Alleviating UV-induced photoaging with oral hyaluronic acid:
insights from a hairless mouse model

J 2025

Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model

SIMEK, Matej; Romana SINOVA; Vratislav BERKA; Katerina LEHKA; Kristina NESPOROVA et al.

Základní údaje

Originální název

Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model

Autoři

SIMEK, Matej; Romana SINOVA; Vratislav BERKA; Katerina LEHKA; Kristina NESPOROVA; Iva DOLECKOVA; Martina BAJEROVÁ; Vojtech PAVLIK a Lukáš KUBALA

Vydání

International Journal of Biological Macromolecules, Amsterdam, Elsevier Science BV, 2025, 0141-8130

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.500 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00143262

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Photoaging; Hyaluronan; Metabolomics

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 1. 2026 13:06, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Hyaluronic acid (HA) is known for its beneficial effects on skin hydration and elasticity. However, the mechanisms by which HA dietary intake attenuates pathological processes in photoaged skin are still unclear. In this study, oral administration of HA, alone or in combination with hydrolysed collagen, was investigated to alleviate UV-induced inflammation, extracellular matrix (ECM) degradation, and metabolic alterations in the skin of SKH1 hairless mice repeatedly exposed to UVA and UVB radiation. Both supplements reduced UV-induced degradation of HA and collagen and decreased the inflammatory response in the skin. Interestingly, HA supplementation influenced cutaneous and plasma metabolism, elevating lipid catabolism and metabolic markers such as hydroxybutyrate and a-ketoglutarate. The addition of collagen did not provide any additional significant benefits over HA despite being administered at a 12-fold higher dose. These findings highlight superior role of HA as a nutritional supplement for skin health and provide insights into its potential mechanisms in addressing photoaged skin by modulating both skin and systemic metabolism.

Citovat

SIMEK, Matej; Romana SINOVA; Vratislav BERKA; Katerina LEHKA; Kristina NESPOROVA; Iva DOLECKOVA; Martina BAJEROVÁ; Vojtech PAVLIK a Lukáš KUBALA. Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model. International Journal of Biological Macromolecules. Amsterdam: Elsevier Science BV, 2025, roč. 321, Septembe, s. 1-11. ISSN 0141-8130. Dostupné z: https://doi.org/10.1016/j.ijbiomac.2025.146340.

@article{2546689,
   author = {Simek, Matej and Sinova, Romana and Berka, Vratislav and Lehka, Katerina and Nesporova, Kristina and Doleckova, Iva and Bajerová, Martina and Pavlik, Vojtech and Kubala, Lukáš},
   article_location = {Amsterdam},
   article_number = {Septembe},
   doi = {https://doi.org/10.1016/j.ijbiomac.2025.146340},
   keywords = {Photoaging; Hyaluronan; Metabolomics},
   language = {eng},
   issn = {0141-8130},
   journal = {International Journal of Biological Macromolecules},
   title = {Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model},
   url = {https://doi.org/10.1016/j.ijbiomac.2025.146340},
   volume = {321},
   year = {2025}
}

TY  - JOUR
ID  - 2546689
AU  - Simek, Matej - Sinova, Romana - Berka, Vratislav - Lehka, Katerina - Nesporova, Kristina - Doleckova, Iva - Bajerová, Martina - Pavlik, Vojtech - Kubala, Lukáš
PY  - 2025
TI  - Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model
JF  - International Journal of Biological Macromolecules
VL  - 321
IS  - Septembe
SP  - 1-11
EP  - 1-11
PB  - Elsevier Science BV
SN  - 01418130
KW  - Photoaging
KW  - Hyaluronan
KW  - Metabolomics
UR  - https://doi.org/10.1016/j.ijbiomac.2025.146340
N2  - Hyaluronic acid (HA) is known for its beneficial effects on skin hydration and elasticity. However, the mechanisms by which HA dietary intake attenuates pathological processes in photoaged skin are still unclear. In this study, oral administration of HA, alone or in combination with hydrolysed collagen, was investigated to alleviate UV-induced inflammation, extracellular matrix (ECM) degradation, and metabolic alterations in the skin of SKH1 hairless mice repeatedly exposed to UVA and UVB radiation. Both supplements reduced UV-induced degradation of HA and collagen and decreased the inflammatory response in the skin. Interestingly, HA supplementation influenced cutaneous and plasma metabolism, elevating lipid catabolism and metabolic markers such as hydroxybutyrate and a-ketoglutarate. The addition of collagen did not provide any additional significant benefits over HA despite being administered at a 12-fold higher dose. These findings highlight superior role of HA as a nutritional supplement for skin health and provide insights into its potential mechanisms in addressing photoaged skin by modulating both skin and systemic metabolism.
ER  -

SIMEK, Matej; Romana SINOVA; Vratislav BERKA; Katerina LEHKA; Kristina NESPOROVA; Iva DOLECKOVA; Martina BAJEROVÁ; Vojtech PAVLIK a Lukáš KUBALA. Alleviating UV-induced photoaging with oral hyaluronic acid: insights from a hairless mouse model. \textit{International Journal of Biological Macromolecules}. Amsterdam: Elsevier Science BV, 2025, roč.~321, Septembe, s.~1-11. ISSN~0141-8130. Dostupné z: https://doi.org/10.1016/j.ijbiomac.2025.146340.

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