Tailored biopolymer capsules for colon-specific drug delivery:
A 3D printing perspective

J 2025

Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective

MUSELÍK, Jan; Alena KOMERSOVA; Jan ELBL; Roman SVOBODA; Kevin MATZICK et al.

Základní údaje

Originální název

Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective

Autoři

MUSELÍK, Jan ; Alena KOMERSOVA; Jan ELBL ; Roman SVOBODA; Kevin MATZICK; Jana MACHACKOVA; Marie NEVYHOSTENA; Zuzana KREPELKOVA; Jaroslav NOVOTNY a Aleš FRANC

Vydání

JOURNAL OF PHARMACEUTICAL SCIENCES, NEW YORK, ELSEVIER SCIENCE INC, 2025, 0022-3549

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.800 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00144463

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

3D printed capsules; Colonic drug delivery system; Colitis; Personalized medicine; Microbiota-triggered release mechanism; Pectin

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2026 13:40, Mgr. Irena Doubková

Anotace

V originále

The present study aims to develop capsules employing hot melt extrusion (HME) and fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a colon drug delivery system (CDDS) based on multiple release mechanisms. In the study, 3D printed hydroxypropylmethylcellulose (HPMC) based capsules containing polysaccharides (alginate, chitosan pectin from citrus and pectin from apple) were used to provide a time-triggered and microbiota-triggered release mechanism. Thirteen capsule compositions were tested, and physico-chemical properties, disintegration time, dissolution characteristic (lag time) and 50 days accelerated stability were assessed. In addition, an enteric coating by Eudragit S was tested to enhance protection against the gastric environment. Disintegration time of the capsule under in vivo conditions was verified in healthy volunteers by oral administration of the caffeine-loaded capsule and determination of the first-appearance time of caffeine in the saliva. Furthermore, in vivo monitoring of the transition time in piglets was performed by X-ray examination after oral administration of BaSO4-loaded capsules. Optimal capsule composition was identified as HPMC and pectin from citrus in 80:20 wt% ratio. Printed capsules showed suitable physico-chemical properties, lag time and stability. Minimal drug release in the upper gastrointestinal tract ( 5 %) for the first 8-10 h was ensured by both coated and uncoated capsules. In addition, as demonstrated by the in vivo transition time monitoring assay, with accelerated passage of the capsule through the gastrointestinal tract, degradation is significantly accelerated ( 4 h) by a microbiota-triggered mechanism, effectively targeting the colon. Using 3D printing, a colonic-specific drug delivery system was prepared that could potentially be suitable for treating patients with various intestinal physiological conditions.

Návaznosti

GA22-03187S, projekt VaV

Název: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic (Akronym: 22-03187S)

Investor: Grantová agentura ČR, Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spektrem biologické aktivity k terapii sliznic

Citovat

MUSELÍK, Jan; Alena KOMERSOVA; Jan ELBL; Roman SVOBODA; Kevin MATZICK; Jana MACHACKOVA; Marie NEVYHOSTENA; Zuzana KREPELKOVA; Jaroslav NOVOTNY a Aleš FRANC. Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective. JOURNAL OF PHARMACEUTICAL SCIENCES. NEW YORK: ELSEVIER SCIENCE INC, 2025, roč. 114, č. 7, s. 1-13. ISSN 0022-3549. Dostupné z: https://doi.org/10.1016/j.xphs.2025.103815.

@article{2520798,
   author = {Muselík, Jan and Komersova, Alena and Elbl, Jan and Svoboda, Roman and Matzick, Kevin and Machackova, Jana and Nevyhostena, Marie and Krepelkova, Zuzana and Novotny, Jaroslav and Franc, Aleš},
   article_location = {NEW YORK},
   article_number = {7},
   doi = {https://doi.org/10.1016/j.xphs.2025.103815},
   keywords = {3D printed capsules; Colonic drug delivery system; Colitis; Personalized medicine; Microbiota-triggered release mechanism; Pectin},
   language = {eng},
   issn = {0022-3549},
   journal = {JOURNAL OF PHARMACEUTICAL SCIENCES},
   title = {Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S0022354925002680},
   volume = {114},
   year = {2025}
}

TY  - JOUR
ID  - 2520798
AU  - Muselík, Jan - Komersova, Alena - Elbl, Jan - Svoboda, Roman - Matzick, Kevin - Machackova, Jana - Nevyhostena, Marie - Krepelkova, Zuzana - Novotny, Jaroslav - Franc, Aleš
PY  - 2025
TI  - Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective
JF  - JOURNAL OF PHARMACEUTICAL SCIENCES
VL  - 114
IS  - 7
SP  - 1-13
EP  - 1-13
PB  - ELSEVIER SCIENCE INC
SN  - 00223549
KW  - 3D printed capsules
KW  - Colonic drug delivery system
KW  - Colitis
KW  - Personalized medicine
KW  - Microbiota-triggered release mechanism
KW  - Pectin
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0022354925002680
N2  - The present study aims to develop capsules employing hot melt extrusion (HME) and fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a colon drug delivery system (CDDS) based on multiple release mechanisms. In the study, 3D printed hydroxypropylmethylcellulose (HPMC) based capsules containing polysaccharides (alginate, chitosan pectin from citrus and pectin from apple) were used to provide a time-triggered and microbiota-triggered release mechanism. Thirteen capsule compositions were tested, and physico-chemical properties, disintegration time, dissolution characteristic (lag time) and 50 days accelerated stability were assessed. In addition, an enteric coating by Eudragit S was tested to enhance protection against the gastric environment. Disintegration time of the capsule under in vivo conditions was verified in healthy volunteers by oral administration of the caffeine-loaded capsule and determination of the first-appearance time of caffeine in the saliva. Furthermore, in vivo monitoring of the transition time in piglets was performed by X-ray examination after oral administration of BaSO4-loaded capsules. Optimal capsule composition was identified as HPMC and pectin from citrus in 80:20 wt% ratio. Printed capsules showed suitable physico-chemical properties, lag time and stability. Minimal drug release in the upper gastrointestinal tract ( 5 %) for the first 8-10 h was ensured by both coated and uncoated capsules. In addition, as demonstrated by the in vivo transition time monitoring assay, with accelerated passage of the capsule through the gastrointestinal tract, degradation is significantly accelerated ( 4 h) by a microbiota-triggered mechanism, effectively targeting the colon. Using 3D printing, a colonic-specific drug delivery system was prepared that could potentially be suitable for treating patients with various intestinal physiological conditions.
ER  -

MUSELÍK, Jan; Alena KOMERSOVA; Jan ELBL; Roman SVOBODA; Kevin MATZICK; Jana MACHACKOVA; Marie NEVYHOSTENA; Zuzana KREPELKOVA; Jaroslav NOVOTNY a Aleš FRANC. Tailored biopolymer capsules for colon-specific drug delivery: A 3D printing perspective. \textit{JOURNAL OF PHARMACEUTICAL SCIENCES}. NEW YORK: ELSEVIER SCIENCE INC, 2025, roč.~114, č.~7, s.~1-13. ISSN~0022-3549. Dostupné z: https://doi.org/10.1016/j.xphs.2025.103815.

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