Network hubs supporting memory encoding: Implications for
cognitive preservation in epilepsy surgery

J 2026

Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery

MATOUŠKOVÁ, Barbora; Jan CIMBALNIK; Pavel DANIEL; Martin KOJAN; Robert ROMAN et al.

Základní údaje

Originální název

Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery

Autoři

MATOUŠKOVÁ, Barbora ; Jan CIMBALNIK; Pavel DANIEL ; Martin KOJAN ; Robert ROMAN ; Lenka JURKOVIČOVÁ ; Martin PAIL; Milan BRÁZDIL; Michal KUCEWICZ a Petr KLIMES

Vydání

Epilepsia, Hoboken, WILEY-BLACKWELL, 2026, 0013-9580

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.600 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

free recall task; functional connectivity; inferior frontal gyrus; intracranial EEG; middle temporal gyrus

Štítky

14110127, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 3. 2026 14:24, Mgr. Tereza Miškechová

Anotace

V originále

Objective Memory impairments are common in neurological disorders, especially drug-resistant epilepsy, where cognitive deficits such as accelerated long-term forgetting may occur before surgery due to interictal/ictal discharges, antiseizure medications, and disease progression. Postsurgical memory decline affects 40%-60% of patients. Understanding the neural mechanisms of memory encoding is essential for identifying critical network hubs and guiding surgical interventions that preserve cognitive function.Methods We analyzed intracranial electroencephalographic recordings from epilepsy patients (n = 15) performing a verbal memory encoding task to identify key structures involved in successful memory formation. Functional connectivity was computed using multiple features across several frequency bands. Temporal dynamics of connectivity were examined to characterize pre-encoding and encoding phases.Results The middle temporal gyrus (MTG) consistently emerged as a verbal memory hub across features and frequency bands. The inferior frontal gyrus (IFG) was identified as a beta-band-specific hub via phase synchrony. Temporal analyses revealed that MTG exhibited stable and widespread connectivity differences across all encoding phases, suggesting a role in pre-encoding network priming. In contrast, IFG displayed a transient decrease in connectivity and spatial extent during early encoding, indicating a more focal and dynamic contribution.Significance These findings suggest that successful memory encoding relies on widespread, frequency-specific connectivity patterns centered on MTG, complemented by transient, localized IFG activity. Identifying such hubs may inform surgical planning by highlighting regions critical for cognitive outcomes, ultimately supporting strategies to preserve memory in epilepsy surgery.

Citovat

MATOUŠKOVÁ, Barbora; Jan CIMBALNIK; Pavel DANIEL; Martin KOJAN; Robert ROMAN; Lenka JURKOVIČOVÁ; Martin PAIL; Milan BRÁZDIL; Michal KUCEWICZ a Petr KLIMES. Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery. Epilepsia. Hoboken: WILEY-BLACKWELL, 2026, 14 s. ISSN 0013-9580. Dostupné z: https://doi.org/10.1111/epi.18705.

@article{2544363,
   author = {Matoušková, Barbora and Cimbalnik, Jan and Daniel, Pavel and Kojan, Martin and Roman, Robert and Jurkovičová, Lenka and Pail, Martin and Brázdil, Milan and Kucewicz, Michal and Klimes, Petr},
   article_location = {Hoboken},
   doi = {https://doi.org/10.1111/epi.18705},
   keywords = {free recall task; functional connectivity; inferior frontal gyrus; intracranial EEG; middle temporal gyrus},
   language = {eng},
   issn = {0013-9580},
   journal = {Epilepsia},
   title = {Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery},
   url = {https://onlinelibrary-wiley-com.ezproxy.muni.cz/doi/10.1111/epi.18705},
   year = {2026}
}

TY  - JOUR
ID  - 2544363
AU  - Matoušková, Barbora - Cimbalnik, Jan - Daniel, Pavel - Kojan, Martin - Roman, Robert - Jurkovičová, Lenka - Pail, Martin - Brázdil, Milan - Kucewicz, Michal - Klimes, Petr
PY  - 2026
TI  - Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery
JF  - Epilepsia
PB  - WILEY-BLACKWELL
SN  - 00139580
KW  - free recall task
KW  - functional connectivity
KW  - inferior frontal gyrus
KW  - intracranial EEG
KW  - middle temporal gyrus
UR  - https://onlinelibrary-wiley-com.ezproxy.muni.cz/doi/10.1111/epi.18705
N2  - Objective Memory impairments are common in neurological disorders, especially drug-resistant epilepsy, where cognitive deficits such as accelerated long-term forgetting may occur before surgery due to interictal/ictal discharges, antiseizure medications, and disease progression. Postsurgical memory decline affects 40%-60% of patients. Understanding the neural mechanisms of memory encoding is essential for identifying critical network hubs and guiding surgical interventions that preserve cognitive function.Methods We analyzed intracranial electroencephalographic recordings from epilepsy patients (n = 15) performing a verbal memory encoding task to identify key structures involved in successful memory formation. Functional connectivity was computed using multiple features across several frequency bands. Temporal dynamics of connectivity were examined to characterize pre-encoding and encoding phases.Results The middle temporal gyrus (MTG) consistently emerged as a verbal memory hub across features and frequency bands. The inferior frontal gyrus (IFG) was identified as a beta-band-specific hub via phase synchrony. Temporal analyses revealed that MTG exhibited stable and widespread connectivity differences across all encoding phases, suggesting a role in pre-encoding network priming. In contrast, IFG displayed a transient decrease in connectivity and spatial extent during early encoding, indicating a more focal and dynamic contribution.Significance These findings suggest that successful memory encoding relies on widespread, frequency-specific connectivity patterns centered on MTG, complemented by transient, localized IFG activity. Identifying such hubs may inform surgical planning by highlighting regions critical for cognitive outcomes, ultimately supporting strategies to preserve memory in epilepsy surgery.
ER  -

MATOUŠKOVÁ, Barbora; Jan CIMBALNIK; Pavel DANIEL; Martin KOJAN; Robert ROMAN; Lenka JURKOVIČOVÁ; Martin PAIL; Milan BRÁZDIL; Michal KUCEWICZ a Petr KLIMES. Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery. \textit{Epilepsia}. Hoboken: WILEY-BLACKWELL, 2026, 14 s. ISSN~0013-9580. Dostupné z: https://doi.org/10.1111/epi.18705.

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