Periprosthetic inflammation: From the cellular level to
clinical implications

J 2025

Periprosthetic inflammation: From the cellular level to clinical implications

MACEŠKA, Jakub; Polina NAVRÁTILOVÁ a Monika GOLDBERGOVÁ

Základní údaje

Originální název

Periprosthetic inflammation: From the cellular level to clinical implications

Autoři

MACEŠKA, Jakub; Polina NAVRÁTILOVÁ a Monika GOLDBERGOVÁ

Vydání

JBMR PLUS, OXFORD, OXFORD UNIV PRESS, 2025, 2473-4039

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30211 Orthopaedics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.400 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

periprosthetic inflammation; implant-associated inflammation; immune response; osteolysis; clinical implications

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 2. 2026 09:18, Mgr. Tereza Miškechová

Anotace

V originále

Periprosthetic inflammation is a crucial factor contributing to aseptic loosening, the leading cause of implant failures. Metallic debris, including nanoparticles, sub-micron particles, and ions, plays a central role in triggering inflammatory responses around orthopaedic implants. Exposure to the debris activates macrophages via Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which in turn leads to the production of pro-inflammatory cytokines. This signalling cascade subsequently drives osteoclast activation, resulting in periprosthetic bone loss and, ultimately, implant loosening. Recent research has focused on strategies to prevent aseptic loosening by targeting the inflammation induced by metallic particles/ions. Pharmacological interventions aimed at modulating macrophage activation and inhibiting specific inflammatory pathways have shown promise in reducing osteoclast activity and excessive bone resorption. This review provides a comprehensive overview of the processes involved in the pathogenesis of periprosthetic inflammation, beginning with the release of metallic debris and its recognition by immune cells, followed by the inflammatory reactions that lead to osteoclastogenesis and bone loss. A detailed understanding of these molecular mechanisms is essential for the development of targeted approaches to prevent aseptic loosening, improve long-term patient outcomes, and alleviate the economic burden on healthcare systems.

Návaznosti

MUNI/A/1790/2024, interní kód MU

Název: Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

Investor: Masarykova univerzita, Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

Citovat

MACEŠKA, Jakub; Polina NAVRÁTILOVÁ a Monika GOLDBERGOVÁ. Periprosthetic inflammation: From the cellular level to clinical implications. JBMR PLUS. OXFORD: OXFORD UNIV PRESS, 2025, roč. 9, č. 11, s. 1-14. ISSN 2473-4039. Dostupné z: https://doi.org/10.1093/jbmrpl/ziaf154.

@article{2525779,
   author = {Maceška, Jakub and Navrátilová, Polina and Goldbergová, Monika},
   article_location = {OXFORD},
   article_number = {11},
   doi = {https://doi.org/10.1093/jbmrpl/ziaf154},
   keywords = {periprosthetic inflammation; implant-associated inflammation; immune response; osteolysis; clinical implications},
   language = {eng},
   issn = {2473-4039},
   journal = {JBMR PLUS},
   title = {Periprosthetic inflammation: From the cellular level to clinical implications},
   url = {https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522},
   volume = {9},
   year = {2025}
}

TY  - JOUR
ID  - 2525779
AU  - Maceška, Jakub - Navrátilová, Polina - Goldbergová, Monika
PY  - 2025
TI  - Periprosthetic inflammation: From the cellular level to clinical implications
JF  - JBMR PLUS
VL  - 9
IS  - 11
SP  - 1-14
EP  - 1-14
PB  - OXFORD UNIV PRESS
SN  - 24734039
KW  - periprosthetic inflammation
KW  - implant-associated inflammation
KW  - immune response
KW  - osteolysis
KW  - clinical implications
UR  - https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522
N2  - Periprosthetic inflammation is a crucial factor contributing to aseptic loosening, the leading cause of implant failures. Metallic debris, including nanoparticles, sub-micron particles, and ions, plays a central role in triggering inflammatory responses around orthopaedic implants. Exposure to the debris activates macrophages via Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which in turn leads to the production of pro-inflammatory cytokines. This signalling cascade subsequently drives osteoclast activation, resulting in periprosthetic bone loss and, ultimately, implant loosening. Recent research has focused on strategies to prevent aseptic loosening by targeting the inflammation induced by metallic particles/ions. Pharmacological interventions aimed at modulating macrophage activation and inhibiting specific inflammatory pathways have shown promise in reducing osteoclast activity and excessive bone resorption. This review provides a comprehensive overview of the processes involved in the pathogenesis of periprosthetic inflammation, beginning with the release of metallic debris and its recognition by immune cells, followed by the inflammatory reactions that lead to osteoclastogenesis and bone loss. A detailed understanding of these molecular mechanisms is essential for the development of targeted approaches to prevent aseptic loosening, improve long-term patient outcomes, and alleviate the economic burden on healthcare systems.
ER  -

MACEŠKA, Jakub; Polina NAVRÁTILOVÁ a Monika GOLDBERGOVÁ. Periprosthetic inflammation: From the cellular level to clinical implications. \textit{JBMR PLUS}. OXFORD: OXFORD UNIV PRESS, 2025, roč.~9, č.~11, s.~1-14. ISSN~2473-4039. Dostupné z: https://doi.org/10.1093/jbmrpl/ziaf154.

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