Orchestrating movement: the role of Caveolin-1 in migration and
metastasis

J 2025

Orchestrating movement: the role of Caveolin-1 in migration and metastasis

NAVRÁTIL, Jiří; Martina RAUDENSKÁ; Monika KRATOCHVÍLOVÁ; Jan BALVAN; Yoav David SHAUL et al.

Základní údaje

Originální název

Orchestrating movement: the role of Caveolin-1 in migration and metastasis

Autoři

NAVRÁTIL, Jiří ; Martina RAUDENSKÁ ; Monika KRATOCHVÍLOVÁ ; Jan BALVAN; Yoav David SHAUL a Michal MASAŘÍK

Vydání

Molecular Cancer, LONDON, BMC, 2025, 1476-4598

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 33.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00142815

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Caveolin-1; Cancer; Metastasis; Modes of migration; Caveolae

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 12. 2025 13:35, Mgr. Tereza Miškechová

Anotace

V originále

Cancer metastasis is a complex, multi-step process that accounts for the majority of cancer-related deaths. Cell motility and directional migration are central to these processes. Cell migration's molecular mechanisms and metastatic disease progression are strongly correlated, and Caveolin-1 (CAV1) is expected to be involved in metastasis based on its role in migrating cells. In early-stage cancers, CAV1 typically suppresses tumour growth by inhibiting cell proliferation and stabilising cellular signalling, and its downregulation or loss is commonly linked to tumour initiation. However, in advanced cancers, CAV1 expression is often upregulated and facilitates tumour progression by enhancing cell migration, invasion, metastasis, and resistance to therapy. Consequently, CAV1 has emerged as a critical mediator in transitioning from localised tumour growth to metastatic spread. However, the context-dependent roles of CAV1 make it difficult to understand its role in metastasis. This review aims to provide a comprehensive overview of the involvement of CAV1 in different modes of cancer cell migration and metastasis. We discuss its molecular functions, context-dependent roles, and interactions with key signalling pathways, including extracellular vesicle signalling, that control cell movement, shedding light on its complex contribution to cancer progression.

Návaznosti

MUNI/A/1790/2024, interní kód MU

Název: Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

Investor: Masarykova univerzita, Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

MUNI/R/1316/2024, interní kód MU

Název: CAREER RESTART Monika Kratochvílová 2024

Investor: Masarykova univerzita, CAREER RESTART Monika Kratochvílová 2024, CAREER RESTART

NU22-03-00202, projekt VaV

Název: Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku, Podprogram 1 - standardní

Citovat

NAVRÁTIL, Jiří; Martina RAUDENSKÁ; Monika KRATOCHVÍLOVÁ; Jan BALVAN; Yoav David SHAUL a Michal MASAŘÍK. Orchestrating movement: the role of Caveolin-1 in migration and metastasis. Molecular Cancer. LONDON: BMC, 2025, roč. 24, č. 1, s. 1-26. ISSN 1476-4598. Dostupné z: https://doi.org/10.1186/s12943-025-02469-6.

@article{2537915,
   author = {Navrátil, Jiří and Raudenská, Martina and Kratochvílová, Monika and Balvan, Jan and Shaul, Yoav David and Masařík, Michal},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/s12943-025-02469-6},
   keywords = {Caveolin-1; Cancer; Metastasis; Modes of migration; Caveolae},
   language = {eng},
   issn = {1476-4598},
   journal = {Molecular Cancer},
   title = {Orchestrating movement: the role of Caveolin-1 in migration and metastasis},
   url = {https://link.springer.com/article/10.1186/s12943-025-02469-6?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate},
   volume = {24},
   year = {2025}
}

TY  - JOUR
ID  - 2537915
AU  - Navrátil, Jiří - Raudenská, Martina - Kratochvílová, Monika - Balvan, Jan - Shaul, Yoav David - Masařík, Michal
PY  - 2025
TI  - Orchestrating movement: the role of Caveolin-1 in migration and metastasis
JF  - Molecular Cancer
VL  - 24
IS  - 1
SP  - 1-26
EP  - 1-26
PB  - BMC
SN  - 14764598
KW  - Caveolin-1
KW  - Cancer
KW  - Metastasis
KW  - Modes of migration
KW  - Caveolae
UR  - https://link.springer.com/article/10.1186/s12943-025-02469-6?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
N2  - Cancer metastasis is a complex, multi-step process that accounts for the majority of cancer-related deaths. Cell motility and directional migration are central to these processes. Cell migration's molecular mechanisms and metastatic disease progression are strongly correlated, and Caveolin-1 (CAV1) is expected to be involved in metastasis based on its role in migrating cells. In early-stage cancers, CAV1 typically suppresses tumour growth by inhibiting cell proliferation and stabilising cellular signalling, and its downregulation or loss is commonly linked to tumour initiation. However, in advanced cancers, CAV1 expression is often upregulated and facilitates tumour progression by enhancing cell migration, invasion, metastasis, and resistance to therapy. Consequently, CAV1 has emerged as a critical mediator in transitioning from localised tumour growth to metastatic spread. However, the context-dependent roles of CAV1 make it difficult to understand its role in metastasis. This review aims to provide a comprehensive overview of the involvement of CAV1 in different modes of cancer cell migration and metastasis. We discuss its molecular functions, context-dependent roles, and interactions with key signalling pathways, including extracellular vesicle signalling, that control cell movement, shedding light on its complex contribution to cancer progression.
ER  -

NAVRÁTIL, Jiří; Martina RAUDENSKÁ; Monika KRATOCHVÍLOVÁ; Jan BALVAN; Yoav David SHAUL a Michal MASAŘÍK. Orchestrating movement: the role of Caveolin-1 in migration and metastasis. \textit{Molecular Cancer}. LONDON: BMC, 2025, roč.~24, č.~1, s.~1-26. ISSN~1476-4598. Dostupné z: https://doi.org/10.1186/s12943-025-02469-6.

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