Isolation of a unique monoterpene diperoxy dimer from Ziziphora
clinopodioides subsp. bungeana together with triterpenes with
antidiabetic properties

k 2025

Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties

MALANÍK, Milan; Jakub TREML; Renata KUBÍNOVÁ; Gabriela VÁVROVÁ; Michal ORAVEC et. al.

Základní údaje

Originální název

Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties

Autoři

MALANÍK, Milan; Jakub TREML; Renata KUBÍNOVÁ; Gabriela VÁVROVÁ; Michal ORAVEC; Jaromír MAREK ; Karlygash ZHAPARKULOVA a Karel ŠMEJKAL

Vydání

Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland, 2025

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

antidiabetic; GLUT4; pomolic acid; triterpenes; Ziziphora; α-glucosidase

Štítky

ÚChem Chem, ÚMF, ÚPL

Změněno: 27. 6. 2025 09:18, PharmDr. Milan Malaník, Ph.D.

Anotace

V originále

Extensive chromatographic separation of a chloroform-soluble fraction led to the isolation of twenty compounds, including a unique monoterpene diperoxy dimer (1). The structures were elucidated by 1D and 2D NMR experiments along with HRMS. Compound 1 was additionally identified by the single crystal X-ray diffraction method. α-Glucosidase inhibitory assay and GLUT4 expression and translocation in C2C12 myotubes were conducted to evaluate antidiabetic potential of selected compounds (1–11). Compounds 7 and 9–11 displayed more potent α-glucosidase inhibitory activity (IC50 45.3–135.3 µM) than acarbose used as a positive control (IC50 264.7 µM), while only pomolic acid (5) increased GLUT4 translocation in C2C12 myotubes in a significant manner.

Návaznosti

GA23-04655S, projekt VaV

Název: Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Investor: Grantová agentura ČR, Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Citovat

MALANÍK, Milan; Jakub TREML; Renata KUBÍNOVÁ; Gabriela VÁVROVÁ; Michal ORAVEC; Jaromír MAREK; Karlygash ZHAPARKULOVA a Karel ŠMEJKAL. Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties. In Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland. 2025.

@proceedings{2501962,
   author = {Malaník, Milan and Treml, Jakub and Kubínová, Renata and Vávrová, Gabriela and Oravec, Michal and Marek, Jaromír and Zhaparkulova, Karlygash and Šmejkal, Karel},
   booktitle = {Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland},
   keywords = {antidiabetic; GLUT4; pomolic acid; triterpenes; Ziziphora; α-glucosidase},
   language = {eng},
   title = {Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties},
   url = {https://konferencje.umw.edu.pl/psewroclaw2025/wp-content/uploads/sites/25/2025/06/the-Book-of-Abstracts_PSE-WRO-2025_15-6-2025.pdf},
   year = {2025}
}

TY  - CONF
ID  - 2501962
AU  - Malaník, Milan - Treml, Jakub - Kubínová, Renata - Vávrová, Gabriela - Oravec, Michal - Marek, Jaromír - Zhaparkulova, Karlygash - Šmejkal, Karel
PY  - 2025
TI  - Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties
KW  - antidiabetic
KW  - GLUT4
KW  - pomolic acid
KW  - triterpenes
KW  - Ziziphora
KW  - α-glucosidase
UR  - https://konferencje.umw.edu.pl/psewroclaw2025/wp-content/uploads/sites/25/2025/06/the-Book-of-Abstracts_PSE-WRO-2025_15-6-2025.pdf
N2  - Extensive chromatographic separation of a chloroform-soluble fraction led to the isolation of twenty compounds, including a unique monoterpene diperoxy dimer (1). The structures were elucidated by 1D and 2D NMR experiments along with HRMS. Compound 1 was additionally identified by the single crystal X-ray diffraction method. α-Glucosidase inhibitory assay and GLUT4 expression and translocation in C2C12 myotubes were conducted to evaluate antidiabetic potential of selected compounds (1–11). Compounds 7 and 9–11 displayed more potent α-glucosidase inhibitory activity (IC50 45.3–135.3 µM) than acarbose used as a positive control (IC50 264.7 µM), while only pomolic acid (5) increased GLUT4 translocation in C2C12 myotubes in a significant manner.
ER  -

MALANÍK, Milan; Jakub TREML; Renata KUBÍNOVÁ; Gabriela VÁVROVÁ; Michal ORAVEC; Jaromír MAREK; Karlygash ZHAPARKULOVA a Karel ŠMEJKAL. Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties. In \textit{Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland}. 2025.

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