Enhanced toxicity of bisphenol F compared to its predecessor
bisphenol A in rainbow trout (Oncorhynchus mykiss) during a
six-week feeding trial

J 2025

Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial

STOKLASOVA, Vendula; Premysl MIKULA; Aneta HOLLEROVA; Petr MARSALEK; Nikola PESKOVA et al.

Základní údaje

Originální název

Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial

Autoři

STOKLASOVA, Vendula; Premysl MIKULA; Aneta HOLLEROVA; Petr MARSALEK; Nikola PESKOVA; Aleš FRANC; Lucie SEDLÁČKOVÁ ; Frantisek TICHY; Eva POSTULKOVA; Jan MARES; Zdenka SVOBODOVA a Jana BLAHOVA

Vydání

AQUATIC TOXICOLOGY, AMSTERDAM, ELSEVIER, 2025, 0166-445X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10617 Marine biology, freshwater biology, limnology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00142142

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Haematology; Plasma biochemical indices; Oxidative stress; Endocrine disrupting compounds; Histology

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2026 18:02, Mgr. Irena Doubková

Anotace

V originále

This study aimed to assess the toxicity of bisphenol A (BPA) and bisphenol F (BPF) in rainbow trout following six weeks of dietary exposure. Fish were exposed to BPA, BPF, or their combination at nominal concentrations of 10 and 1000 mu g/kg (i.e., BPA(low), BPA(high), BPFlow, BPFhigh, BPA+BPFlow). Haematological analysis revealed a significant reduction (p < 0.05) in leukocytes and lymphocytes, but only in the BPFhigh group. Plasma biochemical markers showed significant increases (p < 0.05) in creatinine in BPA(low) and elevated amylase activity in both BPF groups. Surprisingly, markers of endocrine disruption, such as vitellogenin and thyroxine, were significantly elevated (p < 0.05) only in BPFhigh and BPA+BPFlow, despite no pathological changes being observed in the gonads. Oxidative stress markers were significantly affected, with increased catalase activity (p < 0.05) in the liver, kidney, and gill across all groups. Additionally, plasma DNA damage was significantly (p < 0.05) reduced in BPA(low) and BPFhigh. In contrast, significant elevations (p < 0.05) of ceruloplasmin and ferric reducing/antioxidant power were observed in the BPA+BPFlow and both BPF groups, respectively. Histological examination revealed liver congestion and dystrophy in both BPA groups, hyaline droplet degeneration in the tubular epithelial cells of the caudal kidney across all exposed groups, and deformation of gill filaments in BPA+BPFlow and both BPA groups. Our findings underscore that the increasing use of BPA analogues may pose a greater risk than the original compound in certain contexts, emphasizing the need for further studies to understand the long-term effects of bisphenol analogues, particularly at environmentally relevant concentrations and in mixtures.

Citovat

STOKLASOVA, Vendula; Premysl MIKULA; Aneta HOLLEROVA; Petr MARSALEK; Nikola PESKOVA; Aleš FRANC; Lucie SEDLÁČKOVÁ; Frantisek TICHY; Eva POSTULKOVA; Jan MARES; Zdenka SVOBODOVA a Jana BLAHOVA. Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial. AQUATIC TOXICOLOGY. AMSTERDAM: ELSEVIER, 2025, roč. 287, neuvedeno, s. 1-11. ISSN 0166-445X. Dostupné z: https://doi.org/10.1016/j.aquatox.2025.107540.

@article{2521577,
   author = {Stoklasova, Vendula and Mikula, Premysl and Hollerova, Aneta and Marsalek, Petr and Peskova, Nikola and Franc, Aleš and Sedláčková, Lucie and Tichy, Frantisek and Postulkova, Eva and Mares, Jan and Svobodova, Zdenka and Blahova, Jana},
   article_location = {AMSTERDAM},
   article_number = {neuvedeno},
   doi = {https://doi.org/10.1016/j.aquatox.2025.107540},
   keywords = {Haematology; Plasma biochemical indices; Oxidative stress; Endocrine disrupting compounds; Histology},
   language = {eng},
   issn = {0166-445X},
   journal = {AQUATIC TOXICOLOGY},
   title = {Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial},
   url = {https://www.sciencedirect.com/science/article/pii/S0166445X25003042?via%3Dihub},
   volume = {287},
   year = {2025}
}

TY  - JOUR
ID  - 2521577
AU  - Stoklasova, Vendula - Mikula, Premysl - Hollerova, Aneta - Marsalek, Petr - Peskova, Nikola - Franc, Aleš - Sedláčková, Lucie - Tichy, Frantisek - Postulkova, Eva - Mares, Jan - Svobodova, Zdenka - Blahova, Jana
PY  - 2025
TI  - Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial
JF  - AQUATIC TOXICOLOGY
VL  - 287
IS  - neuvedeno
SP  - 1-11
EP  - 1-11
PB  - ELSEVIER
SN  - 0166445X
KW  - Haematology
KW  - Plasma biochemical indices
KW  - Oxidative stress
KW  - Endocrine disrupting compounds
KW  - Histology
UR  - https://www.sciencedirect.com/science/article/pii/S0166445X25003042?via%3Dihub
N2  - This study aimed to assess the toxicity of bisphenol A (BPA) and bisphenol F (BPF) in rainbow trout following six weeks of dietary exposure. Fish were exposed to BPA, BPF, or their combination at nominal concentrations of 10 and 1000 mu g/kg (i.e., BPA(low), BPA(high), BPFlow, BPFhigh, BPA+BPFlow). Haematological analysis revealed a significant reduction (p < 0.05) in leukocytes and lymphocytes, but only in the BPFhigh group. Plasma biochemical markers showed significant increases (p < 0.05) in creatinine in BPA(low) and elevated amylase activity in both BPF groups. Surprisingly, markers of endocrine disruption, such as vitellogenin and thyroxine, were significantly elevated (p < 0.05) only in BPFhigh and BPA+BPFlow, despite no pathological changes being observed in the gonads. Oxidative stress markers were significantly affected, with increased catalase activity (p < 0.05) in the liver, kidney, and gill across all groups. Additionally, plasma DNA damage was significantly (p < 0.05) reduced in BPA(low) and BPFhigh. In contrast, significant elevations (p < 0.05) of ceruloplasmin and ferric reducing/antioxidant power were observed in the BPA+BPFlow and both BPF groups, respectively. Histological examination revealed liver congestion and dystrophy in both BPA groups, hyaline droplet degeneration in the tubular epithelial cells of the caudal kidney across all exposed groups, and deformation of gill filaments in BPA+BPFlow and both BPA groups. Our findings underscore that the increasing use of BPA analogues may pose a greater risk than the original compound in certain contexts, emphasizing the need for further studies to understand the long-term effects of bisphenol analogues, particularly at environmentally relevant concentrations and in mixtures.
ER  -

STOKLASOVA, Vendula; Premysl MIKULA; Aneta HOLLEROVA; Petr MARSALEK; Nikola PESKOVA; Aleš FRANC; Lucie SEDLÁČKOVÁ; Frantisek TICHY; Eva POSTULKOVA; Jan MARES; Zdenka SVOBODOVA a Jana BLAHOVA. Enhanced toxicity of bisphenol F compared to its predecessor bisphenol A in rainbow trout (Oncorhynchus mykiss) during a six-week feeding trial. \textit{AQUATIC TOXICOLOGY}. AMSTERDAM: ELSEVIER, 2025, roč.~287, neuvedeno, s.~1-11. ISSN~0166-445X. Dostupné z: https://doi.org/10.1016/j.aquatox.2025.107540.

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