Repeated administration of AMPA/kainate antagonists transiently
suppresses nicotine-seeking in an operant rat model

J 2025

Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model

HRICKOVÁ, Mária; Petra AMCHOVÁ a Jana RUDÁ

Základní údaje

Originální název

Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model

Název česky

Opakované podávání antagonistů AMPA/kainátu přechodně potlačuje vyhledávání nikotinu na operantním potkaním modelu

Autoři

HRICKOVÁ, Mária; Petra AMCHOVÁ a Jana RUDÁ

Vydání

BEHAVIOURAL BRAIN RESEARCH, NETHERLANDS, ELSEVIER, 2025, 0166-4328

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.300 v roce 2024

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.bbr.2025.115742

UT WoS

001548873100001

Klíčová slova anglicky

AMPA/kainate; CNQX; NBQX; Nicotine; Self-administration; Reinstatement

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 9. 2025 09:07, doc. PharmDr. Jana Rudá, Ph.D.

Anotace

V originále

This study evaluated the impact of repeated intravenous administration of AMPA/kainate receptor antagonists, NBQX and CNQX, on the operant nicotine self-administration in rats. Wistar rats were subjected to operant intravenous self-administration of nicotine under a fixed ratio 1 schedule of reinforcement. During the maintenance phase of self-administration, 5 mg/kg intravenous NBQX was administered daily prior to the session for a duration of 10 days. Subsequently, the rats underwent a forced abstinence period, remaining in their home cages for two weeks. Following the abstinence, a reinstatement session was conducted. During the final 3 days of abstinence and preceding the reinstatement session, the animals were treated with either NBQX or CNQX (5 and 6 mg/kg intravenously, respectively) to assess their effect on drug-seeking behavior. A ten-day treatment with NBQX did not have any significant influence on the nicotine intake. Repeated administration of NBQX or CNQX before reinstatement had no effect on nicotine-seeking behavior in terms of total numbers of operant responses. However, both of these ligands decreased the number of active nose-pokes (nicotine-seeking) in the first 20 min of the reinstatement session. While no effect of repeated NBQX treatment on nicotine intake was observed, this study reports a transient effect of repeated NBQX or CNQX treatment in the reinstatement of nicotine-seeking behavior in an operant IVSA model. Further pharmacokinetic studies may help optimize behavioral protocols assessing the potential role of AMPA/kainate antagonists in the field of nicotine addiction research where current evidence remains limited.

Návaznosti

MUNI/A/1722/2024, interní kód MU

Název: Specifický farmakologický výzkum v oblasti farmakokinetiky, behaviorální neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masarykova univerzita, Specifický farmakologický výzkum v oblasti farmakokinetiky, behaviorální neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Citovat

HRICKOVÁ, Mária; Petra AMCHOVÁ a Jana RUDÁ. Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model. BEHAVIOURAL BRAIN RESEARCH. NETHERLANDS: ELSEVIER, 2025, roč. 494, č. 115742, s. 1-8. ISSN 0166-4328. Dostupné z: https://doi.org/10.1016/j.bbr.2025.115742.

@article{2508797,
   author = {Hricková, Mária and Amchová, Petra and Rudá, Jana},
   article_location = {NETHERLANDS},
   article_number = {115742},
   doi = {https://doi.org/10.1016/j.bbr.2025.115742},
   keywords = {AMPA/kainate; CNQX; NBQX; Nicotine; Self-administration; Reinstatement},
   language = {eng},
   issn = {0166-4328},
   journal = {BEHAVIOURAL BRAIN RESEARCH},
   title = {Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model},
   url = {https://www.sciencedirect.com/science/article/pii/S0166432825003298},
   volume = {494},
   year = {2025}
}

TY  - JOUR
ID  - 2508797
AU  - Hricková, Mária - Amchová, Petra - Rudá, Jana
PY  - 2025
TI  - Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model
JF  - BEHAVIOURAL BRAIN RESEARCH
VL  - 494
IS  - 115742
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER
SN  - 01664328
KW  - AMPA/kainate
KW  - CNQX
KW  - NBQX
KW  - Nicotine
KW  - Self-administration
KW  - Reinstatement
UR  - https://www.sciencedirect.com/science/article/pii/S0166432825003298
N2  - This study evaluated the impact of repeated intravenous administration of AMPA/kainate receptor antagonists, NBQX and CNQX, on the operant nicotine self-administration in rats. Wistar rats were subjected to operant intravenous self-administration of nicotine under a fixed ratio 1 schedule of reinforcement. During the maintenance phase of self-administration, 5 mg/kg intravenous NBQX was administered daily prior to the session for a duration of 10 days. Subsequently, the rats underwent a forced abstinence period, remaining in their home cages for two weeks. Following the abstinence, a reinstatement session was conducted. During the final 3 days of abstinence and preceding the reinstatement session, the animals were treated with either NBQX or CNQX (5 and 6 mg/kg intravenously, respectively) to assess their effect on drug-seeking behavior. A ten-day treatment with NBQX did not have any significant influence on the nicotine intake. Repeated administration of NBQX or CNQX before reinstatement had no effect on nicotine-seeking behavior in terms of total numbers of operant responses. However, both of these ligands decreased the number of active nose-pokes (nicotine-seeking) in the first 20 min of the reinstatement session. While no effect of repeated NBQX treatment on nicotine intake was observed, this study reports a transient effect of repeated NBQX or CNQX treatment in the reinstatement of nicotine-seeking behavior in an operant IVSA model. Further pharmacokinetic studies may help optimize behavioral protocols assessing the potential role of AMPA/kainate antagonists in the field of nicotine addiction research where current evidence remains limited.
ER  -

HRICKOVÁ, Mária; Petra AMCHOVÁ a Jana RUDÁ. Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model. \textit{BEHAVIOURAL BRAIN RESEARCH}. NETHERLANDS: ELSEVIER, 2025, roč.~494, č.~115742, s.~1-8. ISSN~0166-4328. Dostupné z: https://doi.org/10.1016/j.bbr.2025.115742.

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