Smart regrowth of mouse incisor: Impacts of incisor damage on
growth and morphology

a 2025

Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

AZAM, Maryam; Marcos GONZÁLEZ LÓPEZ; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ et al.

Základní údaje

Originální název

Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Autoři

Vydání

Visegrád Group Society for Developmental Biology Meeting 2025, 2025

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10605 Developmental biology

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Změněno: 15. 9. 2025 14:42, Mgr. Tereza Slaměníková

Anotace

V originále

Mechanosensation and mechanotransduction are critical processes in various biological systems, underpinning development, regeneration, and tissue repair. Mice possess continuously growing incisors that renew throughout their lifespan, offering an exceptional model for studying tissue homeostasis and regeneration. Despite the known importance of stem cell activity in the dental pulp for incisor renewal, the mechanisms controlling this process, particularly in response to mechanical stimuli or injury, remain unclear. In this study, we aimed to elucidate how mechanical stimuli or injury influence normal incisor growth using a tooth-clipping injury model. Furthermore, we examined whether clipping injury triggers phenotypical changes and alters the mechanical properties of the tooth and the surrounding alveolar bone. Finally, at the cellular level, we analyzed signaling adaptations in tooth-forming cells and elucidated changes in cell proliferation dynamics within the stem cell niche. Our findings reveal that incisor shortening induces complex phenotypical changes, influencing both cellular behavior and molecular signaling. The insights from this study shed light on how mechanical cues modulate structural and functional dynamics of incisor regeneration, providing a deeper understanding of the role of mechanosensing in tooth renewal and adaptation.

Návaznosti

GA25-18087S, projekt VaV

Název: Buněčná podstata hojení zubu

Investor: Grantová agentura ČR, Buněčná podstata hojení zubu

Citovat

AZAM, Maryam; Marcos GONZÁLEZ LÓPEZ; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ; Sarah KNAUTH; Ema GROFOVÁ; Michaela VODIČKOVÁ; Marcela BUCHTOVÁ; Václav SADÍLEK; Julian PETERSEN; Miroslav VOŘECHOVSKÝ a Jan KŘIVÁNEK. Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology. In Visegrád Group Society for Developmental Biology Meeting 2025. 2025.

@proceedings{2518607,
   author = {Azam, Maryam and González López, Marcos and Kavková, Michaela and Lavický, Josef and Hutečková, Barbora and Knauth, Sarah and Grofová, Ema and Vodičková, Michaela and Buchtová, Marcela and Sadílek, Václav and Petersen, Julian and Vořechovský, Miroslav and Křivánek, Jan},
   booktitle = {Visegrád Group Society for Developmental Biology Meeting 2025},
   language = {eng},
   title = {Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology},
   year = {2025}
}

TY  - CONF
ID  - 2518607
AU  - Azam, Maryam - González López, Marcos - Kavková, Michaela - Lavický, Josef - Hutečková, Barbora - Knauth, Sarah - Grofová, Ema - Vodičková, Michaela - Buchtová, Marcela - Sadílek, Václav - Petersen, Julian - Vořechovský, Miroslav - Křivánek, Jan
PY  - 2025
TI  - Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology
N2  - Mechanosensation and mechanotransduction are critical processes in various biological systems, underpinning development, regeneration, and tissue repair. Mice possess continuously growing incisors that renew throughout their lifespan, offering an exceptional model for studying tissue homeostasis and regeneration. Despite the known importance of stem cell activity in the dental pulp for incisor renewal, the mechanisms controlling this process, particularly in response to mechanical stimuli or injury, remain unclear. In this study, we aimed to elucidate how mechanical stimuli or injury influence normal incisor growth using a tooth-clipping injury model. Furthermore, we examined whether clipping injury triggers phenotypical changes and alters the mechanical properties of the tooth and the surrounding alveolar bone. Finally, at the cellular level, we analyzed signaling adaptations in tooth-forming cells and elucidated changes in cell proliferation dynamics within the stem cell niche. Our findings reveal that incisor shortening induces complex phenotypical changes, influencing both cellular behavior and molecular signaling. The insights from this study shed light on how mechanical cues modulate structural and functional dynamics of incisor regeneration, providing a deeper understanding of the role of mechanosensing in tooth renewal and adaptation.
ER  -

AZAM, Maryam; Marcos GONZÁLEZ LÓPEZ; Michaela KAVKOVÁ; Josef LAVICKÝ; Barbora HUTEČKOVÁ; Sarah KNAUTH; Ema GROFOVÁ; Michaela VODIČKOVÁ; Marcela BUCHTOVÁ; Václav SADÍLEK; Julian PETERSEN; Miroslav VOŘECHOVSKÝ a Jan KŘIVÁNEK. Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology. In \textit{Visegrád Group Society for Developmental Biology Meeting 2025}. 2025.

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