Polybrominated diphenyl ethers (PBDEs), polychlorinated
biphenyls (PCBs), organochlorine pesticides (OCPs) in human
breast milk from Colombia: A probabilistic risk assessment
approach

J 2023

Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach

TORRES-MORENO, Adriana C.; Karen MEJIA-GRAU; Laura PUENTE-DELACRUZ; Garry Paul CODLING; Aída Luz VILLA et al.

Základní údaje

Originální název

Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach

Autoři

TORRES-MORENO, Adriana C.; Karen MEJIA-GRAU; Laura PUENTE-DELACRUZ; Garry Paul CODLING; Aída Luz VILLA; Oscar RÍOS-MARQUEZ; Laura PATEQUIVA-CHAUTA; Martha Isabel COBO a Boris JOHNSON-RESTREPO

Vydání

Chemosphere, Elsevier Ltd. 2023, 0045-6535

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00142096

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.chemosphere.2023.139597

EID Scopus

2-s2.0-85166556520

Klíčová slova anglicky

breast milk; exposure assessment; Hazard quotient; Monte Carlo simulation; OCPs; Organochlorine pesticides; PBDEs; PCBs; Polybrominated diphenyl ethers; Polychlorinated biphenyls; toxic equivalent

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 9. 2025 11:49, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) are ubiquitous environmental contaminants. They were produced in relatively large volumes in the last century and are now subject to long-term monitoring and regulated under the United Nations Stockholm Convention (SC) on persistent organic pollutants (POPs). Though restricted, human exposure is still a concern and in some regions of the globe the information on the health risk is limited. Sixty breast milk samples from nursing mothers were collected between 2014 and 2015, residing in Bogota, Cartagena, and Medellin, which are industrialized cities in Colombia. This is the first comprehensive study to determine the concentrations in breast milk of PBDEs (n = 7), PCBs (n = 29), and OCPs (n = 28) in Colombia. The detection frequency of POPs, including BDE-47, CB-138, CB-153, CB-156, and CB-180, as well as several OCPs such as chloroneb, aldrins, HCHs, DDTs, and heptachlor, was found to be 100% in all samples tested. The mean concentrations of the analyzed legacy POPs were ∑3DDTs (423 ng/g lw) > chloroneb (50.1 ng/g lw) > ∑2permetrins (17.5 ng/g lw) > ∑2aldrins (16.7 ng/g lw) > 29 PCBs (15.04 ng/g lw) > ∑2chlordanes (CHLs) (11.2 ng/g lw) ≈ ∑3endosulfans (11.1 ng/g lw) > ∑2heptachlors (2.43 ng/g lw) > 7PBDEs (2.1 ng/g lw) > ∑4HCHs (0.58 ng/g lw). The results of this study suggest that the concentrations of DDTs were present in breast milk samples from Colombia at levels comparable to those found in previous studies conducted in other countries such as Brazil, Uruguay, Chile, and various Asian countries. The concentrations of PBDE and PCB congeners, as well as many pesticides, were found to be significantly correlated with each other. This suggests that these substances may have similar sources of exposure. The strength of the pair correlation among concentrations of POPs was assessed using Spearman's correlation coefficients, which varied from r = 0.62 for the association between BDE-47 and CB-153, to a high correlation of 0.99 for the correlation between γ-Chlordane and heptachlor. This suggests that these POPs may share similar sources, such as diet. An exposure assessment model obtained by Monte Carlo simulation showed that infants were exposed to low concentrations of POPs with exception of p,p’-DDE and Aldrin, in which 25th, 50th and 95th percentiles were greater than the threshold reference values of non-carcinogenic effects suggested by US-EPA regulations while the 90th percentile of pg TEQ/Kg-bw/day for dl-PCBs was above of the tolerable daily intake (TDI) proposed by the World Health Organization (WHO). Therefore, the health risk of infants exposed to OCPs and dl-PCBs should be exanimated continually through biomonitoring programs in the Colombian population.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

839243, interní kód MU

Název: Finding unknown endocrine disrupting compounds through target pull-down assay filtration, effect direct analysis and ultra-high resolution mass spectrometry for a comprehensive efficient workflow (Akronym: PullEd-MS)

Investor: Evropská unie, Finding unknown endocrine disrupting compounds through target pull-down assay filtration, effect direct analysis and ultra-high resolution mass spectrometry for a comprehensive efficient workflow, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

TORRES-MORENO, Adriana C.; Karen MEJIA-GRAU; Laura PUENTE-DELACRUZ; Garry Paul CODLING; Aída Luz VILLA; Oscar RÍOS-MARQUEZ; Laura PATEQUIVA-CHAUTA; Martha Isabel COBO a Boris JOHNSON-RESTREPO. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach. Chemosphere. Elsevier Ltd., 2023, roč. 339, October, s. 139597-139611. ISSN 0045-6535. Dostupné z: https://doi.org/10.1016/j.chemosphere.2023.139597.

@article{2520800,
   author = {TorresandMoreno, Adriana C. and MejiaandGrau, Karen and PuenteandDelaCruz, Laura and Codling, Garry Paul and Villa, Aída Luz and RíosandMarquez, Oscar and PatequivaandChauta, Laura and Cobo, Martha Isabel and JohnsonandRestrepo, Boris},
   article_number = {October},
   doi = {https://doi.org/10.1016/j.chemosphere.2023.139597},
   keywords = {breast milk; exposure assessment; Hazard quotient; Monte Carlo simulation; OCPs; Organochlorine pesticides; PBDEs; PCBs; Polybrominated diphenyl ethers; Polychlorinated biphenyls; toxic equivalent},
   language = {eng},
   issn = {0045-6535},
   journal = {Chemosphere},
   title = {Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach},
   url = {https://www.sciencedirect.com/science/article/pii/S0045653523018647},
   volume = {339},
   year = {2023}
}

TY  - JOUR
ID  - 2520800
AU  - Torres-Moreno, Adriana C. - Mejia-Grau, Karen - Puente-DelaCruz, Laura - Codling, Garry Paul - Villa, Aída Luz - Ríos-Marquez, Oscar - Patequiva-Chauta, Laura - Cobo, Martha Isabel - Johnson-Restrepo, Boris
PY  - 2023
TI  - Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach
JF  - Chemosphere
VL  - 339
IS  - October
SP  - 139597
EP  - 139597
PB  - Elsevier Ltd.
SN  - 00456535
KW  - breast milk
KW  - exposure assessment
KW  - Hazard quotient
KW  - Monte Carlo simulation
KW  - OCPs
KW  - Organochlorine pesticides
KW  - PBDEs
KW  - PCBs
KW  - Polybrominated diphenyl ethers
KW  - Polychlorinated biphenyls
KW  - toxic equivalent
UR  - https://www.sciencedirect.com/science/article/pii/S0045653523018647
N2  - Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) are ubiquitous environmental contaminants. They were produced in relatively large volumes in the last century and are now subject to long-term monitoring and regulated under the United Nations Stockholm Convention (SC) on persistent organic pollutants (POPs). Though restricted, human exposure is still a concern and in some regions of the globe the information on the health risk is limited. Sixty breast milk samples from nursing mothers were collected between 2014 and 2015, residing in Bogota, Cartagena, and Medellin, which are industrialized cities in Colombia. This is the first comprehensive study to determine the concentrations in breast milk of PBDEs (n = 7), PCBs (n = 29), and OCPs (n = 28) in Colombia. The detection frequency of POPs, including BDE-47, CB-138, CB-153, CB-156, and CB-180, as well as several OCPs such as chloroneb, aldrins, HCHs, DDTs, and heptachlor, was found to be 100% in all samples tested. The mean concentrations of the analyzed legacy POPs were ∑3DDTs (423 ng/g lw) > chloroneb (50.1 ng/g lw) > ∑2permetrins (17.5 ng/g lw) > ∑2aldrins (16.7 ng/g lw) > 29 PCBs (15.04 ng/g lw) > ∑2chlordanes (CHLs) (11.2 ng/g lw) ≈ ∑3endosulfans (11.1 ng/g lw) > ∑2heptachlors (2.43 ng/g lw) > 7PBDEs (2.1 ng/g lw) > ∑4HCHs (0.58 ng/g lw). The results of this study suggest that the concentrations of DDTs were present in breast milk samples from Colombia at levels comparable to those found in previous studies conducted in other countries such as Brazil, Uruguay, Chile, and various Asian countries. The concentrations of PBDE and PCB congeners, as well as many pesticides, were found to be significantly correlated with each other. This suggests that these substances may have similar sources of exposure. The strength of the pair correlation among concentrations of POPs was assessed using Spearman's correlation coefficients, which varied from r = 0.62 for the association between BDE-47 and CB-153, to a high correlation of 0.99 for the correlation between γ-Chlordane and heptachlor. This suggests that these POPs may share similar sources, such as diet. An exposure assessment model obtained by Monte Carlo simulation showed that infants were exposed to low concentrations of POPs with exception of p,p’-DDE and Aldrin, in which 25th, 50th and 95th percentiles were greater than the threshold reference values of non-carcinogenic effects suggested by US-EPA regulations while the 90th percentile of pg TEQ/Kg-bw/day for dl-PCBs was above of the tolerable daily intake (TDI) proposed by the World Health Organization (WHO). Therefore, the health risk of infants exposed to OCPs and dl-PCBs should be exanimated continually through biomonitoring programs in the Colombian population.
ER  -

TORRES-MORENO, Adriana C.; Karen MEJIA-GRAU; Laura PUENTE-DELACRUZ; Garry Paul CODLING; Aída Luz VILLA; Oscar RÍOS-MARQUEZ; Laura PATEQUIVA-CHAUTA; Martha Isabel COBO a Boris JOHNSON-RESTREPO. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach. \textit{Chemosphere}. Elsevier Ltd., 2023, roč.~339, October, s.~139597-139611. ISSN~0045-6535. Dostupné z: https://doi.org/10.1016/j.chemosphere.2023.139597.

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