Human biomonitoring of essential and toxic trace elements
(heavy metals and metalloids) in urine of children, teenagers,
and young adults from a Central European Cohort in the Czech
Republic

J 2025

Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic

SHARMA, Brij Mohan; Klára KOMPRDOVÁ; Katarína LÖRINCZOVÁ; Jan KUTA; Petra PŘIBYLOVÁ et al.

Základní údaje

Originální název

Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic

Autoři

SHARMA, Brij Mohan; Klára KOMPRDOVÁ; Katarína LÖRINCZOVÁ ; Jan KUTA; Petra PŘIBYLOVÁ; Martin SCHERINGER; Ludmila ŠEBEJOVÁ; Pavel PILER ; Martin ZVONAŘ a Jana KLÁNOVÁ

Vydání

Journal of Exposure Science and Environmental Epidemiology, Springer Nature, 2025, 1559-0631

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00141542

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Trace elements; Heavy metals; Human biomonitoring; Urine; Human exposure

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 6. 2026 08:38, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background: Exposure to toxic trace elements, which include metals and metalloids, can induce adverse health effects, including life-threatening diseases. Conversely, essential trace elements are vital for bodily functions, yet their excessive (or inadequate) intake may pose health risks. Therefore, identifying levels and determinants of exposure to trace elements is crucial for safeguarding human health. Methods: The present study analyzed urinary concentrations of 14 trace elements (arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, selenium, thallium, and zinc) and their exposure determinants in 711 individuals, spanning from children to young adults from a Central European population from the Czech Republic. Multivariate linear regression and non-parametric Kruskal-Wallis ANOVA were used to investigate exposure determinants. Estimates of 95th percentile concentrations and confidence intervals were carried out to establish reference values (RV95). The study also assessed the percentage of population exceeding health-based guidance values (GVs) to gauge health risks. Results: Young adults showed elevated toxic element concentrations, whereas children exhibited higher concentrations of essential elements. Mercury concentrations were associated with both dental amalgam filling count and seafood intake; arsenic concentrations were associated with seafood, rice, and mushroom consumption. Mushroom consumption also influenced lead concentrations. Sex differences were found for cadmium, zinc, nickel, and cobalt. Between 17.9% and 25% of the participants exceeded recommended GV for arsenic, while 2.4% to 2.8% exceeded GV for cadmium. Only one participant exceeded the GV for mercury, and none exceeded GVs for chromium and thallium. Essential trace elements' GVs were surpassed by 38% to 68.5% participants for zinc, 1.3% to 1.8% for molybdenum, and 0.2% to 0.3% for selenium. Impact: The present study examines trace element exposure in a Central European population from the Czech Republic, unveiling elevated exposure levels of toxic elements in young adults and essential elements in children. It elucidates key determinants of trace element exposure, including dietary and lifestyle indicators as well as dental amalgam fillings. Additionally, the study establishes novel reference values and a comparison with established health-based human biomonitoring guidance values, which are crucial for public health decision-making. This comprehensive biomonitoring study provides essential data to inform public health policies and interventions.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2023069, projekt VaV

Název: Výzkumná infrastruktura RECETOX

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

SHARMA, Brij Mohan; Klára KOMPRDOVÁ; Katarína LÖRINCZOVÁ; Jan KUTA; Petra PŘIBYLOVÁ; Martin SCHERINGER; Ludmila ŠEBEJOVÁ; Pavel PILER; Martin ZVONAŘ a Jana KLÁNOVÁ. Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic. Journal of Exposure Science and Environmental Epidemiology. Springer Nature, 2025, roč. 35, č. 5, s. 730-745. ISSN 1559-0631. Dostupné z: https://doi.org/10.1038/s41370-024-00724-4.

@article{2507685,
   author = {Sharma, Brij Mohan and Komprdová, Klára and Lörinczová, Katarína and Kuta, Jan and Přibylová, Petra and Scheringer, Martin and Šebejová, Ludmila and Piler, Pavel and Zvonař, Martin and Klánová, Jana},
   article_number = {5},
   doi = {https://doi.org/10.1038/s41370-024-00724-4},
   keywords = {Trace elements; Heavy metals; Human biomonitoring; Urine; Human exposure},
   language = {eng},
   issn = {1559-0631},
   journal = {Journal of Exposure Science and Environmental Epidemiology},
   title = {Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic},
   url = {https://www.nature.com/articles/s41370-024-00724-4},
   volume = {35},
   year = {2025}
}

TY  - JOUR
ID  - 2507685
AU  - Sharma, Brij Mohan - Komprdová, Klára - Lörinczová, Katarína - Kuta, Jan - Přibylová, Petra - Scheringer, Martin - Šebejová, Ludmila - Piler, Pavel - Zvonař, Martin - Klánová, Jana
PY  - 2025
TI  - Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic
JF  - Journal of Exposure Science and Environmental Epidemiology
VL  - 35
IS  - 5
SP  - 730-745
EP  - 730-745
PB  - Springer Nature
SN  - 15590631
KW  - Trace elements
KW  - Heavy metals
KW  - Human biomonitoring
KW  - Urine
KW  - Human exposure
UR  - https://www.nature.com/articles/s41370-024-00724-4
N2  - Background: Exposure to toxic trace elements, which include metals and metalloids, can induce adverse health effects, including life-threatening diseases. Conversely, essential trace elements are vital for bodily functions, yet their excessive (or inadequate) intake may pose health risks. Therefore, identifying levels and determinants of exposure to trace elements is crucial for safeguarding human health. Methods: The present study analyzed urinary concentrations of 14 trace elements (arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, selenium, thallium, and zinc) and their exposure determinants in 711 individuals, spanning from children to young adults from a Central European population from the Czech Republic. Multivariate linear regression and non-parametric Kruskal-Wallis ANOVA were used to investigate exposure determinants. Estimates of 95th percentile concentrations and confidence intervals were carried out to establish reference values (RV95). The study also assessed the percentage of population exceeding health-based guidance values (GVs) to gauge health risks. Results: Young adults showed elevated toxic element concentrations, whereas children exhibited higher concentrations of essential elements. Mercury concentrations were associated with both dental amalgam filling count and seafood intake; arsenic concentrations were associated with seafood, rice, and mushroom consumption. Mushroom consumption also influenced lead concentrations. Sex differences were found for cadmium, zinc, nickel, and cobalt. Between 17.9% and 25% of the participants exceeded recommended GV for arsenic, while 2.4% to 2.8% exceeded GV for cadmium. Only one participant exceeded the GV for mercury, and none exceeded GVs for chromium and thallium. Essential trace elements' GVs were surpassed by 38% to 68.5% participants for zinc, 1.3% to 1.8% for molybdenum, and 0.2% to 0.3% for selenium. Impact: The present study examines trace element exposure in a Central European population from the Czech Republic, unveiling elevated exposure levels of toxic elements in young adults and essential elements in children. It elucidates key determinants of trace element exposure, including dietary and lifestyle indicators as well as dental amalgam fillings. Additionally, the study establishes novel reference values and a comparison with established health-based human biomonitoring guidance values, which are crucial for public health decision-making. This comprehensive biomonitoring study provides essential data to inform public health policies and interventions.
ER  -

SHARMA, Brij Mohan; Klára KOMPRDOVÁ; Katarína LÖRINCZOVÁ; Jan KUTA; Petra PŘIBYLOVÁ; Martin SCHERINGER; Ludmila ŠEBEJOVÁ; Pavel PILER; Martin ZVONAŘ a Jana KLÁNOVÁ. Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic. \textit{Journal of Exposure Science and Environmental Epidemiology}. Springer Nature, 2025, roč.~35, č.~5, s.~730-745. ISSN~1559-0631. Dostupné z: https://doi.org/10.1038/s41370-024-00724-4.

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