Non-invasive brain stimulation: current and future applications
in neurology

J 2025

Non-invasive brain stimulation: current and future applications in neurology

REKTOROVÁ, Irena; Monika PUPÍKOVÁ; Lisa FLEURY; Luboš BRABENEC; Friedhelm C. HUMMEL et al.

Základní údaje

Originální název

Non-invasive brain stimulation: current and future applications in neurology

Autoři

REKTOROVÁ, Irena; Monika PUPÍKOVÁ; Lisa FLEURY; Luboš BRABENEC a Friedhelm C. HUMMEL

Vydání

NATURE REVIEWS NEUROLOGY, Berlin, NATURE PORTFOLIO, 2025, 1759-4758

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 33.100 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/25:00142164

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

TRANSCRANIAL MAGNETIC STIMULATION; MILD COGNITIVE IMPAIRMENT; PRIMARY MOTOR CORTEX; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; POSTSTROKE APHASIA; NEURONAL-ACTIVITY; STROKE RECOVERY; DOUBLE-BLIND; L-DOPA

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 3. 2026 13:38, Mgr. Tereza Miškechová

Anotace

V originále

Device-based non-invasive brain stimulation (NIBS) techniques show promise for the treatment of neurological and psychiatric disorders, although inconsistencies in protocol designs and study findings can make the field difficult to navigate. In this Review, we discuss applications of NIBS for enhancing cognitive and motor function in people with various neurological diseases that are characterized by disruption of large-scale brain networks, including neurodegenerative diseases and brain lesion disorders such as stroke and traumatic brain injury. In particular, we focus on repetitive transcranial magnetic stimulation and transcranial electrical stimulation, as these techniques have been widely used in clinical settings and randomized controlled trials. We summarize and synthesize current knowledge, and highlight gaps and shortcomings in the existing research that make it difficult to draw firm conclusions, including small sample sizes, heterogeneous patient populations and variations in stimulation protocols. We believe that a rapid evolution of NIBS techniques from state-dependent, network-informed, multifocal and subcortical paradigms to individualized electric field modelling and accelerated NIBS protocols will improve the management of neurological disorders. However, realizing this potential will require us to address crucial challenges and acquire deeper mechanistic insights, with the aim of developing adaptive, biomarker-driven protocols to optimize target engagement, dosing and timing for each patient.

Návaznosti

GF21-13462L, projekt VaV

Název: Nové individualizované přístupy mozkové stimulace založené na synchronizaci v mozkových sítích pro zlepšení kognice zdravých seniorů a pacientů s MCI

Investor: Grantová agentura ČR, Nové individualizované přístupy mozkové stimulace založené na synchronizaci v mozkových sítích pro zlepšení kognice zdravých seniorů a pacientů s MCI, Partnerská agentura (Švýcarsko)

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NW25-04-00142, projekt VaV

Název: Neinvazivní stimulace hlubokých mozkových struktur pro ovlivnění pracovní paměti

Investor: Ministerstvo zdravotnictví ČR, Neinvazivní stimulace hlubokých mozkových struktur pro ovlivnění pracovní paměti, Podprogram 1 - standardní

Citovat

REKTOROVÁ, Irena; Monika PUPÍKOVÁ; Lisa FLEURY; Luboš BRABENEC a Friedhelm C. HUMMEL. Non-invasive brain stimulation: current and future applications in neurology. NATURE REVIEWS NEUROLOGY. Berlin: NATURE PORTFOLIO, 2025, roč. 21, č. 12, s. 669-686. ISSN 1759-4758. Dostupné z: https://doi.org/10.1038/s41582-025-01137-z.

@article{2522380,
   author = {Rektorová, Irena and Pupíková, Monika and Fleury, Lisa and Brabenec, Luboš and Hummel, Friedhelm C.},
   article_location = {Berlin},
   article_number = {12},
   doi = {https://doi.org/10.1038/s41582-025-01137-z},
   keywords = {TRANSCRANIAL MAGNETIC STIMULATION; MILD COGNITIVE IMPAIRMENT; PRIMARY MOTOR CORTEX; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; POSTSTROKE APHASIA; NEURONAL-ACTIVITY; STROKE RECOVERY; DOUBLE-BLIND; L-DOPA},
   language = {eng},
   issn = {1759-4758},
   journal = {NATURE REVIEWS NEUROLOGY},
   title = {Non-invasive brain stimulation: current and future applications in neurology},
   url = {https://www.nature.com/articles/s41582-025-01137-z},
   volume = {21},
   year = {2025}
}

TY  - JOUR
ID  - 2522380
AU  - Rektorová, Irena - Pupíková, Monika - Fleury, Lisa - Brabenec, Luboš - Hummel, Friedhelm C.
PY  - 2025
TI  - Non-invasive brain stimulation: current and future applications in neurology
JF  - NATURE REVIEWS NEUROLOGY
VL  - 21
IS  - 12
SP  - 669-686
EP  - 669-686
PB  - NATURE PORTFOLIO
SN  - 17594758
KW  - TRANSCRANIAL MAGNETIC STIMULATION
KW  - MILD COGNITIVE IMPAIRMENT
KW  - PRIMARY MOTOR CORTEX
KW  - PARKINSONS-DISEASE
KW  - ALZHEIMERS-DISEASE
KW  - POSTSTROKE APHASIA
KW  - NEURONAL-ACTIVITY
KW  - STROKE RECOVERY
KW  - DOUBLE-BLIND
KW  - L-DOPA
UR  - https://www.nature.com/articles/s41582-025-01137-z
N2  - Device-based non-invasive brain stimulation (NIBS) techniques show promise for the treatment of neurological and psychiatric disorders, although inconsistencies in protocol designs and study findings can make the field difficult to navigate. In this Review, we discuss applications of NIBS for enhancing cognitive and motor function in people with various neurological diseases that are characterized by disruption of large-scale brain networks, including neurodegenerative diseases and brain lesion disorders such as stroke and traumatic brain injury. In particular, we focus on repetitive transcranial magnetic stimulation and transcranial electrical stimulation, as these techniques have been widely used in clinical settings and randomized controlled trials. We summarize and synthesize current knowledge, and highlight gaps and shortcomings in the existing research that make it difficult to draw firm conclusions, including small sample sizes, heterogeneous patient populations and variations in stimulation protocols. We believe that a rapid evolution of NIBS techniques from state-dependent, network-informed, multifocal and subcortical paradigms to individualized electric field modelling and accelerated NIBS protocols will improve the management of neurological disorders. However, realizing this potential will require us to address crucial challenges and acquire deeper mechanistic insights, with the aim of developing adaptive, biomarker-driven protocols to optimize target engagement, dosing and timing for each patient.
ER  -

REKTOROVÁ, Irena; Monika PUPÍKOVÁ; Lisa FLEURY; Luboš BRABENEC a Friedhelm C. HUMMEL. Non-invasive brain stimulation: current and future applications in neurology. \textit{NATURE REVIEWS NEUROLOGY}. Berlin: NATURE PORTFOLIO, 2025, roč.~21, č.~12, s.~669-686. ISSN~1759-4758. Dostupné z: https://doi.org/10.1038/s41582-025-01137-z.

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