2025
PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS
PÍŽOVÁ, Hana; Jakub TREML a Michael NOVÁKZákladní údaje
Originální název
PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS
Autoři
PÍŽOVÁ, Hana; Jakub TREML a Michael NOVÁK
Vydání
53rd Conference SYNTHESIS AND ANALYSIS OF DRUGS 2025, 2025
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
10400 1.4 Chemical sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Organizační jednotka
Farmaceutická fakulta
ISBN
978-80-280-0773-7
Klíčová slova anglicky
TETRAHYDOCANNABINOL; ENDOCANNABINOID SYSTEM
Změněno: 13. 11. 2025 13:25, Mgr. Hana Pížová, Ph.D.
Anotace
V originále
Tetrahydrocannabinol (THC) is the main psychoactive component of Cannabis sativa and a ligand of the cannabinoid receptors CB1 and CB2. These G-protein-coupled receptors are part of the endocannabinoid system, which regulates a wide array of physiological processes. Although THC and its analogues exhibits a wide range of biological activities through its interaction with cannabinoid receptors, their clinical use is limited by poor water solubility, psychoactive side effects, and insufficient receptor selectivity [2]. Chemical modification of the THC structure represents a promising strategy to overcome these limitations and generate new compounds with improved pharmacokinetic and pharmacodynamic profiles. The introduction of amino group offers multiple advantages: increased solubility, the ability for salt formation, better receptor interaction via hydrogen bonding or electrostatic forces, and access to a broad range of further derivatization.
Návaznosti
| MUNI/C/1738/2023, interní kód MU |
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