Determinants of tuberculosis infection and disease in
paediatric patients in the Czech Republic after tuberculosis
exposure

J 2025

Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure

BACA, Lubos; Martin MAGNER a Karolina DOLEZALOVA

Základní údaje

Originální název

Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure

Autoři

BACA, Lubos; Martin MAGNER a Karolina DOLEZALOVA

Vydání

INTERNATIONAL HEALTH, ENGLAND, OXFORD UNIV PRESS, 2025, 1876-3413

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.200 v roce 2024

Organizační jednotka

CZECRIN IV

DOI

https://doi.org/10.1093/inthealth/ihaf151

UT WoS

001643971300001

Klíčová slova česky

child; computed tomography; contact tracing; tuberculosis; tuberculosis infection; Ukrainian refugee

Klíčová slova anglicky

child; computed tomography; contact tracing; tuberculosis; tuberculosis infection; Ukrainian refugee

Štítky

CZECRIN, Excelence Science, RIV, user

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2026 10:58, Bc. Hana Vladíková, BBA

Anotace

V originále

Background Mycobacterium tuberculosis is a transmissible pathogen most commonly acquired through contact with an infectious individual. Early initiation of tuberculosis (TB) preventive treatment (TPT) in high-risk populations can substantially reduce the risk of TB infection (TBI) and/or progression to active disease. Our objectives were to identify risk factors for children and adolescents developing TBI and TB after exposure and to evaluate the diagnostic utility of chest computed tomography (CT).Methods A 6.5-year retrospective cohort study was conducted at a single centre in the Czech Republic to assess risk factors for TBI and TB in children and adolescents (0-18 y).Results Of 335 children included in the study (median age 6.85 y), TBI was diagnosed in 83 (25%) and TB in 39 (12%). Chest CT in 45 high-risk contacts identified TB in an additional 13 participants. The key TB risk factor was index patients having smear-positive TB (odds ratio [OR] 11.35), while older age of contacts (OR 0.83) and non-household exposure (OR 0.23) had a lower risk of TB. TBI risk increased with age (OR 1.21), index smear-positive patients (OR 4.66) and when the father was the index patient (OR 2.91). Ukrainian refugee children had higher risks of TB (relative risk 3.4). Adherence to TPT in those who qualified was good.Conclusions Risk factors for TBI and TB were identified, including children being from Ukraine. Chest CT may aid in early diagnosis of TB.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

BACA, Lubos; Martin MAGNER a Karolina DOLEZALOVA. Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure. INTERNATIONAL HEALTH. ENGLAND: OXFORD UNIV PRESS, 2025, na, na, s. 1-6. ISSN 1876-3413. Dostupné z: https://doi.org/10.1093/inthealth/ihaf151.

@article{2548330,
   author = {Baca, Lubos and Magner, Martin and Dolezalova, Karolina},
   article_location = {ENGLAND},
   article_number = {na},
   doi = {https://doi.org/10.1093/inthealth/ihaf151},
   keywords = {child; computed tomography; contact tracing; tuberculosis; tuberculosis infection; Ukrainian refugee},
   language = {eng},
   issn = {1876-3413},
   journal = {INTERNATIONAL HEALTH},
   title = {Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure},
   url = {https://watermark02.silverchair.com/ihaf151.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA48wggOLBgkqhkiG9w0BBwagggN8MIIDeAIBADCCA3EGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMxOKykvOzRURjO4xtAgEQgIIDQp2kIwnnqV2-cclrSzHZr-UYE7fcWqky5eagXWwBjsQd},
   volume = {na},
   year = {2025}
}

TY  - JOUR
ID  - 2548330
AU  - Baca, Lubos - Magner, Martin - Dolezalova, Karolina
PY  - 2025
TI  - Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure
JF  - INTERNATIONAL HEALTH
VL  - na
IS  - na
SP  - 1-6
EP  - 1-6
PB  - OXFORD UNIV PRESS
SN  - 18763413
KW  - child
KW  - computed tomography
KW  - contact tracing
KW  - tuberculosis
KW  - tuberculosis infection
KW  - Ukrainian refugee
UR  - https://watermark02.silverchair.com/ihaf151.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA48wggOLBgkqhkiG9w0BBwagggN8MIIDeAIBADCCA3EGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMxOKykvOzRURjO4xtAgEQgIIDQp2kIwnnqV2-cclrSzHZr-UYE7fcWqky5eagXWwBjsQd
N2  - Background Mycobacterium tuberculosis is a transmissible pathogen most commonly acquired through contact with an infectious individual. Early initiation of tuberculosis (TB) preventive treatment (TPT) in high-risk populations can substantially reduce the risk of TB infection (TBI) and/or progression to active disease. Our objectives were to identify risk factors for children and adolescents developing TBI and TB after exposure and to evaluate the diagnostic utility of chest computed tomography (CT).Methods A 6.5-year retrospective cohort study was conducted at a single centre in the Czech Republic to assess risk factors for TBI and TB in children and adolescents (0-18 y).Results Of 335 children included in the study (median age 6.85 y), TBI was diagnosed in 83 (25%) and TB in 39 (12%). Chest CT in 45 high-risk contacts identified TB in an additional 13 participants. The key TB risk factor was index patients having smear-positive TB (odds ratio [OR] 11.35), while older age of contacts (OR 0.83) and non-household exposure (OR 0.23) had a lower risk of TB. TBI risk increased with age (OR 1.21), index smear-positive patients (OR 4.66) and when the father was the index patient (OR 2.91). Ukrainian refugee children had higher risks of TB (relative risk 3.4). Adherence to TPT in those who qualified was good.Conclusions Risk factors for TBI and TB were identified, including children being from Ukraine. Chest CT may aid in early diagnosis of TB.
ER  -

BACA, Lubos; Martin MAGNER a Karolina DOLEZALOVA. Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure. \textit{INTERNATIONAL HEALTH}. ENGLAND: OXFORD UNIV PRESS, 2025, na, na, s.~1-6. ISSN~1876-3413. Dostupné z: https://doi.org/10.1093/inthealth/ihaf151.

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