Near-infrared spectroscopy derived indexes as a potential
predictor of plaque burden volume progression after unprotected
left main coronary artery intervention

J 2025

Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention

HUDEC, Martin; Jan KAŇOVSKÝ; Vojtěch BRÁZDIL; Martin POLOCZEK; Ivona KASK et al.

Základní údaje

Originální název

Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention

Autoři

Vydání

Cor et Vasa, PRAGUE 2, CZECH SOC CARDIOLOGY & CZECH SOC CARDIOVASCULAR SURGERY, 2025, 0010-8650

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00142324

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Intravascular imaging; IVUS; LCBI; Left main; MaxLCBI4mm; NIRS; Plaque progression; Plaque volume

Štítky

14110211, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 10. 2025 14:55, Mgr. Tereza Miškechová

Anotace

V originále

Background: Coronary artery disease (CAD) is the leading cause of death worldwide, which has driven significant advances in the field of interventional cardiology. The combination of intravascular ultrasound (IVUS) and near-infrared light spectroscopy (NIRS) offers a detailed view of coronary artery morphology and plaque composition. This advanced imaging capability facilitates a more accurate assessment of CAD and enhances therapeutic strategies. Objective: NIRS can detect and quantify lipid content in atherosclerotic plaque using the Lipid Core Burden Index (LCBI) and the Maximal Lipid Core Burden Index in a 4 mm segment (maxLCBI4mm). In this study, we examined the relationship between these indices and atherosclerotic plaque progression in the crucial area of the left main coronary artery (LM) during a follow-up period of 9 to 12 months after percutaneous coronary interventions (PCI). Methods: A prospective, single-centre study was conducted involving 27 patients with significant left main stenosis who underwent IVUS-NIRS guided PCI. Serial assessments of the LCBI, maxLCBI4mm, and IVUS-derived plaque volume (PV) were performed at baseline, immediately post-PCI, and during follow-up at 9 to 12 months in 18 patients. Results: The mean age of the study population was 72.7 years, with a predominance of male patients (88%). The average LCBI of the LM coronary artery before PCI was 128.9 +/- 122.0, while maxLCBI4mm was 263.7 +/- 172.0. The IVUS-measured PV post-PCI was 418.7 +/- 203.3 mm3, increasing to 454.5 +/- 209.4 mm3 at follow-up (p = 0.105). Analysis revealed no significant correlation between the difference in PV and baseline LCBI or maxLCBI4mm, with p-values of 0.626 and 0.786, respectively. Conclusion: This study found no significant association between initial LCBI and maxLCBI4mm segment values and subsequent changes in PV in the left main coronary artery. However, correlation graphs indicate a trend toward decreased PV in patients with high initial LCBI and maxLCBI4mm.

Citovat

HUDEC, Martin; Jan KAŇOVSKÝ; Vojtěch BRÁZDIL; Martin POLOCZEK; Ivona KASK; Kristyna HOCHMANOVA; Radka SMITALOVA; Otakar BOČEK; Petr JERABEK; Roman STIPAL; Simona LITTNEROVÁ; Jiří JARKOVSKÝ; Klára BENEŠOVÁ a Petr KALA. Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention. Cor et Vasa. PRAGUE 2: CZECH SOC CARDIOLOGY & CZECH SOC CARDIOVASCULAR SURGERY, 2025, roč. 67, č. 1, s. 6-15. ISSN 0010-8650. Dostupné z: https://doi.org/10.33678/cor.2025.010.

@article{2527462,
   author = {Hudec, Martin and Kaňovský, Jan and Brázdil, Vojtěch and Poloczek, Martin and Kask, Ivona and Hochmanova, Kristyna and Smitalova, Radka and Boček, Otakar and Jerabek, Petr and Stipal, Roman and Littnerová, Simona and Jarkovský, Jiří and Benešová, Klára and Kala, Petr},
   article_location = {PRAGUE 2},
   article_number = {1},
   doi = {https://doi.org/10.33678/cor.2025.010},
   keywords = {Intravascular imaging; IVUS; LCBI; Left main; MaxLCBI4mm; NIRS; Plaque progression; Plaque volume},
   language = {eng},
   issn = {0010-8650},
   journal = {Cor et Vasa},
   title = {Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention},
   url = {https://e-coretvasa.cz/artkey/cor-202501-0001_near-infrared-spectroscopy-derived-indexes-as-a-potential-predictor-of-plaque-burden-volume-progression-after-u.php},
   volume = {67},
   year = {2025}
}

TY  - JOUR
ID  - 2527462
AU  - Hudec, Martin - Kaňovský, Jan - Brázdil, Vojtěch - Poloczek, Martin - Kask, Ivona - Hochmanova, Kristyna - Smitalova, Radka - Boček, Otakar - Jerabek, Petr - Stipal, Roman - Littnerová, Simona - Jarkovský, Jiří - Benešová, Klára - Kala, Petr
PY  - 2025
TI  - Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention
JF  - Cor et Vasa
VL  - 67
IS  - 1
SP  - 6-15
EP  - 6-15
PB  - CZECH SOC CARDIOLOGY & CZECH SOC CARDIOVASCULAR SURGERY
SN  - 00108650
KW  - Intravascular imaging
KW  - IVUS
KW  - LCBI
KW  - Left main
KW  - MaxLCBI4mm
KW  - NIRS
KW  - Plaque progression
KW  - Plaque volume
UR  - https://e-coretvasa.cz/artkey/cor-202501-0001_near-infrared-spectroscopy-derived-indexes-as-a-potential-predictor-of-plaque-burden-volume-progression-after-u.php
N2  - Background: Coronary artery disease (CAD) is the leading cause of death worldwide, which has driven significant advances in the field of interventional cardiology. The combination of intravascular ultrasound (IVUS) and near-infrared light spectroscopy (NIRS) offers a detailed view of coronary artery morphology and plaque composition. This advanced imaging capability facilitates a more accurate assessment of CAD and enhances therapeutic strategies. Objective: NIRS can detect and quantify lipid content in atherosclerotic plaque using the Lipid Core Burden Index (LCBI) and the Maximal Lipid Core Burden Index in a 4 mm segment (maxLCBI4mm). In this study, we examined the relationship between these indices and atherosclerotic plaque progression in the crucial area of the left main coronary artery (LM) during a follow-up period of 9 to 12 months after percutaneous coronary interventions (PCI). Methods: A prospective, single-centre study was conducted involving 27 patients with significant left main stenosis who underwent IVUS-NIRS guided PCI. Serial assessments of the LCBI, maxLCBI4mm, and IVUS-derived plaque volume (PV) were performed at baseline, immediately post-PCI, and during follow-up at 9 to 12 months in 18 patients. Results: The mean age of the study population was 72.7 years, with a predominance of male patients (88%). The average LCBI of the LM coronary artery before PCI was 128.9 +/- 122.0, while maxLCBI4mm was 263.7 +/- 172.0. The IVUS-measured PV post-PCI was 418.7 +/- 203.3 mm3, increasing to 454.5 +/- 209.4 mm3 at follow-up (p = 0.105). Analysis revealed no significant correlation between the difference in PV and baseline LCBI or maxLCBI4mm, with p-values of 0.626 and 0.786, respectively. Conclusion: This study found no significant association between initial LCBI and maxLCBI4mm segment values and subsequent changes in PV in the left main coronary artery. However, correlation graphs indicate a trend toward decreased PV in patients with high initial LCBI and maxLCBI4mm.
ER  -

HUDEC, Martin; Jan KAŇOVSKÝ; Vojtěch BRÁZDIL; Martin POLOCZEK; Ivona KASK; Kristyna HOCHMANOVA; Radka SMITALOVA; Otakar BOČEK; Petr JERABEK; Roman STIPAL; Simona LITTNEROVÁ; Jiří JARKOVSKÝ; Klára BENEŠOVÁ a Petr KALA. Near-infrared spectroscopy derived indexes as a potential predictor of plaque burden volume progression after unprotected left main coronary artery intervention. \textit{Cor et Vasa}. PRAGUE 2: CZECH SOC CARDIOLOGY \&{} CZECH SOC CARDIOVASCULAR SURGERY, 2025, roč.~67, č.~1, s.~6-15. ISSN~0010-8650. Dostupné z: https://doi.org/10.33678/cor.2025.010.

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