; Ronie Romelean JAYAPALAN; Nicolas DEA; James S HARROP; Jefferson WILSON; Brian K KWON; Allan R MARTIN; Josef BEDNAŘÍK; Mark R KOTTER; Benjamin M DAVIES; Oliver D MOWFORTH a Aria NOURI. A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement. \textit{GLOBAL SPINE JOURNAL}. LONDON: SAGE PUBLICATIONS LTD, 2025, roč.~15, č.~7, s.~3506-3516. ISSN~2192-5682. Dostupné z: https://doi.org/10.1177/21925682251339480.

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