Lumbar paraspinal muscles in patients with chronic non-specific
low back pain and the effect of exercise: comparative and
interventional study

J 2025

Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study

KOKOŠOVÁ, Viktória; Daniela VLAŽNÁ; Peter KRKOŠKA; Michaela SLÁDEČKOVÁ; Marek DOSTÁL et al.

Základní údaje

Originální název

Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study

Autoři

KOKOŠOVÁ, Viktória; Daniela VLAŽNÁ; Peter KRKOŠKA; Michaela SLÁDEČKOVÁ; Marek DOSTÁL; Kateřina MATULOVÁ; Radim GERSTBERGER; Petra OVESNÁ a Blanka ADAMOVÁ

Vydání

FRONTIERS IN REHABILITATION SCIENCES, LAUSANNE, FRONTIERS MEDIA SA, 2025, 2673-6861

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

magnetic resonance imaging; paraspinal muscles; muscle strength; endurance; low back pain; exercise therapy

Štítky

14110221, 14110234, 14110511, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2026 10:00, Mgr. Tereza Miškechová

Anotace

V originále

Background Lumbar paraspinal muscles (LPM), which belong to lumbar extensor muscles, play a key role in stabilising the lumbar spine and maintaining spine health. Although chronic non-specific low back pain (CNLBP) represents a major health problem worldwide, there is a knowledge gap regarding the function, morphology of LPM, and the effect of regular exercise on them in patients with CNLBP. The purpose of the study was to evaluate functional and quantitative MRI (qMRI) parameters of LPM in CNLBP patients, compare them to matched healthy volunteers (HV), and assess the effect of exercise therapy on these parameters in CNLBP patients. Methods The first part of the study was cross-sectional, observational, and comparative; the second was prospective and interventional. Based on physiological parameters, 43 matched pairs of CNLBP patients and HV were formed. All participants underwent MRI of the LPM using a 6-point Dixon gradient-echo sequence to assess qMRI parameters: fat fraction, total muscle volume, and functional muscle volume (FMV). Maximal isometric lumbar extensor muscle strength (MILEMS), lumbar extensor muscle endurance (LEME), MILEMS to LPM FMV ratio, pain, and disability were assessed. Each group's parameters were compared and effect size evaluated. The total of 29 patients entered an 18-week hybrid guided daily home-based exercise programme, which was completed by 27 CNLBP patients. The study was registered, trial registration number is ISRCTN11556477. Results CNLBP patients had significantly lower MILEMS, LEME (both P < 0.001), and MILEMS to LPM FMV ratio (P = 0.006) compared to matched HV. These parameters, as well as pain and disability, improved significantly after exercise (each P < 0.001). The qMRI parameters did not differ between CNLBP patients and HV, nor did they change after exercise therapy. Conclusions The significant LPM dysfunction and poorer muscle quality in CNLBP patients were reversible with exercise. Our study does not support the use of qMRI parameters as objective and reliable biomarkers of LPM dysfunction in a cohort of CNLBP with mild clinical impairment.

Návaznosti

MUNI/A/1522/2024, interní kód MU

Název: Diagnostika komplikací a komorbidit neurologických onemocnění

Investor: Masarykova univerzita, Diagnostika komplikací a komorbidit neurologických onemocnění

Citovat

KOKOŠOVÁ, Viktória; Daniela VLAŽNÁ; Peter KRKOŠKA; Michaela SLÁDEČKOVÁ; Marek DOSTÁL; Kateřina MATULOVÁ; Radim GERSTBERGER; Petra OVESNÁ a Blanka ADAMOVÁ. Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study. FRONTIERS IN REHABILITATION SCIENCES. LAUSANNE: FRONTIERS MEDIA SA, 2025, roč. 6, December 2025, s. 1-14. ISSN 2673-6861. Dostupné z: https://doi.org/10.3389/fresc.2025.1714052.

@article{2548313,
   author = {Kokošová, Viktória and Vlažná, Daniela and Krkoška, Peter and Sládečková, Michaela and Dostál, Marek and Matulová, Kateřina and Gerstberger, Radim and Ovesná, Petra and Adamová, Blanka},
   article_location = {LAUSANNE},
   article_number = {December 2025},
   doi = {https://doi.org/10.3389/fresc.2025.1714052},
   keywords = {magnetic resonance imaging; paraspinal muscles; muscle strength; endurance; low back pain; exercise therapy},
   language = {eng},
   issn = {2673-6861},
   journal = {FRONTIERS IN REHABILITATION SCIENCES},
   title = {Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study},
   url = {https://www.frontiersin.org/journals/rehabilitation-sciences/articles/10.3389/fresc.2025.1714052/full},
   volume = {6},
   year = {2025}
}

TY  - JOUR
ID  - 2548313
AU  - Kokošová, Viktória - Vlažná, Daniela - Krkoška, Peter - Sládečková, Michaela - Dostál, Marek - Matulová, Kateřina - Gerstberger, Radim - Ovesná, Petra - Adamová, Blanka
PY  - 2025
TI  - Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study
JF  - FRONTIERS IN REHABILITATION SCIENCES
VL  - 6
IS  - December 2025
SP  - 1-14
EP  - 1-14
PB  - FRONTIERS MEDIA SA
SN  - 26736861
KW  - magnetic resonance imaging
KW  - paraspinal muscles
KW  - muscle strength
KW  - endurance
KW  - low back pain
KW  - exercise therapy
UR  - https://www.frontiersin.org/journals/rehabilitation-sciences/articles/10.3389/fresc.2025.1714052/full
N2  - Background Lumbar paraspinal muscles (LPM), which belong to lumbar extensor muscles, play a key role in stabilising the lumbar spine and maintaining spine health. Although chronic non-specific low back pain (CNLBP) represents a major health problem worldwide, there is a knowledge gap regarding the function, morphology of LPM, and the effect of regular exercise on them in patients with CNLBP. The purpose of the study was to evaluate functional and quantitative MRI (qMRI) parameters of LPM in CNLBP patients, compare them to matched healthy volunteers (HV), and assess the effect of exercise therapy on these parameters in CNLBP patients. Methods The first part of the study was cross-sectional, observational, and comparative; the second was prospective and interventional. Based on physiological parameters, 43 matched pairs of CNLBP patients and HV were formed. All participants underwent MRI of the LPM using a 6-point Dixon gradient-echo sequence to assess qMRI parameters: fat fraction, total muscle volume, and functional muscle volume (FMV). Maximal isometric lumbar extensor muscle strength (MILEMS), lumbar extensor muscle endurance (LEME), MILEMS to LPM FMV ratio, pain, and disability were assessed. Each group's parameters were compared and effect size evaluated. The total of 29 patients entered an 18-week hybrid guided daily home-based exercise programme, which was completed by 27 CNLBP patients. The study was registered, trial registration number is ISRCTN11556477. Results CNLBP patients had significantly lower MILEMS, LEME (both P < 0.001), and MILEMS to LPM FMV ratio (P = 0.006) compared to matched HV. These parameters, as well as pain and disability, improved significantly after exercise (each P < 0.001). The qMRI parameters did not differ between CNLBP patients and HV, nor did they change after exercise therapy. Conclusions The significant LPM dysfunction and poorer muscle quality in CNLBP patients were reversible with exercise. Our study does not support the use of qMRI parameters as objective and reliable biomarkers of LPM dysfunction in a cohort of CNLBP with mild clinical impairment.
ER  -

KOKOŠOVÁ, Viktória; Daniela VLAŽNÁ; Peter KRKOŠKA; Michaela SLÁDEČKOVÁ; Marek DOSTÁL; Kateřina MATULOVÁ; Radim GERSTBERGER; Petra OVESNÁ a Blanka ADAMOVÁ. Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study. \textit{FRONTIERS IN REHABILITATION SCIENCES}. LAUSANNE: FRONTIERS MEDIA SA, 2025, roč.~6, December 2025, s.~1-14. ISSN~2673-6861. Dostupné z: https://doi.org/10.3389/fresc.2025.1714052.

Přehled o publikaci