Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study
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RONCAGLIA, Eleonora; Enrico GAFFO; Giulia CALABRETTO; Moritz FUERSTENAU; Kerry A ROGERS; Panagiotis BALIAKAS; Chenghua CUI; Cecelia MILLER; Claudia HAFERLACH; Karla PLEVOVÁ; David OSCIER; Zadie DAVIS; Florence NGUYEN-KHAC; Gian Matteo RIGOLIN; Anastasia ATHANASIADOU; Fanny BARAN-MARSZAK; Alberto VALIENTE; Maria Jose TEROL; Pau ABRISQUETA; Blanca ESPINET; Anna PUIGGROS; Annalisa MARTINES; Laura BONALDI; Francesca Romana MAURO; Lydia SCARFO; Thomas CHATZIKONSTANTINOU; Eugen TAUSCH; Karl-Anton KREUZER; Arnon KATER; Francesc BOSCH; Michael DOUBEK; Panagiotis PANAGIOTIDIS; Olga KALASHNIKOVA; Federica FREZZATO; Valeria RUOCCO; Silvia ORSI; Kimia SALEK; Roberto MERLO; Alberto CAREGARI; Ilias GLOGOVITIS; Alessandro CELLINI; Francesco ANGOTZI; Andrea SERAFIN; Shuhua YI; Barbara EICHHORST; Jennifer A WOYACH; Antonio CUNEO; Paolo GHIA; Kostas STAMATOPOULOS; Livio TRENTIN; Andrea VISENTIN a Stefania BORTOLUZZI
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JOURNAL OF HEMATOLOGY & ONCOLOGY, LONDON, BMC, 2025, 1756-8722
In Chronic Lymphocytic Leukemia (CLL), t(14;19)(q32;q13), leading to the overexpression of BCL3, is found in similar to 1% of cases and is associated with an aggressive disease. In this study, leveraging a large CLL patient cohort collected thanks to an international collaboration, we investigate for the first time the circular transcriptome (circRNAome) associated with the rare t(14;19), in comparison with CLL without t(14;19) and B cells of age-matched healthy donors. We described the circRNAs commonly dysregulated in CLL, including circCSNK1G3 and circEXOC6B(3-5), which were depleted, and circZNF609 and circLPAR3, which were overexpressed in malignant cells. Of importance, we disclosed the circRNA signature of CLL with t(14;19), formed by circRNAs with expression significantly altered specifically in link with this lesion, ectopically expressed like circCDK14(3-4), circCORO1C, circCLEC2D, and circEMB, or downregulated like circCEP70(3-6). Several of these molecules were previously shown to be dysregulated or play a role in cancer, whereas most of the signature circRNAs deserve further investigation. CLL patients with high circCORO1C and circCLEC2D expression had significantly worse clinical outcomes, with shorter time to first treatment and overall survival. This study disclosed new molecular features of the aggressive CLL subtype with t(14;19).
RONCAGLIA, Eleonora; Enrico GAFFO; Giulia CALABRETTO; Moritz FUERSTENAU; Kerry A ROGERS; Panagiotis BALIAKAS; Chenghua CUI; Cecelia MILLER; Claudia HAFERLACH; Karla PLEVOVÁ; David OSCIER; Zadie DAVIS; Florence NGUYEN-KHAC; Gian Matteo RIGOLIN; Anastasia ATHANASIADOU; Fanny BARAN-MARSZAK; Alberto VALIENTE; Maria Jose TEROL; Pau ABRISQUETA; Blanca ESPINET; Anna PUIGGROS; Annalisa MARTINES; Laura BONALDI; Francesca Romana MAURO; Lydia SCARFO; Thomas CHATZIKONSTANTINOU; Eugen TAUSCH; Karl-Anton KREUZER; Arnon KATER; Francesc BOSCH; Michael DOUBEK; Panagiotis PANAGIOTIDIS; Olga KALASHNIKOVA; Federica FREZZATO; Valeria RUOCCO; Silvia ORSI; Kimia SALEK; Roberto MERLO; Alberto CAREGARI; Ilias GLOGOVITIS; Alessandro CELLINI; Francesco ANGOTZI; Andrea SERAFIN; Shuhua YI; Barbara EICHHORST; Jennifer A WOYACH; Antonio CUNEO; Paolo GHIA; Kostas STAMATOPOULOS; Livio TRENTIN; Andrea VISENTIN a Stefania BORTOLUZZI. Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. JOURNAL OF HEMATOLOGY & ONCOLOGY. LONDON: BMC, 2025, roč. 18, č. 1, s. 1-8. ISSN 1756-8722. Dostupné z: https://doi.org/10.1186/s13045-025-01725-y.
@article{2511228, author = {Roncaglia, Eleonora and Gaffo, Enrico and Calabretto, Giulia and Fuerstenau, Moritz and Rogers, Kerry A and Baliakas, Panagiotis and Cui, Chenghua and Miller, Cecelia and Haferlach, Claudia and Plevová, Karla and Oscier, David and Davis, Zadie and NguyenandKhac, Florence and Rigolin, Gian Matteo and Athanasiadou, Anastasia and BaranandMarszak, Fanny and Valiente, Alberto and Terol, Maria Jose and Abrisqueta, Pau and Espinet, Blanca and Puiggros, Anna and Martines, Annalisa and Bonaldi, Laura and Mauro, Francesca Romana and Scarfo, Lydia and Chatzikonstantinou, Thomas and Tausch, Eugen and Kreuzer, KarlandAnton and Kater, Arnon and Bosch, Francesc and Doubek, Michael and Panagiotidis, Panagiotis and Kalashnikova, Olga and Frezzato, Federica and Ruocco, Valeria and Orsi, Silvia and Salek, Kimia and Merlo, Roberto and Caregari, Alberto and Glogovitis, Ilias and Cellini, Alessandro and Angotzi, Francesco and Serafin, Andrea and Yi, Shuhua and Eichhorst, Barbara and Woyach, Jennifer A and Cuneo, Antonio and Ghia, Paolo and Stamatopoulos, Kostas and Trentin, Livio and Visentin, Andrea and Bortoluzzi, Stefania}, article_location = {LONDON}, article_number = {1}, doi = {https://doi.org/10.1186/s13045-025-01725-y}, keywords = {CLL; T(14;19); Circular RNA; BCL3}, language = {eng}, issn = {1756-8722}, journal = {JOURNAL OF HEMATOLOGY & ONCOLOGY}, title = {Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study}, url = {https://jhoonline.biomedcentral.com/articles/10.1186/s13045-025-01725-y}, volume = {18}, year = {2025} }
TY - JOUR ID - 2511228 AU - Roncaglia, Eleonora - Gaffo, Enrico - Calabretto, Giulia - Fuerstenau, Moritz - Rogers, Kerry A - Baliakas, Panagiotis - Cui, Chenghua - Miller, Cecelia - Haferlach, Claudia - Plevová, Karla - Oscier, David - Davis, Zadie - Nguyen-Khac, Florence - Rigolin, Gian Matteo - Athanasiadou, Anastasia - Baran-Marszak, Fanny - Valiente, Alberto - Terol, Maria Jose - Abrisqueta, Pau - Espinet, Blanca - Puiggros, Anna - Martines, Annalisa - Bonaldi, Laura - Mauro, Francesca Romana - Scarfo, Lydia - Chatzikonstantinou, Thomas - Tausch, Eugen - Kreuzer, Karl-Anton - Kater, Arnon - Bosch, Francesc - Doubek, Michael - Panagiotidis, Panagiotis - Kalashnikova, Olga - Frezzato, Federica - Ruocco, Valeria - Orsi, Silvia - Salek, Kimia - Merlo, Roberto - Caregari, Alberto - Glogovitis, Ilias - Cellini, Alessandro - Angotzi, Francesco - Serafin, Andrea - Yi, Shuhua - Eichhorst, Barbara - Woyach, Jennifer A - Cuneo, Antonio - Ghia, Paolo - Stamatopoulos, Kostas - Trentin, Livio - Visentin, Andrea - Bortoluzzi, Stefania PY - 2025 TI - Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study JF - JOURNAL OF HEMATOLOGY & ONCOLOGY VL - 18 IS - 1 SP - 1-8 EP - 1-8 PB - BMC SN - 17568722 KW - CLL KW - T(14;19) KW - Circular RNA KW - BCL3 UR - https://jhoonline.biomedcentral.com/articles/10.1186/s13045-025-01725-y N2 - In Chronic Lymphocytic Leukemia (CLL), t(14;19)(q32;q13), leading to the overexpression of BCL3, is found in similar to 1% of cases and is associated with an aggressive disease. In this study, leveraging a large CLL patient cohort collected thanks to an international collaboration, we investigate for the first time the circular transcriptome (circRNAome) associated with the rare t(14;19), in comparison with CLL without t(14;19) and B cells of age-matched healthy donors. We described the circRNAs commonly dysregulated in CLL, including circCSNK1G3 and circEXOC6B(3-5), which were depleted, and circZNF609 and circLPAR3, which were overexpressed in malignant cells. Of importance, we disclosed the circRNA signature of CLL with t(14;19), formed by circRNAs with expression significantly altered specifically in link with this lesion, ectopically expressed like circCDK14(3-4), circCORO1C, circCLEC2D, and circEMB, or downregulated like circCEP70(3-6). Several of these molecules were previously shown to be dysregulated or play a role in cancer, whereas most of the signature circRNAs deserve further investigation. CLL patients with high circCORO1C and circCLEC2D expression had significantly worse clinical outcomes, with shorter time to first treatment and overall survival. This study disclosed new molecular features of the aggressive CLL subtype with t(14;19). ER -
RONCAGLIA, Eleonora; Enrico GAFFO; Giulia CALABRETTO; Moritz FUERSTENAU; Kerry A ROGERS; Panagiotis BALIAKAS; Chenghua CUI; Cecelia MILLER; Claudia HAFERLACH; Karla PLEVOVÁ; David OSCIER; Zadie DAVIS; Florence NGUYEN-KHAC; Gian Matteo RIGOLIN; Anastasia ATHANASIADOU; Fanny BARAN-MARSZAK; Alberto VALIENTE; Maria Jose TEROL; Pau ABRISQUETA; Blanca ESPINET; Anna PUIGGROS; Annalisa MARTINES; Laura BONALDI; Francesca Romana MAURO; Lydia SCARFO; Thomas CHATZIKONSTANTINOU; Eugen TAUSCH; Karl-Anton KREUZER; Arnon KATER; Francesc BOSCH; Michael DOUBEK; Panagiotis PANAGIOTIDIS; Olga KALASHNIKOVA; Federica FREZZATO; Valeria RUOCCO; Silvia ORSI; Kimia SALEK; Roberto MERLO; Alberto CAREGARI; Ilias GLOGOVITIS; Alessandro CELLINI; Francesco ANGOTZI; Andrea SERAFIN; Shuhua YI; Barbara EICHHORST; Jennifer A WOYACH; Antonio CUNEO; Paolo GHIA; Kostas STAMATOPOULOS; Livio TRENTIN; Andrea VISENTIN a Stefania BORTOLUZZI. Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. \textit{JOURNAL OF HEMATOLOGY \&{} ONCOLOGY}. LONDON: BMC, 2025, roč.~18, č.~1, s.~1-8. ISSN~1756-8722. Dostupné z: https://doi.org/10.1186/s13045-025-01725-y.