Secondary target organs exhibit differential ability to clear
cadmium after cadmium oxide nanoparticle inhalation

J 2025

Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation

DUMKOVÁ, Jana; Naděžda VAŠKOVICOVÁ; Daniela KRISTEKOVÁ; Lucie VRLÍKOVÁ; Anna FARUZELOVA et al.

Základní údaje

Originální název

Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation

Autoři

Vydání

Journal of Hazardous Materials, Amsterdam, Elsevier Science BV. 2025, 0304-3894

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20601 Medical engineering

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 11.300 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cadmium oxide nanoparticles; Clearance; Electron microscopy analysis; Toxicity; Inhalation; Lung; Liver; Kidney

Štítky

14110517, 14313010, 14314010

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 12. 2025 13:25, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Inhaled cadmium oxide nanoparticles (CdONPs) represent an underrecognized environmental and occupational hazard because of their potential for systemic bioaccumulation and organ-specific toxicity. In this study, mice were exposed to subchronic inhalation of CdONPs, and cadmium distribution, clearance, and tissue responses were assessed over a 21-day recovery period using atomic absorption spectrometry, laser ablation inductively coupled plasma mass spectrometry, histopathology, and gene expression analysis. Cadmium accumulated predominantly in the lungs, where clearance was slow and accompanied by persistent inflammation and foam cell formation. The intestines exhibited efficient cadmium reduction, likely due to high epithelial turnover, while the liver showed minimal accumulation and no overt damage. By contrast, the kidneys retained cadmium pri-marily in the cortex, with partial clearance and ultrastructural changes, including mitochondrial disorganization and lipid accumulation. Bone tissues demonstrated differential retention: jaw bones effectively cleared cadmium, whereas femurs showed sustained or increased levels, suggesting redistribution from other organs. Gene expression analysis revealed moderate but consistent upregulation of Abca1, Apoe, and Ptch1 in the kidneys of clearance groups, indicating adaptations in lipid metabolism and membrane transport. These findings highlight organ-specific clearance kinetics and molecular responses to inhaled CdONPs, underscoring the need for tissue-targeted risk assessment frameworks in nanoparticle toxicology.

Návaznosti

GA24-10051S, projekt VaV

Název: Vliv nanočástic kovů na plicní tkáně a buněčné procesy přispívající k jejich efluxu z těchto tkání

Investor: Grantová agentura ČR, Vliv nanočástic kovů na plicní tkáně a buněčné procesy přispívající k jejich efluxu z těchto tkání

GA25-16166S, projekt VaV

Název: Pokročilá diagnostika mrtvice: Specifická detekce biodegradabilních nanočástic a jejich vizualizace v mozkové tkáni metodami korelativního zobrazování

Investor: Grantová agentura ČR, Pokročilá diagnostika mrtvice: Specifická detekce biodegradabilních nanočástic a jejich vizualizace v mozkové tkáni metodami korelativního zobrazování

Citovat

DUMKOVÁ, Jana; Naděžda VAŠKOVICOVÁ; Daniela KRISTEKOVÁ; Lucie VRLÍKOVÁ; Anna FARUZELOVA; Adriena JEDLIČKOVÁ; Martina TATÍČKOVÁ; Lukas ALEXA; Pavel COUFALIK; Michaela BAHELKOVÁ; Hana CIGANKOVA; Zbynek VECERA; Denisa LUSKOVA; Veronika JAKEŠOVÁ; Kamil KRUMAL; Jitka HEGROVA; Pavel PORIZKA; Jozef KAISER; Tomáš VACULOVIČ; Viktor KANICKÝ; Pavel MIKUSKA; Aleš HAMPL a Marcela BUCHTOVÁ. Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2025, roč. 496, September 2025, s. 1-24. ISSN 0304-3894. Dostupné z: https://doi.org/10.1016/j.jhazmat.2025.139181.

@article{2511425,
   author = {Dumková, Jana and Vaškovicová, Naděžda and Kristeková, Daniela and Vrlíková, Lucie and Faruzelova, Anna and Jedličková, Adriena and Tatíčková, Martina and Alexa, Lukas and Coufalik, Pavel and Bahelková, Michaela and Cigankova, Hana and Vecera, Zbynek and Luskova, Denisa and Jakešová, Veronika and Krumal, Kamil and Hegrova, Jitka and Porizka, Pavel and Kaiser, Jozef and Vaculovič, Tomáš and Kanický, Viktor and Mikuska, Pavel and Hampl, Aleš and Buchtová, Marcela},
   article_location = {Amsterdam},
   article_number = {September 2025},
   doi = {https://doi.org/10.1016/j.jhazmat.2025.139181},
   keywords = {Cadmium oxide nanoparticles; Clearance; Electron microscopy analysis; Toxicity; Inhalation; Lung; Liver; Kidney},
   language = {eng},
   issn = {0304-3894},
   journal = {Journal of Hazardous Materials},
   title = {Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation},
   url = {https://www.sciencedirect.com/science/article/pii/S0304389425020977?via%3Dihub},
   volume = {496},
   year = {2025}
}

TY  - JOUR
ID  - 2511425
AU  - Dumková, Jana - Vaškovicová, Naděžda - Kristeková, Daniela - Vrlíková, Lucie - Faruzelova, Anna - Jedličková, Adriena - Tatíčková, Martina - Alexa, Lukas - Coufalik, Pavel - Bahelková, Michaela - Cigankova, Hana - Vecera, Zbynek - Luskova, Denisa - Jakešová, Veronika - Krumal, Kamil - Hegrova, Jitka - Porizka, Pavel - Kaiser, Jozef - Vaculovič, Tomáš - Kanický, Viktor - Mikuska, Pavel - Hampl, Aleš - Buchtová, Marcela
PY  - 2025
TI  - Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation
JF  - Journal of Hazardous Materials
VL  - 496
IS  - September 2025
SP  - 1-24
EP  - 1-24
PB  - Elsevier Science BV.
SN  - 03043894
KW  - Cadmium oxide nanoparticles
KW  - Clearance
KW  - Electron microscopy analysis
KW  - Toxicity
KW  - Inhalation
KW  - Lung
KW  - Liver
KW  - Kidney
UR  - https://www.sciencedirect.com/science/article/pii/S0304389425020977?via%3Dihub
N2  - Inhaled cadmium oxide nanoparticles (CdONPs) represent an underrecognized environmental and occupational hazard because of their potential for systemic bioaccumulation and organ-specific toxicity. In this study, mice were exposed to subchronic inhalation of CdONPs, and cadmium distribution, clearance, and tissue responses were assessed over a 21-day recovery period using atomic absorption spectrometry, laser ablation inductively coupled plasma mass spectrometry, histopathology, and gene expression analysis. Cadmium accumulated predominantly in the lungs, where clearance was slow and accompanied by persistent inflammation and foam cell formation. The intestines exhibited efficient cadmium reduction, likely due to high epithelial turnover, while the liver showed minimal accumulation and no overt damage. By contrast, the kidneys retained cadmium pri-marily in the cortex, with partial clearance and ultrastructural changes, including mitochondrial disorganization and lipid accumulation. Bone tissues demonstrated differential retention: jaw bones effectively cleared cadmium, whereas femurs showed sustained or increased levels, suggesting redistribution from other organs. Gene expression analysis revealed moderate but consistent upregulation of Abca1, Apoe, and Ptch1 in the kidneys of clearance groups, indicating adaptations in lipid metabolism and membrane transport. These findings highlight organ-specific clearance kinetics and molecular responses to inhaled CdONPs, underscoring the need for tissue-targeted risk assessment frameworks in nanoparticle toxicology.
ER  -

DUMKOVÁ, Jana; Naděžda VAŠKOVICOVÁ; Daniela KRISTEKOVÁ; Lucie VRLÍKOVÁ; Anna FARUZELOVA; Adriena JEDLIČKOVÁ; Martina TATÍČKOVÁ; Lukas ALEXA; Pavel COUFALIK; Michaela BAHELKOVÁ; Hana CIGANKOVA; Zbynek VECERA; Denisa LUSKOVA; Veronika JAKEŠOVÁ; Kamil KRUMAL; Jitka HEGROVA; Pavel PORIZKA; Jozef KAISER; Tomáš VACULOVIČ; Viktor KANICKÝ; Pavel MIKUSKA; Aleš HAMPL a Marcela BUCHTOVÁ. Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2025, roč.~496, September 2025, s.~1-24. ISSN~0304-3894. Dostupné z: https://doi.org/10.1016/j.jhazmat.2025.139181.

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