Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of
House Mouse Parasites Pneumocystis murina and Syphacia obvelata
Using Genome Polarisation

J 2025

Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation

PETRUŽELA, Jan; Beate NÜRNBERGER; Alexis RIBAS; Georgios KOUTSOVOULOS; Dagmar ČÍŽKOVÁ et al.

Základní údaje

Originální název

Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation

Autoři

Vydání

Molecular Ecology, Wiley, 2025, 0962-1083

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10613 Zoology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00142575

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

adaptive introgression; genome polarisation; parasite hybrid zones; Pneumocystis murina; population genomics; Syphacia obvelata

Štítky

14314020, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 11. 2025 15:34, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Parasites are expected to hybridise in similar ways to free-living organisms, although this may be modified by their reduced genome architecture. Recombinant strains and taxa of hybrid origin can be studied in nature where hosts come into secondary contact. Here we apply genome-wide analysis to parasites from a contact previously characterised for many individuals using classical markers. The host contact is the European house mouse hybrid zone; the parasites are lung fungus Pneumocystis and gut pinworm Syphacia. The genomic (many loci) and classical (many-individual) results are broadly consistent in scale and centring of transitions across the host hybrid zone. Whole mitogenome comparisons confirm earlier suggestions that parasite divergence is low compared to their hosts, perhaps due to reduced-genome stabilising selection. In the recombining genome, we are able to show blocks of the parasite genome of alternating host origin, including one Pneumocystis strain which appears to be an F3+ cross and one recombinant Syphacia strain found over multiple localities. Functional analyses of introgressing genes show enrichment for genes likely important for parasitic lifestyle. Our work confirms that evolutionary models of hybridisation apply equally to hosts and their parasites.

Citovat

PETRUŽELA, Jan; Beate NÜRNBERGER; Alexis RIBAS; Georgios KOUTSOVOULOS; Dagmar ČÍŽKOVÁ; Alena FORNŮSKOVÁ; Tatiana AGHOVÁ; Mark BLAXTER; Joëlle,Marie,Chantal GOÜY DE BELLOCQ FEUQUIERES a Stuart James Edmisti BAIRD. Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation. Molecular Ecology. Wiley, 2025, roč. 34, č. 21, s. "e70044", 23 s. ISSN 0962-1083. Dostupné z: https://doi.org/10.1111/mec.70044.

@article{2533303,
   author = {Petružela, Jan and Nürnberger, Beate and Ribas, Alexis and Koutsovoulos, Georgios and Čížková, Dagmar and Fornůsková, Alena and Aghová, Tatiana and Blaxter, Mark and Goüy de Bellocq Feuquieres, Joëlle,Marie,Chantal and Baird, Stuart James Edmisti},
   article_number = {21},
   doi = {https://doi.org/10.1111/mec.70044},
   keywords = {adaptive introgression; genome polarisation; parasite hybrid zones; Pneumocystis murina; population genomics; Syphacia obvelata},
   language = {eng},
   issn = {0962-1083},
   journal = {Molecular Ecology},
   title = {Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation},
   url = {http://onlinelibrary.wiley.com/doi/full/10.1111/mec.70044},
   volume = {34},
   year = {2025}
}

TY  - JOUR
ID  - 2533303
AU  - Petružela, Jan - Nürnberger, Beate - Ribas, Alexis - Koutsovoulos, Georgios - Čížková, Dagmar - Fornůsková, Alena - Aghová, Tatiana - Blaxter, Mark - Goüy de Bellocq Feuquieres, Joëlle,Marie,Chantal - Baird, Stuart James Edmisti
PY  - 2025
TI  - Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation
JF  - Molecular Ecology
VL  - 34
IS  - 21
SP  - "e70044"
EP  - "e70044"
PB  - Wiley
SN  - 09621083
KW  - adaptive introgression
KW  - genome polarisation
KW  - parasite hybrid zones
KW  - Pneumocystis murina
KW  - population genomics
KW  - Syphacia obvelata
UR  - http://onlinelibrary.wiley.com/doi/full/10.1111/mec.70044
N2  - Parasites are expected to hybridise in similar ways to free-living organisms, although this may be modified by their reduced genome architecture. Recombinant strains and taxa of hybrid origin can be studied in nature where hosts come into secondary contact. Here we apply genome-wide analysis to parasites from a contact previously characterised for many individuals using classical markers. The host contact is the European house mouse hybrid zone; the parasites are lung fungus Pneumocystis and gut pinworm Syphacia. The genomic (many loci) and classical (many-individual) results are broadly consistent in scale and centring of transitions across the host hybrid zone. Whole mitogenome comparisons confirm earlier suggestions that parasite divergence is low compared to their hosts, perhaps due to reduced-genome stabilising selection. In the recombining genome, we are able to show blocks of the parasite genome of alternating host origin, including one Pneumocystis strain which appears to be an F3+ cross and one recombinant Syphacia strain found over multiple localities. Functional analyses of introgressing genes show enrichment for genes likely important for parasitic lifestyle. Our work confirms that evolutionary models of hybridisation apply equally to hosts and their parasites.
ER  -

PETRUŽELA, Jan; Beate NÜRNBERGER; Alexis RIBAS; Georgios KOUTSOVOULOS; Dagmar ČÍŽKOVÁ; Alena FORNŮSKOVÁ; Tatiana AGHOVÁ; Mark BLAXTER; Jo$\backslash$''elle,Marie,Chantal GOÜY DE BELLOCQ FEUQUIERES a Stuart James Edmisti BAIRD. Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation. \textit{Molecular Ecology}. Wiley, 2025, roč.~34, č.~21, s.~''e70044'', 23 s. ISSN~0962-1083. Dostupné z: https://doi.org/10.1111/mec.70044.

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