A Method for Determination of Transport Efficiency in Laser
Ablation Inductively Coupled Plasma Mass Spectrometry for
Tissue Analysis

J 2025

A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis

STRÁNÍK, Jaromír; Vilém SVOJANOVSKÝ; Julie WEISOVA; Katerina UHROVA; David CLASES et al.

Základní údaje

Originální název

A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis

Autoři

STRÁNÍK, Jaromír; Vilém SVOJANOVSKÝ; Julie WEISOVA; Katerina UHROVA; David CLASES; Antonin HLAVACEK a Jan PREISLER

Vydání

ANALYTICAL CHEMISTRY, WASHINGTON, AMER CHEMICAL SOC, 2025, 0003-2700

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.700 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

NANOPARTICLES; Ablation; Lasers; Layers; Materials; Nanoparticles

Štítky

14313010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 1. 2026 09:36, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Recent studies have demonstrated the applicability of the "single particle" mode in laser ablation-inductively coupled plasma-mass spectrometry to map and size particles simultaneously. The transport efficiency (TE) is an important parameter in this configuration and affects the detection of individual nanoparticles, reliability of nanoparticle characterization, and related applications. This study introduces a novel method for the precise determination of TE, based on counting upconversion nanoparticles from gels characterized by fluorescent microscopy. The method was found to be most suitable for the 2940-nm laser ablation system, achieving virtually quantitative nanoparticle desorption, with TE primarily governed by ablation cell design and aerosol transport efficiency. With the 213-nm laser, attention had to be paid to incomplete desorption and possible nanoparticle redeposition at low laser fluences to avoid variability in TE measurements. Finally, use of the 193-nm laser-induced nanoparticle disintegration, resulting in elevated baseline noise and lower sensitivity, which prevented the use of this approach for the determination of TE. This study highlights the versatility of the proposed method, while also identifying its limitations, in terms of wavelength and fluence.

Návaznosti

GA24-10924S, projekt VaV

Název: Digitální multiplexní zobrazovací hmotnostní spektrometrie

Investor: Grantová agentura ČR, Digitální multiplexní zobrazovací hmotnostní spektrometrie

Citovat

STRÁNÍK, Jaromír; Vilém SVOJANOVSKÝ; Julie WEISOVA; Katerina UHROVA; David CLASES; Antonin HLAVACEK a Jan PREISLER. A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis. ANALYTICAL CHEMISTRY. WASHINGTON: AMER CHEMICAL SOC, 2025, roč. 97, č. 25, s. 12940-12946. ISSN 0003-2700. Dostupné z: https://doi.org/10.1021/acs.analchem.5c01306.

@article{2516709,
   author = {Stráník, Jaromír and Svojanovský, Vilém and Weisova, Julie and Uhrova, Katerina and Clases, David and Hlavacek, Antonin and Preisler, Jan},
   article_location = {WASHINGTON},
   article_number = {25},
   doi = {https://doi.org/10.1021/acs.analchem.5c01306},
   keywords = {NANOPARTICLES; Ablation; Lasers; Layers; Materials; Nanoparticles},
   language = {eng},
   issn = {0003-2700},
   journal = {ANALYTICAL CHEMISTRY},
   title = {A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis},
   url = {https://pubs.acs.org/doi/10.1021/acs.analchem.5c01306},
   volume = {97},
   year = {2025}
}

TY  - JOUR
ID  - 2516709
AU  - Stráník, Jaromír - Svojanovský, Vilém - Weisova, Julie - Uhrova, Katerina - Clases, David - Hlavacek, Antonin - Preisler, Jan
PY  - 2025
TI  - A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis
JF  - ANALYTICAL CHEMISTRY
VL  - 97
IS  - 25
SP  - 12940-12946
EP  - 12940-12946
PB  - AMER CHEMICAL SOC
SN  - 00032700
KW  - NANOPARTICLES
KW  - Ablation
KW  - Lasers
KW  - Layers
KW  - Materials
KW  - Nanoparticles
UR  - https://pubs.acs.org/doi/10.1021/acs.analchem.5c01306
N2  - Recent studies have demonstrated the applicability of the "single particle" mode in laser ablation-inductively coupled plasma-mass spectrometry to map and size particles simultaneously. The transport efficiency (TE) is an important parameter in this configuration and affects the detection of individual nanoparticles, reliability of nanoparticle characterization, and related applications. This study introduces a novel method for the precise determination of TE, based on counting upconversion nanoparticles from gels characterized by fluorescent microscopy. The method was found to be most suitable for the 2940-nm laser ablation system, achieving virtually quantitative nanoparticle desorption, with TE primarily governed by ablation cell design and aerosol transport efficiency. With the 213-nm laser, attention had to be paid to incomplete desorption and possible nanoparticle redeposition at low laser fluences to avoid variability in TE measurements. Finally, use of the 193-nm laser-induced nanoparticle disintegration, resulting in elevated baseline noise and lower sensitivity, which prevented the use of this approach for the determination of TE. This study highlights the versatility of the proposed method, while also identifying its limitations, in terms of wavelength and fluence.
ER  -

STRÁNÍK, Jaromír; Vilém SVOJANOVSKÝ; Julie WEISOVA; Katerina UHROVA; David CLASES; Antonin HLAVACEK a Jan PREISLER. A Method for Determination of Transport Efficiency in Laser Ablation Inductively Coupled Plasma Mass Spectrometry for Tissue Analysis. \textit{ANALYTICAL CHEMISTRY}. WASHINGTON: AMER CHEMICAL SOC, 2025, roč.~97, č.~25, s.~12940-12946. ISSN~0003-2700. Dostupné z: https://doi.org/10.1021/acs.analchem.5c01306.

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