Risk factors associated with higher WHO grade in meningiomas: a
multicentric study of 552 skull base meningiomas

J 2025

Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas

MAY, Michaela; Vojtech SEDLAK; Ladislav PECEN; Vladimir PRIBAN; Pavel BUCHVALD et al.

Základní údaje

Originální název

Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas

Autoři

MAY, Michaela; Vojtech SEDLAK; Ladislav PECEN; Vladimir PRIBAN; Pavel BUCHVALD; Jiří FIEDLER; Miroslav VAVERKA; Radim LIPINA; Stefan REGULI; Jozef MALIK; Martin CERNY; David NETUKA a Vladimir BENES

Vydání

Nature Scientific Reports, Berlin, NATURE RESEARCH, 2025, 2045-2322

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1038/s41598-025-87882-z

UT WoS

001410922100022

Klíčová slova anglicky

Meningioma; Skull base; Surgery; Tumor grading; Risk factors; Case series

Změněno: 25. 11. 2025 13:31, Mgr. Tereza Miškechová

Anotace

V originále

The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A prognostic model predicting the probability of WHO grade 2 skull base meningioma (AUC 0.79; SE 0.04; 95% Wald Confidence Limits (0.71; 0.86)) based on meningioma diameter, presence of an arachnoid plane and cranial nerve palsy was built. Accurate preoperative detection of WHO grade in skull base meningiomas is essential for effective treatment planning. Our logistic regression model, based on diameter, cranial nerve palsy, and arachnoid plane, is tailored for detecting WHO grade 2 skull base meningiomas, even in outpatient settings.

Citovat

MAY, Michaela; Vojtech SEDLAK; Ladislav PECEN; Vladimir PRIBAN; Pavel BUCHVALD; Jiří FIEDLER; Miroslav VAVERKA; Radim LIPINA; Stefan REGULI; Jozef MALIK; Martin CERNY; David NETUKA a Vladimir BENES. Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas. Nature Scientific Reports. Berlin: NATURE RESEARCH, 2025, roč. 15, č. 1, 11 s. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-87882-z.

@article{2535505,
   author = {May, Michaela and Sedlak, Vojtech and Pecen, Ladislav and Priban, Vladimir and Buchvald, Pavel and Fiedler, Jiří and Vaverka, Miroslav and Lipina, Radim and Reguli, Stefan and Malik, Jozef and Cerny, Martin and Netuka, David and Benes, Vladimir},
   article_location = {Berlin},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-025-87882-z},
   keywords = {Meningioma; Skull base; Surgery; Tumor grading; Risk factors; Case series},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   note = {Bez afiliace k MU.},
   title = {Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas},
   url = {https://www.nature.com/articles/s41598-025-87882-z},
   volume = {15},
   year = {2025}
}

TY  - JOUR
ID  - 2535505
AU  - May, Michaela - Sedlak, Vojtech - Pecen, Ladislav - Priban, Vladimir - Buchvald, Pavel - Fiedler, Jiří - Vaverka, Miroslav - Lipina, Radim - Reguli, Stefan - Malik, Jozef - Cerny, Martin - Netuka, David - Benes, Vladimir
PY  - 2025
TI  - Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas
JF  - Nature Scientific Reports
VL  - 15
IS  - 1
PB  - NATURE RESEARCH
SN  - 20452322
N1  - Bez afiliace k MU.
KW  - Meningioma
KW  - Skull base
KW  - Surgery
KW  - Tumor grading
KW  - Risk factors
KW  - Case series
UR  - https://www.nature.com/articles/s41598-025-87882-z
N2  - The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A prognostic model predicting the probability of WHO grade 2 skull base meningioma (AUC 0.79; SE 0.04; 95% Wald Confidence Limits (0.71; 0.86)) based on meningioma diameter, presence of an arachnoid plane and cranial nerve palsy was built. Accurate preoperative detection of WHO grade in skull base meningiomas is essential for effective treatment planning. Our logistic regression model, based on diameter, cranial nerve palsy, and arachnoid plane, is tailored for detecting WHO grade 2 skull base meningiomas, even in outpatient settings.
ER  -

MAY, Michaela; Vojtech SEDLAK; Ladislav PECEN; Vladimir PRIBAN; Pavel BUCHVALD; Jiří FIEDLER; Miroslav VAVERKA; Radim LIPINA; Stefan REGULI; Jozef MALIK; Martin CERNY; David NETUKA a Vladimir BENES. Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas. \textit{Nature Scientific Reports}. Berlin: NATURE RESEARCH, 2025, roč.~15, č.~1, 11 s. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-87882-z.

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