Anti-inflammatory activity of Cynanchica bornmuelleri and bioassay-guided isolation of its secondary metabolites

ÖZTÜRK, Ceren; Milan MALANÍK; Jakub TREML a Hasan KIRMIZIBEKMEZ. Anti-inflammatory activity of Cynanchica bornmuelleri and bioassay-guided isolation of its secondary metabolites. In Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland. 2025.

Základní údaje

Originální název

Anti-inflammatory activity of Cynanchica bornmuelleri and bioassay-guided isolation of its secondary metabolites

Autoři

ÖZTÜRK, Ceren; Milan MALANÍK; Jakub TREML a Hasan KIRMIZIBEKMEZ

Vydání

Trends in Natural Product Research - PSE Young Scientists Meeting Wroclaw 2025, Poland, 2025

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Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ne

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Cynanchica; anti-inflammatory; iridoid

Štítky

ÚMF, ÚPL

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Anotace

V originále

The whole plant of C. bornmuelleri was extracted with EtOH. The crude EtOH extract was dispersed in H2O and then partitioned against n-hexane, EtOAc, and n-BuOH, respectively. The crude extract, and solvent fractions were evaluated for their NF-κB inhibitory activities in LPS-stimulated THP-1 cells. Amongst, nBuOH fraction showed remarkable inhibitory effect on NF-κB (61%) which is comparable to positive control, prednisolone at 2 µM. Sequential chromatographic separations on the n-BuOH fraction using Polyamide CC, Sephadex LH-20 CC, MPLC (C18 and SiO2), and semi-preparative HPLC yielded a new iridoid glycoside, bornmuellerioside (1), along with 11 known secondary metabolites.