Glycerol-Enhanced Gum Karaya Hydrogel Films with a
Sandwich-like Structure Enriched with Octenidine for
Antibacterial Action against Multidrug-Resistant Bacteria

J 2025

Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria

CERNA, Eva; Vilem NEDELA; Eva TIHLARIKOVA; Jana BRTNIKOVA; Zdenka FOHLEROVA et al.

Základní údaje

Originální název

Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria

Autoři

CERNA, Eva; Vilem NEDELA; Eva TIHLARIKOVA; Jana BRTNIKOVA; Zdenka FOHLEROVA; Břetislav LIPOVÝ; Lukáš VACEK; Filip RŮŽIČKA ; Jana MATULOVA a Lucy VOJTOVA

Vydání

ACS OMEGA, WASHINGTON, AMER CHEMICAL SOC, 2025, 2470-1343

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20601 Medical engineering

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Absorption; Alcohols; Hydrogels; Polymers; Stability

Štítky

14110113

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 2. 2026 10:15, Mgr. Tereza Miškechová

Anotace

V originále

This study explores the innovative approach in the development of freeze-dried hydrogel films, leveraging the unique properties of gum Karaya (GK), poly(vinyl alcohol) (PVA), poly(ethylene glycol) (PEG), and glycerol with a coating of octenidine dihydrochloride (OCT). These innovative hydrogel films exhibit at a certain glycerol concentration a sandwich-like structure, achieved through a tailored freeze-drying process, which enhances transparency and mechanical stability. OCT provides superior antibacterial performance, effectively combating multidrug-resistant bacteria with a controlled and gradual release mechanism, surpassing conventional OCT solutions that require frequent reapplication for infected wound treatment without the creation of bacterial resistance. Advanced environmental scanning electron microscopy (A-ESEM) reveals the complex microstructure of the hydrogel, highlighting the dense surface layer and interconnected porous bulk. Variations in glycerol concentrations proved to significantly impact hydrogels' properties. Increasing the glycerol concentration decreases the pore size (around 4.5 mu m) while enhancing the polymer network density and flexibility. However, low concentration increases the pore size (7.8-15.6 mu m), impacting enhanced swelling behavior and hydrolytic stability. OCT's rapid antibacterial action, releasing over 30% within the first hour and maintaining prolonged activity for up to 2 weeks, emphasizes the material's potential for diverse applications. Hydrogels' remarkable transparency, porosity, structural stability, and antibacterial efficacy against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli strains suggest promising uses as transparent dressings, biomedical devices, and infection-resistant surfaces.

Návaznosti

NU20-05-00166, projekt VaV

Název: Nové přístupy k hojení infikovaných ran pomocí hydrogelů z přírodní pryskyřice Gum Karaya modifikovaných inovativními komponenty cílenými na multirezistentní kmeny bakterií (Akronym: NPHIRPHGK)

Investor: Ministerstvo zdravotnictví ČR, Nové přístupy k hojení infikovaných ran pomocí hydrogelů z přírodní pryskyřice Gum Karaya modifikovaných inovativními komponenty cílenými na multirezistentní kmeny bakterií, Podprogram 1 - standardní

Citovat

CERNA, Eva; Vilem NEDELA; Eva TIHLARIKOVA; Jana BRTNIKOVA; Zdenka FOHLEROVA; Břetislav LIPOVÝ; Lukáš VACEK; Filip RŮŽIČKA; Jana MATULOVA a Lucy VOJTOVA. Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria. ACS OMEGA. WASHINGTON: AMER CHEMICAL SOC, 2025, roč. 10, č. 27, s. 29530-29546. ISSN 2470-1343. Dostupné z: https://doi.org/10.1021/acsomega.5c02915.

@article{2540948,
   author = {Cerna, Eva and Nedela, Vilem and Tihlarikova, Eva and Brtnikova, Jana and Fohlerova, Zdenka and Lipový, Břetislav and Vacek, Lukáš and Růžička, Filip and Matulova, Jana and Vojtova, Lucy},
   article_location = {WASHINGTON},
   article_number = {27},
   doi = {https://doi.org/10.1021/acsomega.5c02915},
   keywords = {Absorption; Alcohols; Hydrogels; Polymers; Stability},
   language = {eng},
   issn = {2470-1343},
   journal = {ACS OMEGA},
   title = {Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria},
   url = {https://pubs.acs.org/doi/10.1021/acsomega.5c02915},
   volume = {10},
   year = {2025}
}

TY  - JOUR
ID  - 2540948
AU  - Cerna, Eva - Nedela, Vilem - Tihlarikova, Eva - Brtnikova, Jana - Fohlerova, Zdenka - Lipový, Břetislav - Vacek, Lukáš - Růžička, Filip - Matulova, Jana - Vojtova, Lucy
PY  - 2025
TI  - Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria
JF  - ACS OMEGA
VL  - 10
IS  - 27
SP  - 29530-29546
EP  - 29530-29546
PB  - AMER CHEMICAL SOC
SN  - 24701343
KW  - Absorption
KW  - Alcohols
KW  - Hydrogels
KW  - Polymers
KW  - Stability
UR  - https://pubs.acs.org/doi/10.1021/acsomega.5c02915
N2  - This study explores the innovative approach in the development of freeze-dried hydrogel films, leveraging the unique properties of gum Karaya (GK), poly(vinyl alcohol) (PVA), poly(ethylene glycol) (PEG), and glycerol with a coating of octenidine dihydrochloride (OCT). These innovative hydrogel films exhibit at a certain glycerol concentration a sandwich-like structure, achieved through a tailored freeze-drying process, which enhances transparency and mechanical stability. OCT provides superior antibacterial performance, effectively combating multidrug-resistant bacteria with a controlled and gradual release mechanism, surpassing conventional OCT solutions that require frequent reapplication for infected wound treatment without the creation of bacterial resistance. Advanced environmental scanning electron microscopy (A-ESEM) reveals the complex microstructure of the hydrogel, highlighting the dense surface layer and interconnected porous bulk. Variations in glycerol concentrations proved to significantly impact hydrogels' properties. Increasing the glycerol concentration decreases the pore size (around 4.5 mu m) while enhancing the polymer network density and flexibility. However, low concentration increases the pore size (7.8-15.6 mu m), impacting enhanced swelling behavior and hydrolytic stability. OCT's rapid antibacterial action, releasing over 30% within the first hour and maintaining prolonged activity for up to 2 weeks, emphasizes the material's potential for diverse applications. Hydrogels' remarkable transparency, porosity, structural stability, and antibacterial efficacy against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli strains suggest promising uses as transparent dressings, biomedical devices, and infection-resistant surfaces.
ER  -

CERNA, Eva; Vilem NEDELA; Eva TIHLARIKOVA; Jana BRTNIKOVA; Zdenka FOHLEROVA; Břetislav LIPOVÝ; Lukáš VACEK; Filip RŮŽIČKA; Jana MATULOVA a Lucy VOJTOVA. Glycerol-Enhanced Gum Karaya Hydrogel Films with a Sandwich-like Structure Enriched with Octenidine for Antibacterial Action against Multidrug-Resistant Bacteria. \textit{ACS OMEGA}. WASHINGTON: AMER CHEMICAL SOC, 2025, roč.~10, č.~27, s.~29530-29546. ISSN~2470-1343. Dostupné z: https://doi.org/10.1021/acsomega.5c02915.

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