A whole population-based cohort study of the trajectory of the
prevalence and the incidence of mental illness, challenging
behaviour, and psychotropic medication prescribing in adults
with intellectual disabilities in the Czech Republic between
2010 and 2022

J 2025

A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022

DEB, Shoumitro; Jiří JARKOVSKÝ; Hana MELICHAROVÁ; David HOLUB; Bharati LIMBU et al.

Základní údaje

Originální název

A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022

Autoři

DEB, Shoumitro; Jiří JARKOVSKÝ ; Hana MELICHAROVÁ; David HOLUB; Bharati LIMBU a Petr TRESNAK

Vydání

BMC Psychiatry, London, Biomed Central, 2025, 1471-244X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Adults with intellectual disabilities; Mental illness; Challenging behaviour; Psychotropic medications; Neurodevelopmental disorders; Autism; ADHD; Prevalence; Incidence; Cohort study; Czech republic

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 1. 2026 08:48, Mgr. Tereza Miškechová

Anotace

V originále

Background It is essential to understand the complex interaction among mental illness, challenging behaviour and psychotropic medication prescribing among adults with intellectual disabilities to help reduce overmedication of psychotropics. Methods We analysed data from the Institute of Health Information and Statistics of the Czech Republic to estimate the prevalence of mental illness, challenging behaviour and psychotropic prescribing between 2010 and 2022 and incidence between 2015 and 2022. Results 62,636 (54% males) adults with intellectual disabilities contributed 704,503 person-years of data. In 2010, the prevalence of concomitant mental illness (ICD-10, F20-48) was 157%, challenging behaviour 29% and any psychotropic prescription 55%, increasing in 2022 to 173%, 305% and 59%, respectively. The prevalence of most individual mental illness categories either remained the same or marginally increased between 2010 and 2022, except anxiety disorders, the neurodevelopmental disorders like autism and attention-deficit hyperactivity disorder (ADHD), which showed a significant increase. The incidence of new diagnoses of mental illnesses and challenging behaviour decreased between 2015 and 2022, except for the neurodevelopmental disorders, which increased significantly. The incidence of challenging behaviour correlated significantly with psychoses, bipolar disorder, and anxiety disorder. The overall prevalence of most psychotropic prescribing correlated significantly with the prevalence of mental illnesses and challenging behaviour. Among those receiving antipsychotics, only 18% in 2010 and 19% in 2022 had severe mental illness (psychoses and/or bipolar disorder), which are the licensed indications for long-term antipsychotic prescriptions. In 2010, among those with challenging behaviour, 82% received psychotropics, 62% antipsychotics, 20% antidepressants, 17% anxiolytics, 30% mood stabilisers, and 04% hypnotics and sedatives. The incidence rates of new prescriptions among participants who displayed challenging behaviour fell for any psychotropics, antipsychotics, antidepressants and anxiolytics. However, the incidence of new prescriptions increased for mood stabilisers, and significantly for hypnotics/sedatives (Incidence Rate Ratio: 0.61; 95% Confidence Interval: 0.45-0.81; p < 0.001). Conclusions Challenging behaviour was significantly associated with some mental illnesses. Both mental illness and challenging behaviour were significantly associated with psychotropic medication prescribing. The prevalence of psychotropic medication prescribing overall and especially among those displaying challenging behaviour was high and showed a significant increase in antidepressants and hypnotics/sedatives prescriptions over 12 years.

Citovat

DEB, Shoumitro; Jiří JARKOVSKÝ; Hana MELICHAROVÁ; David HOLUB; Bharati LIMBU a Petr TRESNAK. A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022. BMC Psychiatry. London: Biomed Central, 2025, roč. 25, č. 1, s. 1-14. ISSN 1471-244X. Dostupné z: https://doi.org/10.1186/s12888-025-07620-7.

@article{2544620,
   author = {Deb, Shoumitro and Jarkovský, Jiří and Melicharová, Hana and Holub, David and Limbu, Bharati and Tresnak, Petr},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1186/s12888-025-07620-7},
   keywords = {Adults with intellectual disabilities; Mental illness; Challenging behaviour; Psychotropic medications; Neurodevelopmental disorders; Autism; ADHD; Prevalence; Incidence; Cohort study; Czech republic},
   language = {eng},
   issn = {1471-244X},
   journal = {BMC Psychiatry},
   title = {A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022},
   url = {https://link.springer.com/article/10.1186/s12888-025-07620-7},
   volume = {25},
   year = {2025}
}

TY  - JOUR
ID  - 2544620
AU  - Deb, Shoumitro - Jarkovský, Jiří - Melicharová, Hana - Holub, David - Limbu, Bharati - Tresnak, Petr
PY  - 2025
TI  - A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022
JF  - BMC Psychiatry
VL  - 25
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Biomed Central
SN  - 1471244X
KW  - Adults with intellectual disabilities
KW  - Mental illness
KW  - Challenging behaviour
KW  - Psychotropic medications
KW  - Neurodevelopmental disorders
KW  - Autism
KW  - ADHD
KW  - Prevalence
KW  - Incidence
KW  - Cohort study
KW  - Czech republic
UR  - https://link.springer.com/article/10.1186/s12888-025-07620-7
N2  - Background It is essential to understand the complex interaction among mental illness, challenging behaviour and psychotropic medication prescribing among adults with intellectual disabilities to help reduce overmedication of psychotropics. Methods We analysed data from the Institute of Health Information and Statistics of the Czech Republic to estimate the prevalence of mental illness, challenging behaviour and psychotropic prescribing between 2010 and 2022 and incidence between 2015 and 2022. Results 62,636 (54% males) adults with intellectual disabilities contributed 704,503 person-years of data. In 2010, the prevalence of concomitant mental illness (ICD-10, F20-48) was 157%, challenging behaviour 29% and any psychotropic prescription 55%, increasing in 2022 to 173%, 305% and 59%, respectively. The prevalence of most individual mental illness categories either remained the same or marginally increased between 2010 and 2022, except anxiety disorders, the neurodevelopmental disorders like autism and attention-deficit hyperactivity disorder (ADHD), which showed a significant increase. The incidence of new diagnoses of mental illnesses and challenging behaviour decreased between 2015 and 2022, except for the neurodevelopmental disorders, which increased significantly. The incidence of challenging behaviour correlated significantly with psychoses, bipolar disorder, and anxiety disorder. The overall prevalence of most psychotropic prescribing correlated significantly with the prevalence of mental illnesses and challenging behaviour. Among those receiving antipsychotics, only 18% in 2010 and 19% in 2022 had severe mental illness (psychoses and/or bipolar disorder), which are the licensed indications for long-term antipsychotic prescriptions. In 2010, among those with challenging behaviour, 82% received psychotropics, 62% antipsychotics, 20% antidepressants, 17% anxiolytics, 30% mood stabilisers, and 04% hypnotics and sedatives. The incidence rates of new prescriptions among participants who displayed challenging behaviour fell for any psychotropics, antipsychotics, antidepressants and anxiolytics. However, the incidence of new prescriptions increased for mood stabilisers, and significantly for hypnotics/sedatives (Incidence Rate Ratio: 0.61; 95% Confidence Interval: 0.45-0.81; p < 0.001). Conclusions Challenging behaviour was significantly associated with some mental illnesses. Both mental illness and challenging behaviour were significantly associated with psychotropic medication prescribing. The prevalence of psychotropic medication prescribing overall and especially among those displaying challenging behaviour was high and showed a significant increase in antidepressants and hypnotics/sedatives prescriptions over 12 years.
ER  -

DEB, Shoumitro; Jiří JARKOVSKÝ; Hana MELICHAROVÁ; David HOLUB; Bharati LIMBU a Petr TRESNAK. A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022. \textit{BMC Psychiatry}. London: Biomed Central, 2025, roč.~25, č.~1, s.~1-14. ISSN~1471-244X. Dostupné z: https://doi.org/10.1186/s12888-025-07620-7.

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