Radiofrequency and targeted ultrasound enhance natural
hyaluronic production: a pilot porcine study

J 2025

Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study

BERNARDY, Jan; Klaus FRITZ; Carmen SALAVASTRU; Rea JAROSOVA; Natálie KRÁLOVÁ et al.

Základní údaje

Originální název

Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study

Autoři

BERNARDY, Jan; Klaus FRITZ; Carmen SALAVASTRU; Rea JAROSOVA a Natálie KRÁLOVÁ

Vydání

JOURNAL OF ULTRASOUND, CHAM, SPRINGER INT PUBL AG, 2025, 1971-3495

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.400 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00143294

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Hyaluronic acid; Radiofrequency; Targeted ultrasound; Facial rejuvenation; Fibroblast stimulation

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 1. 2026 17:23, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Background Loss of skin elasticity and youthful appearance is closely linked to reduced hyaluronic acid (HA) levels in the dermis. While topical HA products offer temporary effects, they do not address the root cause of HA depletion. Objective The present study aims to describe how to induce HA synthesis through fibroblast stimulation. Materials and Methods Twelve sows were divided into two groups. One group (n = 9) received four consecutive Radiofrequency (RF) and Targeted Ultrasound (TUS) treatments, the other group (n = 3) received four RF treatments only. Samples were collected via punch biopsy from the treated area of each animal at the baseline, 1-month, and 2-month follow-up. Samples were then processed and prepared for enzyme-linked immunosorbent assay as well as hyaluronic acid binding protein with diaminobenzidine (HABP-DAP) staining, which allows for visualization of HA within tissue. Findings The group receiving RF + TUS treatment has demonstrated an increase from an average of 83.0 µg/g at the baseline to 163.0 µg/g at the 2-month follow-up of HA concentration in the skin. Histology samples clearly demonstrate higher tissue density with an increase of brown pigment due to the HABP-DAP stain, representing HA in the skin. In comparison, the RF standalone treatment group has shown no significant increase in HA concentrations. Conclusion Study results show no significant increase in HA production following the RF stand alone treatment. Whereas the RF + TUS treatment group induced a significant HA production response as well as histophysiological changes in the dermis.

Citovat

BERNARDY, Jan; Klaus FRITZ; Carmen SALAVASTRU; Rea JAROSOVA a Natálie KRÁLOVÁ. Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study. JOURNAL OF ULTRASOUND. CHAM: SPRINGER INT PUBL AG, 2025, roč. 28, č. 4, s. 1001-1006. ISSN 1971-3495. Dostupné z: https://doi.org/10.1007/s40477-025-01083-y.

@article{2547137,
   author = {Bernardy, Jan and Fritz, Klaus and Salavastru, Carmen and Jarosova, Rea and Králová, Natálie},
   article_location = {CHAM},
   article_number = {4},
   doi = {https://doi.org/10.1007/s40477-025-01083-y},
   keywords = {Hyaluronic acid; Radiofrequency; Targeted ultrasound; Facial rejuvenation; Fibroblast stimulation},
   language = {eng},
   issn = {1971-3495},
   journal = {JOURNAL OF ULTRASOUND},
   title = {Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study},
   url = {https://link.springer.com/article/10.1007/s40477-025-01083-y},
   volume = {28},
   year = {2025}
}

TY  - JOUR
ID  - 2547137
AU  - Bernardy, Jan - Fritz, Klaus - Salavastru, Carmen - Jarosova, Rea - Králová, Natálie
PY  - 2025
TI  - Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study
JF  - JOURNAL OF ULTRASOUND
VL  - 28
IS  - 4
SP  - 1001-1006
EP  - 1001-1006
PB  - SPRINGER INT PUBL AG
SN  - 19713495
KW  - Hyaluronic acid
KW  - Radiofrequency
KW  - Targeted ultrasound
KW  - Facial rejuvenation
KW  - Fibroblast stimulation
UR  - https://link.springer.com/article/10.1007/s40477-025-01083-y
N2  - Background Loss of skin elasticity and youthful appearance is closely linked to reduced hyaluronic acid (HA) levels in the dermis. While topical HA products offer temporary effects, they do not address the root cause of HA depletion. Objective The present study aims to describe how to induce HA synthesis through fibroblast stimulation. Materials and Methods Twelve sows were divided into two groups. One group (n = 9) received four consecutive Radiofrequency (RF) and Targeted Ultrasound (TUS) treatments, the other group (n = 3) received four RF treatments only. Samples were collected via punch biopsy from the treated area of each animal at the baseline, 1-month, and 2-month follow-up. Samples were then processed and prepared for enzyme-linked immunosorbent assay as well as hyaluronic acid binding protein with diaminobenzidine (HABP-DAP) staining, which allows for visualization of HA within tissue. Findings The group receiving RF + TUS treatment has demonstrated an increase from an average of 83.0 µg/g at the baseline to 163.0 µg/g at the 2-month follow-up of HA concentration in the skin. Histology samples clearly demonstrate higher tissue density with an increase of brown pigment due to the HABP-DAP stain, representing HA in the skin. In comparison, the RF standalone treatment group has shown no significant increase in HA concentrations. Conclusion Study results show no significant increase in HA production following the RF stand alone treatment. Whereas the RF + TUS treatment group induced a significant HA production response as well as histophysiological changes in the dermis.
ER  -

BERNARDY, Jan; Klaus FRITZ; Carmen SALAVASTRU; Rea JAROSOVA a Natálie KRÁLOVÁ. Radiofrequency and targeted ultrasound enhance natural hyaluronic production: a pilot porcine study. \textit{JOURNAL OF ULTRASOUND}. CHAM: SPRINGER INT PUBL AG, 2025, roč.~28, č.~4, s.~1001-1006. ISSN~1971-3495. Dostupné z: https://doi.org/10.1007/s40477-025-01083-y.

Přehled o publikaci