Improving pre-operative binary grading: relevance of p53 and PR
expression in grade 2 endometrioid endometrial carcinoma

J 2025

Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma

MEIJS-HERMANNS, Puk; Henrica M J WERNER; Loes KOOREMAN; Petra BRETOVÁ; Vít WEINBERGER et al.

Základní údaje

Originální název

Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma

Autoři

Vydání

International journal of gynecological cancer, LONDON, BMJ PUBLISHING GROUP, 2025, 1048-891X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00142321

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Endometrioid Endometrial Carcinoma; p53; Progesterone Receptor; Grade 2

Štítky

14110212, 14110230, 14110240, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 10. 2025 14:29, Mgr. Tereza Miškechová

Anotace

V originále

Objective: This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas. Methods: Three European endometrial carcinoma cohort studies were included. Patients with pre-operative grade 2 endometrioid carcinoma and known pre-operative PR and p53 status were included (n = 400), as were patients with pre-operative grade 1 (n = 602) or grade 3 (n = 148) endometrioid carcinomas. Kaplan-Meier and Cox regression analyses were performed to analyze disease-specific and disease-free survival. Results: Patients with pre-operative grade 2 endometrial carcinoma and wild-type p53 plus PR-positive expression showed a similar 7-year disease-specific survival to grade 1 endometrial carcinoma patients (95.8% vs 97.5%, p = .13), while the 7-year disease-specific survival of patients with grade 2 endometrial carcinoma with p53 aberrant and/or negative PR expression (83.5%) was significantly lower (p < .001). The combination of these markers was an independent prognostic factor in multivariate Cox regression analyses. Conclusions: The prognostic impact of pre-operative p53 and PR expression in patients with grade 2 endometrioid endometrial carcinoma supports a modified binary grading system in which grade 2 patients should be pre-operatively classified as low-or high-grade depending on p53 and PR expression.

Citovat

MEIJS-HERMANNS, Puk; Henrica M J WERNER; Loes KOOREMAN; Petra BRETOVÁ; Vít WEINBERGER; Stephanie VREDE; Luthy S M ALCALA; Frederic AMANT; Jasmin ASBERGER; Markéta BEDNAŘÍKOVÁ; Dorry BOLL; Carolien M BRONKHORST; Johan BULTEN; Antonio GIL-MORENO; Ingfrid S HALDORSEN; Jitka HAUSNEROVÁ; Jutta HUVILA; Martin KOSKAS; Camilla KRAKSTAD; Heidi KUESTERS-VANDEVELDE; Gemma Mancebo MORENO; Xavier MATIAS-GUIU; Huy NGO; Brenda M PIJLMAN; Maria SANTACANA; Marieke SMINK; Jone TROVIKO; Viola M J VERHOEF; Koen VAN DE VIJVER; van Hamont DENNIS; Anneke A M VAN DER WURFF; Johanna M A PIJNENBORG a Nicole C M VISSER. Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma. International journal of gynecological cancer. LONDON: BMJ PUBLISHING GROUP, 2025, roč. 35, č. 4, s. 1-8. ISSN 1048-891X. Dostupné z: https://doi.org/10.1016/j.ijgc.2025.101682.

@article{2527458,
   author = {MeijsandHermanns, Puk and Werner, Henrica M J and Kooreman, Loes and Bretová, Petra and Weinberger, Vít and Vrede, Stephanie and Alcala, Luthy S M and Amant, Frederic and Asberger, Jasmin and Bednaříková, Markéta and Boll, Dorry and Bronkhorst, Carolien M and Bulten, Johan and GilandMoreno, Antonio and Haldorsen, Ingfrid S and Hausnerová, Jitka and Huvila, Jutta and Koskas, Martin and Krakstad, Camilla and KuestersandVandevelde, Heidi and Moreno, Gemma Mancebo and MatiasandGuiu, Xavier and Ngo, Huy and Pijlman, Brenda M and Santacana, Maria and Smink, Marieke and Troviko, Jone and Verhoef, Viola M J and van de Vijver, Koen and Dennis, van Hamont and van der Wurff, Anneke A M and Pijnenborg, Johanna M A and Visser, Nicole C M},
   article_location = {LONDON},
   article_number = {4},
   doi = {https://doi.org/10.1016/j.ijgc.2025.101682},
   keywords = {Endometrioid Endometrial Carcinoma; p53; Progesterone Receptor; Grade 2},
   language = {eng},
   issn = {1048-891X},
   journal = {International journal of gynecological cancer},
   title = {Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma},
   url = {https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(25)00799-6/fulltext},
   volume = {35},
   year = {2025}
}

TY  - JOUR
ID  - 2527458
AU  - Meijs-Hermanns, Puk - Werner, Henrica M J - Kooreman, Loes - Bretová, Petra - Weinberger, Vít - Vrede, Stephanie - Alcala, Luthy S M - Amant, Frederic - Asberger, Jasmin - Bednaříková, Markéta - Boll, Dorry - Bronkhorst, Carolien M - Bulten, Johan - Gil-Moreno, Antonio - Haldorsen, Ingfrid S - Hausnerová, Jitka - Huvila, Jutta - Koskas, Martin - Krakstad, Camilla - Kuesters-Vandevelde, Heidi - Moreno, Gemma Mancebo - Matias-Guiu, Xavier - Ngo, Huy - Pijlman, Brenda M - Santacana, Maria - Smink, Marieke - Troviko, Jone - Verhoef, Viola M J - van de Vijver, Koen - Dennis, van Hamont - van der Wurff, Anneke A M - Pijnenborg, Johanna M A - Visser, Nicole C M
PY  - 2025
TI  - Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma
JF  - International journal of gynecological cancer
VL  - 35
IS  - 4
SP  - 1-8
EP  - 1-8
PB  - BMJ PUBLISHING GROUP
SN  - 1048891X
KW  - Endometrioid Endometrial Carcinoma
KW  - p53
KW  - Progesterone Receptor
KW  - Grade 2
UR  - https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(25)00799-6/fulltext
N2  - Objective: This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas. Methods: Three European endometrial carcinoma cohort studies were included. Patients with pre-operative grade 2 endometrioid carcinoma and known pre-operative PR and p53 status were included (n = 400), as were patients with pre-operative grade 1 (n = 602) or grade 3 (n = 148) endometrioid carcinomas. Kaplan-Meier and Cox regression analyses were performed to analyze disease-specific and disease-free survival. Results: Patients with pre-operative grade 2 endometrial carcinoma and wild-type p53 plus PR-positive expression showed a similar 7-year disease-specific survival to grade 1 endometrial carcinoma patients (95.8% vs 97.5%, p = .13), while the 7-year disease-specific survival of patients with grade 2 endometrial carcinoma with p53 aberrant and/or negative PR expression (83.5%) was significantly lower (p < .001). The combination of these markers was an independent prognostic factor in multivariate Cox regression analyses. Conclusions: The prognostic impact of pre-operative p53 and PR expression in patients with grade 2 endometrioid endometrial carcinoma supports a modified binary grading system in which grade 2 patients should be pre-operatively classified as low-or high-grade depending on p53 and PR expression.
ER  -

MEIJS-HERMANNS, Puk; Henrica M J WERNER; Loes KOOREMAN; Petra BRETOVÁ; Vít WEINBERGER; Stephanie VREDE; Luthy S M ALCALA; Frederic AMANT; Jasmin ASBERGER; Markéta BEDNAŘÍKOVÁ; Dorry BOLL; Carolien M BRONKHORST; Johan BULTEN; Antonio GIL-MORENO; Ingfrid S HALDORSEN; Jitka HAUSNEROVÁ; Jutta HUVILA; Martin KOSKAS; Camilla KRAKSTAD; Heidi KUESTERS-VANDEVELDE; Gemma Mancebo MORENO; Xavier MATIAS-GUIU; Huy NGO; Brenda M PIJLMAN; Maria SANTACANA; Marieke SMINK; Jone TROVIKO; Viola M J VERHOEF; Koen VAN DE VIJVER; van Hamont DENNIS; Anneke A M VAN DER WURFF; Johanna M A PIJNENBORG a Nicole C M VISSER. Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma. \textit{International journal of gynecological cancer}. LONDON: BMJ PUBLISHING GROUP, 2025, roč.~35, č.~4, s.~1-8. ISSN~1048-891X. Dostupné z: https://doi.org/10.1016/j.ijgc.2025.101682.

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