Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry
GIUSEPPE, De Luca; Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV et al.
Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry
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GIUSEPPE, De Luca; Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV; Zan ZIMBAKOV; Miha CERCEK; Lisette Okkels JENSEN; Poay Huan LOH; Lucian CALMAC; Roura i Ferrer GERARD; Alexandre QUADROS; Marek MILEWSKI; Fortunato Scotto D'UCCIO; von Birgelen CLEMENS; Francesco VERSACI; Ten Berg JURRIEN; Gianni CASELLA; Aaron Wong Sung LUNG; Petr KALA; Jose Luis Diez GIL; Xavier CARRILLO; Maurits DIRKSEN; Victor M BECERRA-MUNOZ; Michael Kang-yin LEE; Dafsah Arifa JUZAR; Rodrigo de Moura JOAQUIM; Roberto PALADINO; Davor MILICIC; Periklis DAVLOUROS; Nikola BAKRACESKI; Filippo ZILIO; Luca DONAZZAN; Adriaan KRAAIJEVELD; Gennaro GALASSO; Lux ARPAD; Marinucci LUCIA; Guiducci VINCENZO; Maurizio MENICHELLI; Alessandra SCOCCIA; Aylin Hatice YAMAC; Kadir Ugur MERT; Xacobe Flores RIOS; Tomas KOVARNIK; Michal KIDAWA; Jose MOREU; Vincent FLAVIEN; Enrico FABRIS; Inigo Lozano MARTINEZ-LUENGAS; Francisco Bosa OJEDA; Robert RODRIGUEZ-SANCHEZ; Gianluca CAIAZZO; Giuseppe CIRRINCIONE; Hsien-Li KAO; Juan Sanchis FORES; Luigi VIGNALI; Helder PEREIRA; Stephane MANZO; Santiago ORDONEZ; Alev Arat OZKAN; Bruno SCHELLER; Heidi LEHTOLA; Rui TELES; Christos MANTIS; Ylitalo ANTTI; Joao Antonio Brum SILVEIRA; Rodrigo ZONI; Ivan BESSONOV; Stefano SAVONITTO; George KOCHIADAKIS; Dimitrios ALEXOPULOS; Carlos E URIBE; John KANAKAKIS; Benjamin FAURIE; Gabriele GABRIELLI; Alejandro Gutierrez BARRIOS; Juan Pablo BACHINI; Alex ROCHA; Frankie Chor-Cheung TAM; Alfredo RODRIGUEZ; Antonia Anna LUKITO; Anne BELLEMAIN-APPAIX; Gustavo PESSAH; Giuliana CORTESE; Guido PARODI; Mohammed Abed BURGADHA; Elvin KEDHI; Pablo LAMELAS; Harry SURYAPRANATA; Matteo NARDIN a Monica VERDOIA
Background and aim Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic. Methods and results The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020. Primary study endpoint of this analysis was in-hospital mortality. Secondary endpoints were postprocedural TIMI 0-2 flow and 30-day mortality. Our population is represented by 16083 STEMI patients. A total of 3812 (23,7 %) patients suffered from diabetes. They were older, more often males as compared to non-diabetes. Diabetic patients were less often active smokers and had less often a positive family history of CAD, but they were more often affected by hypertension and hypercholesterolemia, with higher prevalence of previous STEMI and previous CABG. Diabetic patients had longer ischemia time, had more often anterior MI, cardiogenic shock, rescue PCI and multivessel disease. They had less often out-of-hospital cardiac arrest and in-stent thrombosis, received more often a mechanical support, received less often a coronary stent and DES. Diabetes was associated with a significantly impaired postprocedural TIMI flow (TIMI 0-2: 9.8 % vs 7.2 %, adjusted OR [95 % CI] = 1.17 [1.02-1.38], p = 0.024) and higher mortality (in-hospital: 9.1 % vs 4.8 %, Adjusted OR [95 % CI] = 1.70 [1.43-2.02], p < 0.001; 30-day mortality: 10.8 % vs 6 %, Adjusted HR [95 % CI] = 1.46 [1.26-1.68], p < 0.001) as compared to non-diabetes, particularly during the pandemic. Conclusions Our study showed that in a contemporary STEMI population undergoing PPCI, diabetes is significantly associated with impaired epicardial reperfusion that translates into higher in-hospital and 30-day mortality, particularly during the pandemic.
GIUSEPPE, De Luca; Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV; Zan ZIMBAKOV; Miha CERCEK; Lisette Okkels JENSEN; Poay Huan LOH; Lucian CALMAC; Roura i Ferrer GERARD; Alexandre QUADROS; Marek MILEWSKI; Fortunato Scotto D'UCCIO; von Birgelen CLEMENS; Francesco VERSACI; Ten Berg JURRIEN; Gianni CASELLA; Aaron Wong Sung LUNG; Petr KALA; Jose Luis Diez GIL; Xavier CARRILLO; Maurits DIRKSEN; Victor M BECERRA-MUNOZ; Michael Kang-yin LEE; Dafsah Arifa JUZAR; Rodrigo de Moura JOAQUIM; Roberto PALADINO; Davor MILICIC; Periklis DAVLOUROS; Nikola BAKRACESKI; Filippo ZILIO; Luca DONAZZAN; Adriaan KRAAIJEVELD; Gennaro GALASSO; Lux ARPAD; Marinucci LUCIA; Guiducci VINCENZO; Maurizio MENICHELLI; Alessandra SCOCCIA; Aylin Hatice YAMAC; Kadir Ugur MERT; Xacobe Flores RIOS; Tomas KOVARNIK; Michal KIDAWA; Jose MOREU; Vincent FLAVIEN; Enrico FABRIS; Inigo Lozano MARTINEZ-LUENGAS; Francisco Bosa OJEDA; Robert RODRIGUEZ-SANCHEZ; Gianluca CAIAZZO; Giuseppe CIRRINCIONE; Hsien-Li KAO; Juan Sanchis FORES; Luigi VIGNALI; Helder PEREIRA; Stephane MANZO; Santiago ORDONEZ; Alev Arat OZKAN; Bruno SCHELLER; Heidi LEHTOLA; Rui TELES; Christos MANTIS; Ylitalo ANTTI; Joao Antonio Brum SILVEIRA; Rodrigo ZONI; Ivan BESSONOV; Stefano SAVONITTO; George KOCHIADAKIS; Dimitrios ALEXOPULOS; Carlos E URIBE; John KANAKAKIS; Benjamin FAURIE; Gabriele GABRIELLI; Alejandro Gutierrez BARRIOS; Juan Pablo BACHINI; Alex ROCHA; Frankie Chor-Cheung TAM; Alfredo RODRIGUEZ; Antonia Anna LUKITO; Anne BELLEMAIN-APPAIX; Gustavo PESSAH; Giuliana CORTESE; Guido PARODI; Mohammed Abed BURGADHA; Elvin KEDHI; Pablo LAMELAS; Harry SURYAPRANATA; Matteo NARDIN a Monica VERDOIA. Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. London: ELSEVIER SCI LTD, 2025, roč. 35, č. 5, s. 1-9. ISSN 0939-4753. Dostupné z: https://doi.org/10.1016/j.numecd.2024.09.031.
@article{2507595, author = {Giuseppe, De Luca and Algowhary, Magdy and Uguz, Berat and Oliveira, Dinaldo C and Ganyukov, Vladimir and Zimbakov, Zan and Cercek, Miha and Jensen, Lisette Okkels and Loh, Poay Huan and Calmac, Lucian and Gerard, Roura i Ferrer and Quadros, Alexandre and Milewski, Marek and D'Uccio, Fortunato Scotto and Clemens, von Birgelen and Versaci, Francesco and Jurrien, Ten Berg and Casella, Gianni and Lung, Aaron Wong Sung and Kala, Petr and Gil, Jose Luis Diez and Carrillo, Xavier and Dirksen, Maurits and BecerraandMunoz, Victor M and Lee, Michael Kangandyin and Juzar, Dafsah Arifa and Joaquim, Rodrigo de Moura and Paladino, Roberto and Milicic, Davor and Davlouros, Periklis and Bakraceski, Nikola and Zilio, Filippo and Donazzan, Luca and Kraaijeveld, Adriaan and Galasso, Gennaro and Arpad, Lux and Lucia, Marinucci and Vincenzo, Guiducci and Menichelli, Maurizio and Scoccia, Alessandra and Yamac, Aylin Hatice and Mert, Kadir Ugur and Rios, Xacobe Flores and Kovarnik, Tomas and Kidawa, Michal and Moreu, Jose and Flavien, Vincent and Fabris, Enrico and MartinezandLuengas, Inigo Lozano and Ojeda, Francisco Bosa and RodriguezandSanchez, Robert and Caiazzo, Gianluca and Cirrincione, Giuseppe and Kao, HsienandLi and Fores, Juan Sanchis and Vignali, Luigi and Pereira, Helder and Manzo, Stephane and Ordonez, Santiago and Ozkan, Alev Arat and Scheller, Bruno and Lehtola, Heidi and Teles, Rui and Mantis, Christos and Antti, Ylitalo and Silveira, Joao Antonio Brum and Zoni, Rodrigo and Bessonov, Ivan and Savonitto, Stefano and Kochiadakis, George and Alexopulos, Dimitrios and Uribe, Carlos E and Kanakakis, John and Faurie, Benjamin and Gabrielli, Gabriele and Barrios, Alejandro Gutierrez and Bachini, Juan Pablo and Rocha, Alex and Tam, Frankie ChorandCheung and Rodriguez, Alfredo and Lukito, Antonia Anna and BellemainandAppaix, Anne and Pessah, Gustavo and Cortese, Giuliana and Parodi, Guido and Burgadha, Mohammed Abed and Kedhi, Elvin and Lamelas, Pablo and Suryapranata, Harry and Nardin, Matteo and Verdoia, Monica}, article_location = {London}, article_number = {5}, doi = {https://doi.org/10.1016/j.numecd.2024.09.031}, keywords = {Diabetes mellitus; ST-Segment myocardial infarction; PCI; COVID}, language = {eng}, issn = {0939-4753}, journal = {NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES}, title = {Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry}, url = {https://www.sciencedirect.com/science/article/pii/S093947532400382X?via%3Dihub}, volume = {35}, year = {2025} }
TY - JOUR ID - 2507595 AU - Giuseppe, De Luca - Algowhary, Magdy - Uguz, Berat - Oliveira, Dinaldo C - Ganyukov, Vladimir - Zimbakov, Zan - Cercek, Miha - Jensen, Lisette Okkels - Loh, Poay Huan - Calmac, Lucian - Gerard, Roura i Ferrer - Quadros, Alexandre - Milewski, Marek - D'Uccio, Fortunato Scotto - Clemens, von Birgelen - Versaci, Francesco - Jurrien, Ten Berg - Casella, Gianni - Lung, Aaron Wong Sung - Kala, Petr - Gil, Jose Luis Diez - Carrillo, Xavier - Dirksen, Maurits - Becerra-Munoz, Victor M - Lee, Michael Kang-yin - Juzar, Dafsah Arifa - Joaquim, Rodrigo de Moura - Paladino, Roberto - Milicic, Davor - Davlouros, Periklis - Bakraceski, Nikola - Zilio, Filippo - Donazzan, Luca - Kraaijeveld, Adriaan - Galasso, Gennaro - Arpad, Lux - Lucia, Marinucci - Vincenzo, Guiducci - Menichelli, Maurizio - Scoccia, Alessandra - Yamac, Aylin Hatice - Mert, Kadir Ugur - Rios, Xacobe Flores - Kovarnik, Tomas - Kidawa, Michal - Moreu, Jose - Flavien, Vincent - Fabris, Enrico - Martinez-Luengas, Inigo Lozano - Ojeda, Francisco Bosa - Rodriguez-Sanchez, Robert - Caiazzo, Gianluca - Cirrincione, Giuseppe - Kao, Hsien-Li - Fores, Juan Sanchis - Vignali, Luigi - Pereira, Helder - Manzo, Stephane - Ordonez, Santiago - Ozkan, Alev Arat - Scheller, Bruno - Lehtola, Heidi - Teles, Rui - Mantis, Christos - Antti, Ylitalo - Silveira, Joao Antonio Brum - Zoni, Rodrigo - Bessonov, Ivan - Savonitto, Stefano - Kochiadakis, George - Alexopulos, Dimitrios - Uribe, Carlos E - Kanakakis, John - Faurie, Benjamin - Gabrielli, Gabriele - Barrios, Alejandro Gutierrez - Bachini, Juan Pablo - Rocha, Alex - Tam, Frankie Chor-Cheung - Rodriguez, Alfredo - Lukito, Antonia Anna - Bellemain-Appaix, Anne - Pessah, Gustavo - Cortese, Giuliana - Parodi, Guido - Burgadha, Mohammed Abed - Kedhi, Elvin - Lamelas, Pablo - Suryapranata, Harry - Nardin, Matteo - Verdoia, Monica PY - 2025 TI - Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry JF - NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES VL - 35 IS - 5 SP - 1-9 EP - 1-9 PB - ELSEVIER SCI LTD SN - 09394753 KW - Diabetes mellitus KW - ST-Segment myocardial infarction KW - PCI KW - COVID UR - https://www.sciencedirect.com/science/article/pii/S093947532400382X?via%3Dihub N2 - Background and aim Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic. Methods and results The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020. Primary study endpoint of this analysis was in-hospital mortality. Secondary endpoints were postprocedural TIMI 0-2 flow and 30-day mortality. Our population is represented by 16083 STEMI patients. A total of 3812 (23,7 %) patients suffered from diabetes. They were older, more often males as compared to non-diabetes. Diabetic patients were less often active smokers and had less often a positive family history of CAD, but they were more often affected by hypertension and hypercholesterolemia, with higher prevalence of previous STEMI and previous CABG. Diabetic patients had longer ischemia time, had more often anterior MI, cardiogenic shock, rescue PCI and multivessel disease. They had less often out-of-hospital cardiac arrest and in-stent thrombosis, received more often a mechanical support, received less often a coronary stent and DES. Diabetes was associated with a significantly impaired postprocedural TIMI flow (TIMI 0-2: 9.8 % vs 7.2 %, adjusted OR [95 % CI] = 1.17 [1.02-1.38], p = 0.024) and higher mortality (in-hospital: 9.1 % vs 4.8 %, Adjusted OR [95 % CI] = 1.70 [1.43-2.02], p < 0.001; 30-day mortality: 10.8 % vs 6 %, Adjusted HR [95 % CI] = 1.46 [1.26-1.68], p < 0.001) as compared to non-diabetes, particularly during the pandemic. Conclusions Our study showed that in a contemporary STEMI population undergoing PPCI, diabetes is significantly associated with impaired epicardial reperfusion that translates into higher in-hospital and 30-day mortality, particularly during the pandemic. ER -
GIUSEPPE, De Luca; Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV; Zan ZIMBAKOV; Miha CERCEK; Lisette Okkels JENSEN; Poay Huan LOH; Lucian CALMAC; Roura i Ferrer GERARD; Alexandre QUADROS; Marek MILEWSKI; Fortunato Scotto D'UCCIO; von Birgelen CLEMENS; Francesco VERSACI; Ten Berg JURRIEN; Gianni CASELLA; Aaron Wong Sung LUNG; Petr KALA; Jose Luis Diez GIL; Xavier CARRILLO; Maurits DIRKSEN; Victor M BECERRA-MUNOZ; Michael Kang-yin LEE; Dafsah Arifa JUZAR; Rodrigo de Moura JOAQUIM; Roberto PALADINO; Davor MILICIC; Periklis DAVLOUROS; Nikola BAKRACESKI; Filippo ZILIO; Luca DONAZZAN; Adriaan KRAAIJEVELD; Gennaro GALASSO; Lux ARPAD; Marinucci LUCIA; Guiducci VINCENZO; Maurizio MENICHELLI; Alessandra SCOCCIA; Aylin Hatice YAMAC; Kadir Ugur MERT; Xacobe Flores RIOS; Tomas KOVARNIK; Michal KIDAWA; Jose MOREU; Vincent FLAVIEN; Enrico FABRIS; Inigo Lozano MARTINEZ-LUENGAS; Francisco Bosa OJEDA; Robert RODRIGUEZ-SANCHEZ; Gianluca CAIAZZO; Giuseppe CIRRINCIONE; Hsien-Li KAO; Juan Sanchis FORES; Luigi VIGNALI; Helder PEREIRA; Stephane MANZO; Santiago ORDONEZ; Alev Arat OZKAN; Bruno SCHELLER; Heidi LEHTOLA; Rui TELES; Christos MANTIS; Ylitalo ANTTI; Joao Antonio Brum SILVEIRA; Rodrigo ZONI; Ivan BESSONOV; Stefano SAVONITTO; George KOCHIADAKIS; Dimitrios ALEXOPULOS; Carlos E URIBE; John KANAKAKIS; Benjamin FAURIE; Gabriele GABRIELLI; Alejandro Gutierrez BARRIOS; Juan Pablo BACHINI; Alex ROCHA; Frankie Chor-Cheung TAM; Alfredo RODRIGUEZ; Antonia Anna LUKITO; Anne BELLEMAIN-APPAIX; Gustavo PESSAH; Giuliana CORTESE; Guido PARODI; Mohammed Abed BURGADHA; Elvin KEDHI; Pablo LAMELAS; Harry SURYAPRANATA; Matteo NARDIN a Monica VERDOIA. Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry. \textit{NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES}. London: ELSEVIER SCI LTD, 2025, roč.~35, č.~5, s.~1-9. ISSN~0939-4753. Dostupné z: https://doi.org/10.1016/j.numecd.2024.09.031.