Seeing the Spikes: The Future of Targetable Synthetic Voltage
Sensors

J 2025

Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors

FIALA, Tomáš; David SULZER a Dalibor SAMES

Základní údaje

Originální název

Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors

Autoři

FIALA, Tomáš ; David SULZER a Dalibor SAMES

Vydání

ACS Chemical Neuroscience, WASHINGTON, American Chemical Society, 2025, 1948-7193

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

voltage-sensitive dye; cell-selective targeting; membrane potential; fluorescent sensor; imagingprobe

Štítky

14313010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 7. 2025 15:10, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Measuring the transduction of electrical signals within neurons is a key capability in neuroscience. Fluorescent voltage sensitive dyes (VSDs) were early tools that complemented classical electrophysiology by enabling the optical recording of membrane potential changes from many cells simultaneously. Recent advances in the VSD field have led to bright and highly sensitive sensors that can be targeted to the desired cell populations in live brain tissue. Despite this progress, recently, protein-based genetically encoded voltage indicators (GEVIs) have become the go-to tools for targeted voltage imaging in complex environments. In this Perspective, we summarize progress in developing targetable VSDs, discuss areas where these synthetic sensors are or could become relevant, and outline hurdles that need to be overcome to promote the routine use of targetable VSDs in neuroscience research.

Citovat

FIALA, Tomáš; David SULZER a Dalibor SAMES. Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors. ACS Chemical Neuroscience. WASHINGTON: American Chemical Society, 2025, roč. 16, č. 5, s. 761-771. ISSN 1948-7193. Dostupné z: https://doi.org/10.1021/acschemneuro.4c00849.

@article{2506740,
   author = {Fiala, Tomáš and Sulzer, David and Sames, Dalibor},
   article_location = {WASHINGTON},
   article_number = {5},
   doi = {https://doi.org/10.1021/acschemneuro.4c00849},
   keywords = {voltage-sensitive dye; cell-selective targeting; membrane potential; fluorescent sensor; imagingprobe},
   language = {eng},
   issn = {1948-7193},
   journal = {ACS Chemical Neuroscience},
   title = {Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors},
   url = {https://pubs.acs.org/doi/10.1021/acschemneuro.4c00849},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2506740
AU  - Fiala, Tomáš - Sulzer, David - Sames, Dalibor
PY  - 2025
TI  - Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors
JF  - ACS Chemical Neuroscience
VL  - 16
IS  - 5
SP  - 761-771
EP  - 761-771
PB  - American Chemical Society
SN  - 19487193
KW  - voltage-sensitive dye
KW  - cell-selective targeting
KW  - membrane potential
KW  - fluorescent sensor
KW  - imagingprobe
UR  - https://pubs.acs.org/doi/10.1021/acschemneuro.4c00849
N2  - Measuring the transduction of electrical signals within neurons is a key capability in neuroscience. Fluorescent voltage sensitive dyes (VSDs) were early tools that complemented classical electrophysiology by enabling the optical recording of membrane potential changes from many cells simultaneously. Recent advances in the VSD field have led to bright and highly sensitive sensors that can be targeted to the desired cell populations in live brain tissue. Despite this progress, recently, protein-based genetically encoded voltage indicators (GEVIs) have become the go-to tools for targeted voltage imaging in complex environments. In this Perspective, we summarize progress in developing targetable VSDs, discuss areas where these synthetic sensors are or could become relevant, and outline hurdles that need to be overcome to promote the routine use of targetable VSDs in neuroscience research.
ER  -

FIALA, Tomáš; David SULZER a Dalibor SAMES. Seeing the Spikes: The Future of Targetable Synthetic Voltage Sensors. \textit{ACS Chemical Neuroscience}. WASHINGTON: American Chemical Society, 2025, roč.~16, č.~5, s.~761-771. ISSN~1948-7193. Dostupné z: https://doi.org/10.1021/acschemneuro.4c00849.

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