Assisted Reproduction Therapy in Patients with Multiple
Sclerosis: Narrative Review and Practical Recommendations

J 2025

Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations

MEKIŇOVÁ, Lenka; Iva ŠROTOVÁ; Petra HANÁKOVÁ; Pavlína DANHOFER; Robert HUDEČEK et al.

Základní údaje

Originální název

Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations

Autoři

MEKIŇOVÁ, Lenka; Iva ŠROTOVÁ; Petra HANÁKOVÁ; Pavlína DANHOFER; Robert HUDEČEK a Michal JEŠETA

Vydání

Healthcare, BASEL, MDPI, 2025, 2227-9032

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143387

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

IVF; multiple sclerosis; autoimmune disease; ovarian stimulation; antagonist protocol; agonist protocol

Štítky

14110221, 14110240, 14110320, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2026 10:35, Mgr. Tereza Miškechová

Anotace

V originále

Objective: The objective of this study is to present contemporary findings regarding the relationship between the application of assisted reproduction methods and their impact on the incidence of multiple sclerosis. Design: This study adopts a narrative review design. Text: Assisted reproductive technology (ART) is increasingly used to treat human infertility. Due to the massive use of these techniques, it is increasingly important to record not only the course of fertilization and embryonic and fetal development of the individual but also the overall health status of the children born and their mothers. The incidence of autoimmune diseases continues to rise for reasons that remain unclear. One of the factors considered in connection with autoimmune disorders is ART. Opinions on the safety and reliability of ART methods are not consistent. Recently, extensive studies focusing on this issue have been presented and have not found a connection between infertility treatment with assisted reproductive techniques and the development of multiple sclerosis (MS). Conclusions: Current evidence suggests that, in adherence to the principles of evidence-based medicine and modern approaches to multiple sclerosis therapy, assisted reproduction in women with this disease is effective and does not pose a serious health risk. Therefore, it is necessary to always individualize therapy with regard to future pregnancy. Interdisciplinary cooperation on the timing of IVF therapy and minimizing the risk of MS exacerbation is also important.

Návaznosti

MUNI/A/1522/2024, interní kód MU

Název: Diagnostika komplikací a komorbidit neurologických onemocnění

Investor: Masarykova univerzita, Diagnostika komplikací a komorbidit neurologických onemocnění

Citovat

MEKIŇOVÁ, Lenka; Iva ŠROTOVÁ; Petra HANÁKOVÁ; Pavlína DANHOFER; Robert HUDEČEK a Michal JEŠETA. Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations. Healthcare. BASEL: MDPI, 2025, roč. 13, č. 23, s. 1-16. ISSN 2227-9032. Dostupné z: https://doi.org/10.3390/healthcare13233155.

@article{2547626,
   author = {Mekiňová, Lenka and Šrotová, Iva and Hanáková, Petra and Danhofer, Pavlína and Hudeček, Robert and Ješeta, Michal},
   article_location = {BASEL},
   article_number = {23},
   doi = {https://doi.org/10.3390/healthcare13233155},
   keywords = {IVF; multiple sclerosis; autoimmune disease; ovarian stimulation; antagonist protocol; agonist protocol},
   language = {eng},
   issn = {2227-9032},
   journal = {Healthcare},
   title = {Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations},
   url = {https://www.mdpi.com/2227-9032/13/23/3155},
   volume = {13},
   year = {2025}
}

TY  - JOUR
ID  - 2547626
AU  - Mekiňová, Lenka - Šrotová, Iva - Hanáková, Petra - Danhofer, Pavlína - Hudeček, Robert - Ješeta, Michal
PY  - 2025
TI  - Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations
JF  - Healthcare
VL  - 13
IS  - 23
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 22279032
KW  - IVF
KW  - multiple sclerosis
KW  - autoimmune disease
KW  - ovarian stimulation
KW  - antagonist protocol
KW  - agonist protocol
UR  - https://www.mdpi.com/2227-9032/13/23/3155
N2  - Objective: The objective of this study is to present contemporary findings regarding the relationship between the application of assisted reproduction methods and their impact on the incidence of multiple sclerosis. Design: This study adopts a narrative review design. Text: Assisted reproductive technology (ART) is increasingly used to treat human infertility. Due to the massive use of these techniques, it is increasingly important to record not only the course of fertilization and embryonic and fetal development of the individual but also the overall health status of the children born and their mothers. The incidence of autoimmune diseases continues to rise for reasons that remain unclear. One of the factors considered in connection with autoimmune disorders is ART. Opinions on the safety and reliability of ART methods are not consistent. Recently, extensive studies focusing on this issue have been presented and have not found a connection between infertility treatment with assisted reproductive techniques and the development of multiple sclerosis (MS). Conclusions: Current evidence suggests that, in adherence to the principles of evidence-based medicine and modern approaches to multiple sclerosis therapy, assisted reproduction in women with this disease is effective and does not pose a serious health risk. Therefore, it is necessary to always individualize therapy with regard to future pregnancy. Interdisciplinary cooperation on the timing of IVF therapy and minimizing the risk of MS exacerbation is also important.
ER  -

MEKIŇOVÁ, Lenka; Iva ŠROTOVÁ; Petra HANÁKOVÁ; Pavlína DANHOFER; Robert HUDEČEK a Michal JEŠETA. Assisted Reproduction Therapy in Patients with Multiple Sclerosis: Narrative Review and Practical Recommendations. \textit{Healthcare}. BASEL: MDPI, 2025, roč.~13, č.~23, s.~1-16. ISSN~2227-9032. Dostupné z: https://doi.org/10.3390/healthcare13233155.

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