Mechanics and Mechanisms of Mouse Incisor Growth and Repair

k 2025

Mechanics and Mechanisms of Mouse Incisor Growth and Repair

GONZÁLEZ LÓPEZ, Marcos; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ; Sarah KNAUTH et al.

Základní údaje

Originální název

Mechanics and Mechanisms of Mouse Incisor Growth and Repair

Autoři

Vydání

Visegrád Group Society for Developmental Biology Meeting 2025, 2025

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10605 Developmental biology

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00144439

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Tooth regeneration; Stem cells; Growth dynamics; Niche; BEE-ST

Změněno: 15. 9. 2025 10:09, Mgr. Tereza Slaměníková

Anotace

V originále

Continuously growing mouse incisors, have for decades served as a model system for investigating the mechanisms of regeneration and studying the stem cell niche. It has been shown that the growth rate of these teeth does not always proceed at the same pace but can be accelerated following injury. However, the dynamics of growth acceleration, the mechanisms responsible for damage detection and the subsequent process of stem cell niche activation remains entirely unresolved. Here, we provide new insights into the dynamics of mouse incisor regeneration, both in healthy (non-damaged) tooth and after its injury. To quantify incisor growth, we have invented a new method (BEE-ST: Bones and tEEth Spatio-Temporal growth monitoring approach) that allows to monitor the growth and healing dynamics of any hard tissue on micrometre scale in both space and time. Subsequently, using an interdisciplinary approach involving mathematical modelling, single-cell RNA-sequencing, spatial transcriptomics and lineage tracing, we reveal new mechanisms responsible for the detection of injury and we provide new insights into the mechanical, cellular and molecular mechanisms responsible for the acceleration of tooth growth. Our research approaches the study of continuously growing teeth from a new interdisciplinary perspective. These results shed light on the large complexity of biological and mechanical processes standing behind the regulation of continuous tooth growth and suggest a new insight into stem cell niche activation from a more general perspective.

Návaznosti

GA23-06160S, projekt VaV

Název: Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Investor: Grantová agentura ČR, Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Citovat

GONZÁLEZ LÓPEZ, Marcos; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ; Sarah KNAUTH; Ema GROFOVÁ; Michaela VODIČKOVÁ; Marcela BUCHTOVÁ; Václav SADÍLEK; Julian PETERSEN; Miroslav VOŘECHOVSKÝ a Jan KŘIVÁNEK. Mechanics and Mechanisms of Mouse Incisor Growth and Repair. In Visegrád Group Society for Developmental Biology Meeting 2025. 2025.

@proceedings{2518480,
   author = {González López, Marcos and Kavková, Michaela and Lavický, Josef and Hutečková, Barbora and Knauth, Sarah and Grofová, Ema and Vodičková, Michaela and Buchtová, Marcela and Sadílek, Václav and Petersen, Julian and Vořechovský, Miroslav and Křivánek, Jan},
   booktitle = {Visegrád Group Society for Developmental Biology Meeting 2025},
   keywords = {Tooth regeneration; Stem cells; Growth dynamics; Niche; BEE-ST},
   language = {eng},
   title = {Mechanics and Mechanisms of Mouse Incisor Growth and Repair},
   url = {https://v4sdb2025.img.cas.cz/},
   year = {2025}
}

TY  - CONF
ID  - 2518480
AU  - González López, Marcos - Kavková, Michaela - Lavický, Josef - Hutečková, Barbora - Knauth, Sarah - Grofová, Ema - Vodičková, Michaela - Buchtová, Marcela - Sadílek, Václav - Petersen, Julian - Vořechovský, Miroslav - Křivánek, Jan
PY  - 2025
TI  - Mechanics and Mechanisms of Mouse Incisor Growth and Repair
KW  - Tooth regeneration
KW  - Stem cells
KW  - Growth dynamics
KW  - Niche
KW  - BEE-ST
UR  - https://v4sdb2025.img.cas.cz/
N2  - Continuously growing mouse incisors, have for decades served as a model system for investigating the mechanisms of regeneration and studying the stem cell niche. It has been shown that the growth rate of these teeth does not always proceed at the same pace but can be accelerated following injury. However, the dynamics of growth acceleration, the mechanisms responsible for damage detection and the subsequent process of stem cell niche activation remains entirely unresolved. Here, we provide new insights into the dynamics of mouse incisor regeneration, both in healthy (non-damaged) tooth and after its injury. To quantify incisor growth, we have invented a new method (BEE-ST: Bones and tEEth Spatio-Temporal growth monitoring approach) that allows to monitor the growth and healing dynamics of any hard tissue on micrometre scale in both space and time. Subsequently, using an interdisciplinary approach involving mathematical modelling, single-cell RNA-sequencing, spatial transcriptomics and lineage tracing, we reveal new mechanisms responsible for the detection of injury and we provide new insights into the mechanical, cellular and molecular mechanisms responsible for the acceleration of tooth growth. Our research approaches the study of continuously growing teeth from a new interdisciplinary perspective. These results shed light on the large complexity of biological and mechanical processes standing behind the regulation of continuous tooth growth and suggest a new insight into stem cell niche activation from a more general perspective.
ER  -

GONZÁLEZ LÓPEZ, Marcos; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ; Sarah KNAUTH; Ema GROFOVÁ; Michaela VODIČKOVÁ; Marcela BUCHTOVÁ; Václav SADÍLEK; Julian PETERSEN; Miroslav VOŘECHOVSKÝ a Jan KŘIVÁNEK. Mechanics and Mechanisms of Mouse Incisor Growth and Repair. In \textit{Visegrád Group Society for Developmental Biology Meeting 2025}. 2025.

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