Electrochemical detection of fusion genes: Advancing cancer
diagnosis and therapy

J 2025

Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy

IZADI, Nasim; Aneta FRIED; Šárka ŠEVČÍKOVÁ; Johana STRMISKOVÁ; Ludmila MORÁŇOVÁ et al.

Základní údaje

Originální název

Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy

Název česky

Elektrochemická detekce fúzních genů: Pokrok v diagnostice a léčbě rakoviny

Autoři

IZADI, Nasim; Aneta FRIED ; Šárka ŠEVČÍKOVÁ ; Johana STRMISKOVÁ; Ludmila MORÁŇOVÁ; Suzana CAMPUZANO a Martin BARTOŠÍK

Vydání

Electrochimica Acta, Elsevier Science Ltd, 2025, 0013-4686

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10405 Electrochemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.600 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00142287

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Fusion genes; Electrochemical detection; Precision oncology; Cancer biomarker; DNA analysis

Štítky

143160, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 11. 2025 15:39, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Fusion genes are formed by joining segments of two different genes through translocations, deletions, chromosomal insertions, or aberrant gene splicing. These fusions, detectable at the DNA, RNA, and protein levels, are diagnostically and prognostically relevant molecular indices for the selection of targeted therapies, monitoring of minimal residual disease after treatment, and prediction of relapse. In contrast to traditional determination techniques, electroanalytical technologies provide affordable, versatile, portable, and rapid detection methods that do not compromise specificity, sensitivity, robustness, or accuracy. These advantages make them highly promising for advancing research, enabling clinical adoption, supporting pharmaceutical development, and expanding access to accurate diagnostics and effective therapies. In this context, this review article addresses the potential and opportunities offered by electroanalytical technologies for fusion gene detection. It provides a brief description of the most common fusion genes in hematological malignancies and solid tumors, an explanation of frequently used standard techniques, a critical overview of recent electrochemical (EC)-based studies targeting the most common fusion genes, and highlights the challenges faced by current EC bioassays.

Citovat

IZADI, Nasim; Aneta FRIED; Šárka ŠEVČÍKOVÁ; Johana STRMISKOVÁ; Ludmila MORÁŇOVÁ; Suzana CAMPUZANO a Martin BARTOŠÍK. Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy. Electrochimica Acta. Elsevier Science Ltd, 2025, roč. 542, December, s. 147472-147488. ISSN 0013-4686. Dostupné z: https://doi.org/10.1016/j.electacta.2025.147472.

@article{2525822,
   author = {Izadi, Nasim and Fried, Aneta and Ševčíková, Šárka and Strmisková, Johana and Moráňová, Ludmila and Campuzano, Suzana and Bartošík, Martin},
   article_number = {December},
   doi = {https://doi.org/10.1016/j.electacta.2025.147472},
   keywords = {Fusion genes; Electrochemical detection; Precision oncology; Cancer biomarker; DNA analysis},
   language = {eng},
   issn = {0013-4686},
   journal = {Electrochimica Acta},
   title = {Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy},
   url = {https://www.sciencedirect.com/science/article/pii/S0013468625018298?via%3Dihub},
   volume = {542},
   year = {2025}
}

TY  - JOUR
ID  - 2525822
AU  - Izadi, Nasim - Fried, Aneta - Ševčíková, Šárka - Strmisková, Johana - Moráňová, Ludmila - Campuzano, Suzana - Bartošík, Martin
PY  - 2025
TI  - Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy
JF  - Electrochimica Acta
VL  - 542
IS  - December
SP  - 147472
EP  - 147472
PB  - Elsevier Science Ltd
SN  - 00134686
KW  - Fusion genes
KW  - Electrochemical detection
KW  - Precision oncology
KW  - Cancer biomarker
KW  - DNA analysis
UR  - https://www.sciencedirect.com/science/article/pii/S0013468625018298?via%3Dihub
N2  - Fusion genes are formed by joining segments of two different genes through translocations, deletions, chromosomal insertions, or aberrant gene splicing. These fusions, detectable at the DNA, RNA, and protein levels, are diagnostically and prognostically relevant molecular indices for the selection of targeted therapies, monitoring of minimal residual disease after treatment, and prediction of relapse. In contrast to traditional determination techniques, electroanalytical technologies provide affordable, versatile, portable, and rapid detection methods that do not compromise specificity, sensitivity, robustness, or accuracy. These advantages make them highly promising for advancing research, enabling clinical adoption, supporting pharmaceutical development, and expanding access to accurate diagnostics and effective therapies. In this context, this review article addresses the potential and opportunities offered by electroanalytical technologies for fusion gene detection. It provides a brief description of the most common fusion genes in hematological malignancies and solid tumors, an explanation of frequently used standard techniques, a critical overview of recent electrochemical (EC)-based studies targeting the most common fusion genes, and highlights the challenges faced by current EC bioassays.
ER  -

IZADI, Nasim; Aneta FRIED; Šárka ŠEVČÍKOVÁ; Johana STRMISKOVÁ; Ludmila MORÁŇOVÁ; Suzana CAMPUZANO a Martin BARTOŠÍK. Electrochemical detection of fusion genes: Advancing cancer diagnosis and therapy. \textit{Electrochimica Acta}. Elsevier Science Ltd, 2025, roč.~542, December, s.~147472-147488. ISSN~0013-4686. Dostupné z: https://doi.org/10.1016/j.electacta.2025.147472.

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