Comprehensive analysis of spray drying process variables to
improve microparticle properties for effective lung delivery

J 2025

Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery

PEŠTÁLOVÁ, Andrea; Sylvie PAVLOKOVÁ a Jan GAJDZIOK

Základní údaje

Originální název

Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery

Autoři

PEŠTÁLOVÁ, Andrea; Sylvie PAVLOKOVÁ a Jan GAJDZIOK

Vydání

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, AMSTERDAM, ELSEVIER, 2025, 1773-2247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.900 v roce 2024

Organizační jednotka

Farmaceutická fakulta

DOI

https://doi.org/10.1016/j.jddst.2025.107167

UT WoS

001513017100002

EID Scopus

2-s2.0-105007698867

Klíčová slova anglicky

Microparticles; Spray drying; Inhalation; Aerodynamic diameter; Process parameters; Design of experiment

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 7. 2025 13:03, Mgr. Irena Doubková

Anotace

V originále

Inhalation offers several benefits over conventional routes of drug delivery, including rapid onset of action, reduced systemic side effects, and improved patient compliance. A crucial role in pulmonary drug delivery has the aerodynamic diameter of applied particles, influencing their behavior and deposition in the respiratory tract. Precise control of this parameter through spray drying conditions is essential for efficient drug delivery. This study employed a design of experiments approach to investigate how spray drying parameters influence the properties of microparticles for pulmonary delivery. Microparticles were evaluated for the most important properties, such as aerodynamic and geometric diameter, geometric standard deviation, and fine particle fraction, using an aerodynamic particle spectrometer and laser diffraction. Their morphology was assessed from SEM images. Initially, the effects of drying temperature, pump speed, and air flow rate were examined, followed by an assessment of nozzle diameter. The significance of the individual factors was determined using ANOVA, supported by visualization techniques, such as box and whisker plots and interaction plots. This integrated approach comprehensively evaluated the effects and interactions of spray drying variables. It highlighted the study's novelty in systematically examining and quantifying the impact of these parameters on microparticle properties. Particles with a lower MMAD (4.91 +/- 0.17 mu m) and higher FPF (52.20 +/- 3.69 %) were achieved by increasing air flow rate, reducing pump speed, and using a smaller nozzle diameter. The findings are significant for advancing the field of pulmonary drug delivery by offering new insights into optimizing spray drying processes for the preparation of microparticles with tuned properties connected to improved therapeutic efficacy.

Citovat

PEŠTÁLOVÁ, Andrea; Sylvie PAVLOKOVÁ a Jan GAJDZIOK. Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. AMSTERDAM: ELSEVIER, 2025, roč. 111, September, s. 1-12. ISSN 1773-2247. Dostupné z: https://doi.org/10.1016/j.jddst.2025.107167.

@article{2507882,
   author = {Peštálová, Andrea and Pavloková, Sylvie and Gajdziok, Jan},
   article_location = {AMSTERDAM},
   article_number = {September},
   doi = {https://doi.org/10.1016/j.jddst.2025.107167},
   keywords = {Microparticles; Spray drying; Inhalation; Aerodynamic diameter; Process parameters; Design of experiment},
   language = {eng},
   issn = {1773-2247},
   journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY},
   title = {Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery},
   url = {https://www.sciencedirect.com/science/article/pii/S1773224725005702?via%3Dihub},
   volume = {111},
   year = {2025}
}

TY  - JOUR
ID  - 2507882
AU  - Peštálová, Andrea - Pavloková, Sylvie - Gajdziok, Jan
PY  - 2025
TI  - Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery
JF  - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
VL  - 111
IS  - September
SP  - 1-12
EP  - 1-12
PB  - ELSEVIER
SN  - 17732247
KW  - Microparticles
KW  - Spray drying
KW  - Inhalation
KW  - Aerodynamic diameter
KW  - Process parameters
KW  - Design of experiment
UR  - https://www.sciencedirect.com/science/article/pii/S1773224725005702?via%3Dihub
N2  - Inhalation offers several benefits over conventional routes of drug delivery, including rapid onset of action, reduced systemic side effects, and improved patient compliance. A crucial role in pulmonary drug delivery has the aerodynamic diameter of applied particles, influencing their behavior and deposition in the respiratory tract. Precise control of this parameter through spray drying conditions is essential for efficient drug delivery. This study employed a design of experiments approach to investigate how spray drying parameters influence the properties of microparticles for pulmonary delivery. Microparticles were evaluated for the most important properties, such as aerodynamic and geometric diameter, geometric standard deviation, and fine particle fraction, using an aerodynamic particle spectrometer and laser diffraction. Their morphology was assessed from SEM images. Initially, the effects of drying temperature, pump speed, and air flow rate were examined, followed by an assessment of nozzle diameter. The significance of the individual factors was determined using ANOVA, supported by visualization techniques, such as box and whisker plots and interaction plots. This integrated approach comprehensively evaluated the effects and interactions of spray drying variables. It highlighted the study's novelty in systematically examining and quantifying the impact of these parameters on microparticle properties. Particles with a lower MMAD (4.91 +/- 0.17 mu m) and higher FPF (52.20 +/- 3.69 %) were achieved by increasing air flow rate, reducing pump speed, and using a smaller nozzle diameter. The findings are significant for advancing the field of pulmonary drug delivery by offering new insights into optimizing spray drying processes for the preparation of microparticles with tuned properties connected to improved therapeutic efficacy.
ER  -

PEŠTÁLOVÁ, Andrea; Sylvie PAVLOKOVÁ a Jan GAJDZIOK. Comprehensive analysis of spray drying process variables to improve microparticle properties for effective lung delivery. \textit{JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}. AMSTERDAM: ELSEVIER, 2025, roč.~111, September, s.~1-12. ISSN~1773-2247. Dostupné z: https://doi.org/10.1016/j.jddst.2025.107167.

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